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Tocris Bioscience Inc.

2800

Basic Information

Company Name:Tocris Bioscience Inc.

Business Type:Chemical manufacturer since 1982

Total NO.Employees:50

Country/Region:USA

Certificates:

Year Established: 1982

Introduction of Tocris Bioscience Inc.

Tocris Bioscience is the trading name of Tocris Cookson Ltd., which is headquartered in Bristol, UK. There are approximately 50 employees in the company. In May 2011 Tocris Bioscience was wholly acquired by R&D Systems, headquartered in Minneapolis, MN, USA.

Web: www.tocris.com TEL:+1 (636) 207-7651 Fax:+1 (636) 207-7683 Email:[email protected]; [email protected]

Products of Tocris Bioscience Inc.

  • Chemical Name: (R)-(+)-Etomoxir (sodium salt)
    CAS No.: 828934-41-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (+)-Etomoxir sodium salt; s... Quality Control & MSDS Files:
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    Brief introduction:

    (R)-(+)-Etomoxir (sodium salt) is a potent inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

  • Chemical Name: Arg-Gly-Asp-Ser
    CAS No.: 91037-65-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RGDS peptide;Fibronectin In... Quality Control & MSDS Files:
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    Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.

  • Chemical Name: 3,3',5-Triiodo-L-thyronine (sodium)
    CAS No.: 55-06-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: T3 Sodium salt;Sodium L-3,3... Quality Control & MSDS Files:
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    3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to <b>β1 thyroid hormone receptor</b> (<b>TRβ1</b>), and activates its activity.

  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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  • Chemical Name: (R)-(-)-Rolipram
    CAS No.: 85416-75-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (R)-Rolipram;(-)-Rolipram; ... Quality Control & MSDS Files:
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    (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. IC50 value: Target: PDE4 in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 ...

  • Chemical Name: K02288
    CAS No.: 1431985-92-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Quality Control & MSDS Files:
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    Brief introduction:

    K02288 is a potent inhibitor of <b>ALK</b>, and inhibits ALK1/2/3/6 with <b>IC<sub>50</sub></b>s of 1.8/1.1/34.4/6.3 nM; less potent against ALK4/5, with IC<sub>50</sub>s of 302 nM and 321 nM.

  • Chemical Name: AZ191
    CAS No.: 1594092-37-1 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: AZ 191; N-(2-methoxy-4-(4-m... Quality Control & MSDS Files:
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  • Chemical Name: MI 2
    CAS No.: 1047953-91-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: MALT1 inhibitor Quality Control & MSDS Files:
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    MI 2 (MALT1 inhibitor) is an irreversible <b>MALT1</b> protease inhibitor with an <b>IC<sub>50</sub></b> of 5.84 μM.

  • Chemical Name: CID 16020046
    CAS No.: 834903-43-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: CID16020046;CID-16020046; 4... Quality Control & MSDS Files:
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    CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM. IC50 value: 0.15 uM [1] Target: GPR55 antagonist In yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation.

  • Chemical Name: SN 2
    CAS No.: 823218-99-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SN2;SN-2; 3-mesityl-3a,4,5,... Quality Control & MSDS Files:
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    SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM. IC50 value: 1.13 uM (EC50) Target: TRPML3 activator Compounds SF21, SF-41, and SN-2 elicited a much more rapid increase than the other compounds, with SF-33 and SF 51 displaying the slowest kinetics.

  • Chemical Name: LDN-27219
    CAS No.: 312946-37-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: LDN 27219;LDN 27219; 2-((4-... Quality Control & MSDS Files:
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    LDN-27219 is a potent inhibitor of hTGase(Tissue transglutaminase) with an IC50 of 0.6 uM. IC50 value: 0.6 uM [1] Target: hTGase inhibitor LDN-27219 is a potent inhibitor of the enzyme(hTGase), producing 100% inhibition at the screening concentration of 10 uM.

  • Chemical Name: ISO-1
    CAS No.: 478336-92-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: ISO 1;ISO1;MIF Antagonist; ... Quality Control & MSDS Files:
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    ISO-1 is an inhibitor of MIF d-dopachrome tautomerase activity with an IC50 of about 7 uM. IC50 value: 7 uM [1] Target: MIF inhibitor in vitro: ISO-1 inhibited MIF tautomerase activity in a dose-dependent manner with an IC50 of about 7 μM, but the non-hydroxylated phenyl analog (compound 2) was 10–15 times less potent.

  • Chemical Name: AK-7
    CAS No.: 420831-40-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AK 7;AK7; 3-(azepan-1-ylsul... Quality Control & MSDS Files:
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    Brief introduction:

    AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models. IC50 value: Target: SIRT2 AK-7 treated R6/2 mice performed significantly better than vehicle treated littermates on the accelerating rotarod at 8 and 11 weeks of age.

  • Chemical Name: BTS
    CAS No.: 1576-37-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N-Benzyl-p-toluenesulfonami... Quality Control & MSDS Files:
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    BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility.

  • Chemical Name: VU 0240551
    CAS No.: 893990-34-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VU0240551;VU-0240551; N-(4-... Quality Control & MSDS Files:
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    VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). IC50 value: 560 nM [1] Target: K-Cl cotransporter(KCC2) VU 0240551 exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl.

  • Chemical Name: Eltoprazine (hydrochloride)
    CAS No.: 98206-09-8 Purity: Appearances:
    Brand: Synonyms: DU-28853 hydrochloride;DU28... Quality Control & MSDS Files:
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    Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. IC50 value: Target: 5-HT1A/1B agonist; 5-HT2C antagonist in vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation c...

  • Chemical Name: FR 180204
    CAS No.: 865362-74-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: FR 180204;FR-180204; 5-(2-p... Quality Control & MSDS Files:
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    FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively. IC50 value: 0.31 uM/0.14 uM(Ki for ERK1/ERK2); 0.51uM/0.33 μM(ERK1/ERK2) [1] [2] Target: ERK1/2 inhibitor in vi...

  • Chemical Name: ML347
    CAS No.: 1062368-49-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ML 347;ML-347;LDN-193719;LD... Quality Control & MSDS Files:
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    Brief introduction:

    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs.

  • Chemical Name: CFTR(inh)-172
    CAS No.: 307510-92-5 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: CFTR Inhibitor-172;CFTRinh-... Quality Control & MSDS Files:
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    Brief introduction:

    CFTR(inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki approximately 300 nM.

  • Chemical Name: HLM006474
    CAS No.: 353519-63-8 Purity: Appearances:
    Brand: Synonyms: HLM 006474;HLM-006474; 7-((... Quality Control & MSDS Files:
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    HLM006474 is a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system; interferes with E2F activity. IC50 value: 29.8 μM(EC50 in vivo) Target: E2F inhibitor in vivo: HLM006474 is not specific to E2F4 and appears to inhibit binding by all E2F complexes.