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Tocris Bioscience Inc.

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Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Fluvoxamine maleate
    CAS No.: 61718-82-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (E)-5-Methoxy-1-[4-(trifluo... Quality Control & MSDS Files:
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    Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a K<sub>i</sub> of 1.6 nmol/l. Also available as part of the <a href='dispprod.php?ItemId=83096'>Serotonin Uptake Inhibitor Tocriset&#8482;</a>.

  • Chemical Name: Fluoxetine hydrochloride
    CAS No.: 56296-78-7 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: LY110140;LY 110140;LY-11014... Quality Control & MSDS Files:
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    Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K<sub>i</sub> of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub>, H<sub>1</sub>, <span class='symbol'>&alpha;</span><sub>1</sub>, <span class='symbol'>&alpha;</span><sub>2</sub>-adrenergic, and muscari...

  • Chemical Name: Fluconazole
    CAS No.: 86386-73-4 Purity: Appearances: White to off-white Solid
    Brand:Tocris Synonyms: UK 49858;UK49858;UK-49858; ... Quality Control & MSDS Files:
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    Triazole antifungal agent. Effective against <em>Candida</em> strains <em>in vitro</em> and <em>in vivo</em>. </div> <div class='pDbd2'> <h3>Licensing Information</h3> Sold for research purposes under agreement from Pfizer Inc. </div> <div class='pDbd1b'> <div class='pDbdA'> <h3>Technical Data</h3> <...

  • Chemical Name: Etomidate
    CAS No.: 33125-97-2 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Amidate;R16659;R 16659;R-16... Quality Control & MSDS Files:
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    General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with <span class='symbol'>&beta;</span>2- and <span class='symbol'>&beta;</span>3-subunit containing GABA<sub>A</sub> receptors. Short acting and potent hypnotic, with low toxicity.

  • Chemical Name: Edaravone
    CAS No.: 89-25-8 Purity: #99 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: 3-Methyl-1-phenyl-2-pyrazol... Quality Control & MSDS Files:
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    A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

  • Chemical Name: Doxazosin mesylate
    CAS No.: 77883-43-3 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: UK 33274 mesylate; (4-(4-am... Quality Control & MSDS Files:
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    Selective <span class='symbol'>&alpha;</span><sub>1</sub>-adrenoceptor antagonist (pK<sub>i</sub> values are 9.0, 8.5 and 8.4 for human <span class='symbol'>&alpha;</span><sub>1B</sub>, <span class='symbol'>&alpha;</span><sub>1A</sub> and <span class='symbol'>&alpha;</span><sub>1D</sub> receptors respectively). Displays antihyperte...

  • Chemical Name: Floxuridine
    CAS No.: 50-91-9 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Fluorodeoxyuridine; Fluorur... Quality Control & MSDS Files:
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    Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

  • Chemical Name: C16
    CAS No.: 608512-97-6 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: (E)-8-((1H-imidazol-5-yl)me... Quality Control & MSDS Files:
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    PKR inhibitor (IC<sub>50</sub> = 210 nM). Rescues PKR-dependent translation block <em>in vitro</em>. Decreases A<span class='symbol'>&#946;</span>42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

  • Chemical Name: UNC0642
    CAS No.: 1481677-78-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Quality Control & MSDS Files:
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    UNC0642 is a potent and selective <b>G9a/GLP</b> inhibitor, inhibits G9a/GLP with an <b>IC<sub>50</sub></b> of less than 2.5 nM.

  • Chemical Name: A 582941
    CAS No.: 848591-90-2 Purity: #98 % Appearances:
    Brand:Tocris Synonyms: 2-methyl-5-(6-phenylpyridaz... Quality Control & MSDS Files:
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    Selective <span class='symbol'>&#945;</span>7 nAChR partial agonist; exhibits high affinity for both rat and human <span class='symbol'>&#945;</span>7 receptors (K<sub>i</sub> values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for <span class='symbol'>&#945;</span>7 over 5-HT<sub>3</sub> receptors (K<sub>i</su...

  • Chemical Name: Cetirizine (dihydrochloride)
    CAS No.: 83881-52-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-(2-{4-[(4-Chlorophenyl)(p... Quality Control & MSDS Files:
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    Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

  • Chemical Name: Artemisinin
    CAS No.: 63968-64-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (+)-Arteannuin; Qinghaosu; ... Quality Control & MSDS Files:
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    Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of <em>Plasmodium falciparum</em> (K<sub>i</sub> ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-...

  • Chemical Name: Adapalene
    CAS No.: 106685-40-9 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: CD 271;CD271;CD-271;Differi... Quality Control & MSDS Files:
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    Retinoic acid analog that is a RAR<span class='symbol'>&beta;</span> and RAR<span class='symbol'>&gamma;</span> agonist (AC<sub>50</sub> values are 2.2, 9.3, 22 and &gt; 1000 nM for RAR<span class='symbol'>&beta;</span>, RAR<span class='symbol'>&gamma;</span>, RAR<span class='symbol'>&alpha;</span> and RXR<span class='symbol'>&alph...

  • Chemical Name: Leflunomide
    CAS No.: 75706-12-6 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: HWA486;RS-34821;SU101; 5-me... Quality Control & MSDS Files:
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    Inhibitor of dihydroorotate dehydrogenase (IC<sub>50</sub> = 2.5 <span class='symbol'>&#956;</span>M). Inhibits <em>de novo</em> pyrimidine synthesis in human T cells <em>in vitro</em>; also inhibits lymphocyte proliferation. Exhibits efficacy in several animal models of autoimmune disease, arthritis and graft rejection. Active met...

  • Chemical Name: Cilostazol
    CAS No.: 73963-72-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: OPC 13013;OPC 21;Pletaal; 6... Quality Control & MSDS Files:
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    Cilostazol(OPC 13013; OPC 21) is a potent inhibitor of PDE3A, the isoform of PDE 3 in the cardiovascular system (IC50=0.2 uM). IC50 Value: 0.2 uM [1] Target: PDE3A in vitro: Cilostazol caused a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency.

  • Chemical Name: Deltarasin
    CAS No.: 1440898-82-7 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (S)-1-benzyl-2-(4-(2-(2-phe... Quality Control & MSDS Files:
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    High affinity PDE<span class='symbol'>&#948;</span>-KRAS interaction inhibitor (K<sub>d</sub> = 41 nM); binds to PDE<span class='symbol'>&#948;</span>. Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

  • Chemical Name: JW 55
    CAS No.: 664993-53-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: JW55;JW-55; N-(4-(((4-(4-me... Quality Control & MSDS Files:
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    JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).

  • Chemical Name: Raloxifene (hydrochloride)
    CAS No.: 82640-04-8 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: [6-Hydroxy-2-(4-hydroxyphen... Quality Control & MSDS Files:
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    RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist. Target: Estrogen receptor Approved: September 14, 2007 Raloxifene activates TGF beta 3 promoter as a full agonist at nanomolar concentrations, and raloxifene inhibits the estrogen response element-containing vitellogenin promoter expression as...

  • Chemical Name: Bendamustine hydrochloride
    CAS No.: 3543-75-7 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 1-Methyl-5-bis(2-chloroethy... Quality Control & MSDS Files:
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    Cytostatic agent that displays activity in non-Hodgkin&#39;s lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

  • Chemical Name: (&#177;)-Bisoprolol hemifumarate
    CAS No.: 104344-23-2 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Bisoprolol hemifumarate sal... Quality Control & MSDS Files:
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    A selective <span class='symbol'>&beta;</span><sub>1</sub>-adrenergic antagonist. Has a K<sub>d</sub> of 2-3 nM at the <span class='symbol'>&beta;</span><sub>1</sub> receptor and a <span class='symbol'>&beta;</span><sub>1</sub>/<span class='symbol'>&beta;</span><sub>2</sub> selectivity of approximately 100-fold.

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