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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Felbamate
    CAS No.: 25451-15-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Felbatol; 2-phenylpropane-1... Quality Control & MSDS Files:
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    Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.

  • Chemical Name: Ellagic acid
    CAS No.: 476-66-4 Purity: Appearances: Light yellow to khaki Solid
    Brand: Synonyms: 2,3,7,8-tetrahydroxy(1)benz... Quality Control & MSDS Files:
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    Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.

  • Chemical Name: Imiquimod
    CAS No.: 99011-02-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Aldara;R 837;Zyclara; 1-iso... Quality Control & MSDS Files:
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    Immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.

  • Chemical Name: Guanidine Hydrochloride
    CAS No.: 50-01-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: guanidine hydrochloride Quality Control & MSDS Files:
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    Protein denaturant.

  • Chemical Name: Escitalopram oxalate
    CAS No.: 219861-08-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (S)-(+)Citalopram oxalate;C... Quality Control & MSDS Files:
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    Selective 5-HT reuptake inhibitor (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Is a S-enantiomer and eutomer of citalopram (Cat. No. 1427).

  • Chemical Name: Sertraline hydrochloride
    CAS No.: 79559-97-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Zoloft;Lustral; (1S,4S)-4-(... Quality Control & MSDS Files:
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    Potent, orally active selective serotonin re-uptake inhibitor (SSRI); antidepressant.

  • Chemical Name: Abacavir hemisulfate
    CAS No.: 188062-50-2 Purity: Appearances:
    Brand: Synonyms: (1S,4R)-4-[2-Amino-6-(cyclo... Quality Control & MSDS Files:
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    Competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.

  • Chemical Name: CCG 1423
    CAS No.: 285986-88-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: CCG1423, CCG 1423 Quality Control & MSDS Files:
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    Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it ...

  • Chemical Name: Milnacipran hydrochloride
    CAS No.: 101152-94-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Dalcipran hydrochloride;Ixe... Quality Control & MSDS Files:
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    Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

  • Chemical Name: L-Ascorbic acid
    CAS No.: 50-81-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: L-Ascorbic acid; Vitamin C;... Quality Control & MSDS Files:
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    Inhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Naturally occurring antioxidant.

  • Chemical Name: Pravastatin sodium salt
    CAS No.: 81131-70-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Pravachol sodium; sodium (3... Quality Control & MSDS Files:
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    Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.

  • Chemical Name: (S)-Duloxetine hydrochloride
    CAS No.: 136434-34-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: N-Methyl-gama-(1-naphthalen... Quality Control & MSDS Files:
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    High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K<sub>i</sub> values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC<sub>50</sub> values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K<sub>i</sub> = 3...

  • Chemical Name: CP 31398 dihydrochloride
    CAS No.: 1217195-61-3 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: CP31398 dihydrochloride;CP-... Quality Control & MSDS Files:
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    p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts <em>in vivo</em>. </div> <div class='pDbd2'> <h3>Licensing Information</h3> Sold for research purposes under agreement from Pfiz...

  • Chemical Name: SB 203580 hydrochloride
    CAS No.: 869185-85-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: RWJ 64809 hydrochloride;SB2... Quality Control & MSDS Files:
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    Water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and ...

  • Chemical Name: Ketotifen fumarate
    CAS No.: 34580-14-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: HC 20511 fumarate; 4-(1-met... Quality Control & MSDS Files:
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    An H1 receptor antagonist.

  • Chemical Name: Fluticasone propionate
    CAS No.: 80474-14-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (6S,8S,9R,10S,11S,13S,14S,1... Quality Control & MSDS Files:
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    High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory ...

  • Chemical Name: Ticlopidine hydrochloride
    CAS No.: 53885-35-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 5-(2-chlorobenzyl)-4,5,6,7-... Quality Control & MSDS Files:
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    Selective P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.

  • Chemical Name: Fluvastatin sodium
    CAS No.: 93957-55-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Leschol sodium; sodium (3R,... Quality Control & MSDS Files:
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    Orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

  • Chemical Name: Nicotinamide
    CAS No.: 98-92-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 3-Pyridinecarboxamide; Niac... Quality Control & MSDS Files:
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    Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.

  • Chemical Name: Verteporfin
    CAS No.: 129497-78-5 Purity: Appearances: light brown to black Solid
    Brand: Synonyms: trans-3,4-Dicarboxy-4,4a-di... Quality Control & MSDS Files:
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    YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

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