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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: Olopatadine hydrochloride
    CAS No.: 140462-76-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (Z)-11-[3-(Dimethylamino)pr... Quality Control & MSDS Files:
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    Histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

  • Chemical Name: Nitrendipine
    CAS No.: 39562-70-4 Purity: Appearances: light yellow to green yellow Solid
    Brand: Synonyms: Ethyl methyl 1,4-dihydro-2,... Quality Control & MSDS Files:
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    L-type calcium channel blocker.

  • Chemical Name: Nateglinide
    CAS No.: 105816-04-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Starlix;Fastic;Starsis;A416... Quality Control & MSDS Files:
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    Kir6 (KATP) blocker. Exhibits in vitro tissue selectivity for pancreatic β-cell-type Kir6 channels over cardiovascular Kir6 channels; displays high affinity for SUR1/Kir6.2 channels. Hypoglycemic agent; stimulates insulin secretion from pancreatic β-cells by increasing cytosolic Ca2+ concentration. Also agonist at the orphan receptor M...

  • Chemical Name: Mycophenolic acid
    CAS No.: 24280-93-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Mycophenolate;Myfortic; (E)... Quality Control & MSDS Files:
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    Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

  • Chemical Name: Loperamide hydrochloride
    CAS No.: 34552-83-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Imodium; 4-(4-(4-chlorophen... Quality Control & MSDS Files:
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    High affinity μ-opioid receptor agonist with peripheral selectivity (Ki values are 2, 48 and 1156 nM for μ-, δ- and κ-opioid receptors respectively). Antidiarrhoeal and antihyperalgesic agent. Also a Ca2+ channel blocker; at low micromolar concentrations it blocks broad spectrum neuronal HVA Ca2+ channels and at higher concentrations i...

  • Chemical Name: Domperidone
    CAS No.: 57808-66-9 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Motilium;Motillium;Motinorm... Quality Control & MSDS Files:
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    Peripheral dopamine D<sub>2</sub>-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED<sub>50</sub> values are 0.003 and 0.03 mg/kg f...

  • Chemical Name: Clindamycin hydrochloride
    CAS No.: 21462-39-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (2S,4R)-N-((1S,2S)-2-chloro... Quality Control & MSDS Files:
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    Lincosamide antibiotic. Inhibits protein synthesis by binding to the 50S ribosomal subunit and preventing early peptide chain elongation in bacteria.

  • Chemical Name: Clonidine hydrochloride
    CAS No.: 4205-91-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-(2,6-Dichloroanilino)-2-i... Quality Control & MSDS Files:
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    Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

  • Chemical Name: Bupropion hydrochloride
    CAS No.: 31677-93-7 Purity: Appearances:
    Brand: Synonyms: Amfebutamone hydrochloride;... Quality Control & MSDS Files:
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    Non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

  • Chemical Name: ID-8
    CAS No.: 147591-46-6 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ID 8;ID8; 1-(4-methoxypheny... Quality Control & MSDS Files:
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    ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. IC50 Value: Target: DYRK in vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology.

  • Chemical Name: Eprosartan (mesylate)
    CAS No.: 144143-96-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-[[2-Butyl-5-(2-carboxy-3-... Quality Control & MSDS Files:
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    Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

  • Chemical Name: (S)-(+)-Rolipram
    CAS No.: 85416-73-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (+)-Rolipram;(S)-Rolipram; ... Quality Control & MSDS Files:
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    Less active enantiomer of the PDE4 inhibitor Rolipram. Racemate and R-enantiomer also available.

  • Chemical Name: D-(+)-Glucose
    CAS No.: 50-99-7 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: D-Glucose anhydrous; Dextro... Quality Control & MSDS Files:
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    Naturally occurring monosaccharide.

  • Chemical Name: Probucol
    CAS No.: 23288-49-5 Purity: #99 % Appearances: White to off-white Solid
    Brand:Tocris Synonyms: Lorelco; 4,4'-(propane-2,2-... Quality Control & MSDS Files:
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    Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

  • Chemical Name: Ibutilide hemifumarate
    CAS No.: 122647-32-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N-[4-[4-(ethyl-heptyl-amino... Quality Control & MSDS Files:
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    Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT.

  • Chemical Name: Gabexate mesylate
    CAS No.: 56974-61-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: FOY; ethyl 4-((6-guanidinoh... Quality Control & MSDS Files:
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    Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation.

  • Chemical Name: GSK 2830371
    CAS No.: 1404456-53-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GSK2830371;GSK-2830371; (S)... Quality Control & MSDS Files:
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    Potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Orally...

  • Chemical Name: NSC 405020
    CAS No.: 7497-07-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: NSC405020;NSC-405020; 3,4-d... Quality Control & MSDS Files:
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    Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

  • Chemical Name: IWP L6
    CAS No.: 1427782-89-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: IWP-L6; 2-((4-oxo-3-phenyl-... Quality Control & MSDS Files:
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    Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

  • Chemical Name: Dexmedetomidine hydrochloride
    CAS No.: 145108-58-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-((S)-alpha,2,3-Trimethylb... Quality Control & MSDS Files:
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    Active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedativ...

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