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Tocris Bioscience Inc.

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Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Nicorandil
    CAS No.: 65141-46-0 Purity: Appearances: White to off-white Solid
    Brand:Tocris Synonyms: N-[2-(Nitroxy)ethyl]-3-pyri... Quality Control & MSDS Files:
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    K<sub>ir</sub>6 (K<sub>ATP</sub>) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K<sub>ir</sub>6 channels (EC<sub>50</sub> values are 10 and &gt; 500 <span class='symbol'>&#956;</span>M respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary a...

  • Chemical Name: Nefiracetam
    CAS No.: 77191-36-7 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: DM9384;Translon;DZL-221;DZL... Quality Control & MSDS Files:
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    Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model <em>in vivo</em>.

  • Chemical Name: Primidone
    CAS No.: 125-33-7 Purity: Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 2-Deoxyphenobarbital; 5-Phe... Quality Control & MSDS Files:
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    Anticonvulsant.

  • Chemical Name: Irsogladine maleate
    CAS No.: 84504-69-8 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: 2,4-Diamino-6-(2,5-dichloro... Quality Control & MSDS Files:
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    Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits <em>in ...

  • Chemical Name: Sulfisoxazole
    CAS No.: 127-69-5 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 3,4-Dimethyl-5-sulfanilamid... Quality Control & MSDS Files:
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    A selective ET<sub>A</sub> endothelin receptor antagonist (IC<sub>50</sub> values are 600 and 2200 nM for ET<sub>A</sub> and ET<sub>B</sub> receptors respectively).

  • Chemical Name: Tropicamide
    CAS No.: 1508-75-4 Purity: #98 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: N-Ethyl-3-hydroxy-2-phenyl-... Quality Control & MSDS Files:
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    M<sub>4</sub> selective muscarinic receptor antagonist.

  • Chemical Name: Dipyridamole
    CAS No.: 58-32-2 Purity: #99 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: 2,6-Bis(diethanolamino)-4,8... Quality Control & MSDS Files:
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    Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC<sub>50</sub> values are 0.37, 0.38, 0.45, 0.9 and 4.5 <span class='symbol'>&mu;</span>M? for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC<sub>50</sub> = 144.8 nM and K<sub>i</sub> = 8.18 nM for ENT1).

  • Chemical Name: (<em>S</em>)-(-)-Carbidopa
    CAS No.: 28860-95-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 3-(3,4-Dihydroxyphenyl)-2-h... Quality Control & MSDS Files:
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    Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

  • Chemical Name: Felodipine
    CAS No.: 72509-76-3 Purity: #98 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: Plendil;Renedil;Feloday; 3-... Quality Control & MSDS Files:
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    L-type Ca<sup>2+</sup> channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

  • Chemical Name: Dapoxetine hydrochloride
    CAS No.: 129938-20-1 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: (1S)-N,N-Dimethyl-3-naphtha... Quality Control & MSDS Files:
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    Selective serotonin reuptake inhibitor (SSRI).

  • Chemical Name: Diphenhydramine hydrochloride
    CAS No.: 147-24-0 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Benzhydramine hydrochloride... Quality Control & MSDS Files:
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    H<sub>1</sub> receptor antagonist. Antihistamine.

  • Chemical Name: Metoprolol tartrate
    CAS No.: 56392-17-7 Purity: #99 % Appearances:
    Brand:Tocris Synonyms: Lopressor; 1-(isopropylamin... Quality Control & MSDS Files:
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    Selective <span class='symbol'>&#946;</span><sub>1</sub>-adrenoceptor antagonist (K<sub>i</sub> values are 47, 2960 and 10100 nM for <span class='symbol'>&#946;</span><sub>1</sub>, <span class='symbol'>&#946;</span><sub>2</sub> and <span class='symbol'>&#946;</span><sub>3</sub> adrenoceptors respectively). Inhibits spontaneous endo...

  • Chemical Name: Clemastine fumarate
    CAS No.: 14976-57-9 Purity: #98 % Appearances: Light yellow to yellow Liquid
    Brand:Tocris Synonyms: (2R)-2-[2-[(1R)-1-(4-Chloro... Quality Control & MSDS Files:
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    H<sub>1</sub>-receptor antagonist. Clinically-used antihistamine.

  • Chemical Name: ONO 1078
    CAS No.: 103177-37-3 Purity: #99 % Appearances: white Solid
    Brand:Tocris Synonyms: ONO 1078;Ultair;ONO-1078; N... Quality Control & MSDS Files:
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    Selective cysteinyl leukotriene receptor 1 (CysLT<sub>1</sub>) antagonist (IC<sub>50</sub> values are ~ 4 - 7 and 3620 nM for CysLT<sub>1</sub> and CysLT<sub>2</sub> respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

  • Chemical Name: Clofibrate
    CAS No.: 637-07-0 Purity: Appearances: Colorless to light yellow Liquid
    Brand:Tocris Synonyms: Ethyl 2-(4-chlorophenoxy)-2... Quality Control & MSDS Files:
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    PPAR agonist (EC<sub>50</sub> values are 50, 500 and &gt; 100 <span class='symbol'>&mu;</span>M at PPAR<span class='symbol'>&alpha;</span>, PPAR<span class='symbol'>&gamma;</span> and PPAR<span class='symbol'>&delta;</span> respectively). Antihyperlipoproteinemic.

  • Chemical Name: Amiloride hydrochloride
    CAS No.: 2016-88-8 Purity: #98 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: N-Amidino-3,5-diamino-6-chl... Quality Control & MSDS Files:
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    Na<sup>+</sup> channel blocker. Defines the I<sub>2A</sub>-amiloride sensitive and I<sub>2B</sub>-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na<sup>+</sup>/H<sup>+</sup> exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has n...

  • Chemical Name: Nifedipine
    CAS No.: 21829-25-4 Purity: #98 % Appearances: Light yellow to yellow Solid
    Brand:Tocris Synonyms: Dimethyl 1,4-dihydro-2,6-di... Quality Control & MSDS Files:
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    L-type calcium channel blocker.

  • Chemical Name: Acipimox
    CAS No.: 51037-30-0 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: 5-Methylpyrazine-2-carboxyl... Quality Control & MSDS Files:
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    Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

  • Chemical Name: Acetylcholine chloride
    CAS No.: 60-31-1 Purity: Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Ach;ACh chloride Quality Control & MSDS Files:
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    Endogenous neurotransmitter. Acts at nicotinic and muscarinic acetylcholine receptors.

  • Chemical Name: Ranitidine hydrochloride
    CAS No.: 66357-59-3 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: N-[2-[[5-[(dimethylamino)me... Quality Control & MSDS Files:
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    Potent, selective and competitive histamine H<sub>2</sub> receptor antagonist (pA<sub>2</sub> = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food <em>in vivo</em>. Also inhibits aspirin-induced gastric lesions.

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