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Tocris Bioscience Inc.

4828

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: (R)-(+)-Etomoxir (sodium salt)
    CAS No.: 828934-41-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (+)-Etomoxir sodium salt; s... Quality Control & MSDS Files:
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    (R)-(+)-Etomoxir (sodium salt) is a potent inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

  • Chemical Name: RGDS peptide
    CAS No.: 91037-65-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RGDS peptide;Fibronectin In... Quality Control & MSDS Files:
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    Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.

  • Chemical Name: Liothyronine sodium
    CAS No.: 55-06-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: T3 Sodium salt;Sodium L-3,3... Quality Control & MSDS Files:
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    Thyroid hormone (T3) analog. Promotes differentiation of mesenchymal stem cells (MSCs) into adipogenic cells in vitro.

  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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    Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Ca...

  • Chemical Name: (R)-(-)-Rolipram
    CAS No.: 85416-75-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (R)-Rolipram;(-)-Rolipram; ... Quality Control & MSDS Files:
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    More active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer. Available as part of the Phosphodiesterase Inhibitor Tocriset™. Racemate and S-enantiomer also available.

  • Chemical Name: K 02288
    CAS No.: 1431985-92-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: K-02288; K 02288; K 02288. Quality Control & MSDS Files:
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    Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC50 values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). Reduces BMP4-induced Smad1/5/8 phosphorylation in vitro (IC50 = 100 nM) and induces dorsalization of zebrafish embryos.

  • Chemical Name: AZ 191
    CAS No.: 1594092-37-1 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: AZ 191; N-(2-methoxy-4-(4-m... Quality Control & MSDS Files:
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    Potent DYRK1B inhibitor (IC50 values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced Gi phase cell cycle arrest in Panc-1 cells in vitro.

  • Chemical Name: MI 2
    CAS No.: 1047953-91-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: MALT1 inhibitor Quality Control & MSDS Files:
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    MI 2 (MALT1 inhibitor) is an irreversible <b>MALT1</b> protease inhibitor with an <b>IC<sub>50</sub></b> of 5.84 μM.

  • Chemical Name: CID 16020046
    CAS No.: 834903-43-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: CID16020046;CID-16020046; 4... Quality Control & MSDS Files:
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    CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM. IC50 value: 0.15 uM [1] Target: GPR55 antagonist In yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation.

  • Chemical Name: SN 2
    CAS No.: 823218-99-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SN2;SN-2; 3-mesityl-3a,4,5,... Quality Control & MSDS Files:
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    Selective TRPML3 channel activator (EC50 = 1.13 μM).

  • Chemical Name: MIM1
    CAS No.: Purity: Appearances: White to off-white Solid
    Brand: Synonyms: MIM 1;MIM-1;Inhibitor of Mc... Quality Control & MSDS Files:
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    Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro.

  • Chemical Name: LDN 27219
    CAS No.: 312946-37-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: LDN 27219;LDN 27219; 2-((4-... Quality Control & MSDS Files:
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    Transglutaminase 2 (TG2) inhibitor (IC50 = 0.25 μM). Binds at GTPase site; reversible.

  • Chemical Name: ISO-1
    CAS No.: 478336-92-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: ISO 1;ISO1;MIF Antagonist; ... Quality Control & MSDS Files:
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    ISO-1 is an inhibitor of MIF d-dopachrome tautomerase activity with an IC50 of about 7 uM. IC50 value: 7 uM [1] Target: MIF inhibitor in vitro: ISO-1 inhibited MIF tautomerase activity in a dose-dependent manner with an IC50 of about 7 μM, but the non-hydroxylated phenyl analog (compound 2) was 10–15 times less potent.

  • Chemical Name: AK 7
    CAS No.: 420831-40-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AK 7;AK7; 3-(azepan-1-ylsul... Quality Control & MSDS Files:
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    Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

  • Chemical Name: BTS
    CAS No.: 1576-37-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N-Benzyl-p-toluenesulfonami... Quality Control & MSDS Files:
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    Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

  • Chemical Name: VU 0240551
    CAS No.: 893990-34-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VU0240551;VU-0240551; N-(4-... Quality Control & MSDS Files:
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    Inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.

  • Chemical Name: Eltoprazine hydrochloride
    CAS No.: 98206-09-8 Purity: Appearances:
    Brand: Synonyms: DU-28853 hydrochloride;DU28... Quality Control & MSDS Files:
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    5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo.

  • Chemical Name: FR 180204
    CAS No.: 865362-74-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: FR 180204;FR-180204; 5-(2-p... Quality Control & MSDS Files:
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    Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells ...

  • Chemical Name: ML 347
    CAS No.: 1062368-49-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ML 347;ML-347;LDN-193719;LD... Quality Control & MSDS Files:
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    Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).

  • Chemical Name: CZC 25146
    CAS No.: 1191911-26-8 Purity: Appearances: pale purple to purple Solid
    Brand: Synonyms: CZC25146;CZC 25146; N-(2-((... Quality Control & MSDS Files:
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    Potent LRRK2 inhibitor (IC50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.