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Sigma-Aldrich, Inc.

1130

Basic Information

Company Name:Sigma-Aldrich, Inc.

Business Type:Chemical manufacturer since 1992

Total NO.Employees:

Country/Region:USA

Certificates:

Year Established:

Introduction of Sigma-Aldrich, Inc.

Web: www.sigmaaldrich.com TEL:+86 (21) 6141-5566 / 800-819-3336 Fax: Email:[email protected]

Products of Sigma-Aldrich, Inc.

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    Brief introduction:

    IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC<sub>50</sub></b> of 53 nM, and also enhances Wnt signalling.

  • Chemical Name: Arg-Gly-Asp-Ser
    CAS No.: 91037-65-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RGDS peptide;Fibronectin In... Quality Control & MSDS Files:
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    Brief introduction:

    Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.

  • Chemical Name: Buparvaquone
    CAS No.: 88426-33-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Butalex; 2-((4-(tert-butyl)... Quality Control & MSDS Files:
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    Brief introduction:

    Buparvaquone(Butalex) is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone; it is a promising compound for the therapy and prophylaxis of all forms of theileriosis.

  • Chemical Name: 3,3',5-Triiodo-L-thyronine (sodium)
    CAS No.: 55-06-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: T3 Sodium salt;Sodium L-3,3... Quality Control & MSDS Files:
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    Brief introduction:

    3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to <b>β1 thyroid hormone receptor</b> (<b>TRβ1</b>), and activates its activity.

  • Chemical Name: Doxylamine (succinate)
    CAS No.: 562-10-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N,N-Dimethyl-2-[1-phenyl-1-... Quality Control & MSDS Files:
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    Brief introduction:

    Doxylamine is a first generation antihistamine; can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief.

  • Chemical Name: K02288
    CAS No.: 1431985-92-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: K-02288; K 02288; K 02288. Quality Control & MSDS Files:
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    Brief introduction:

    K02288 is a potent inhibitor of <b>ALK</b>, and inhibits ALK1/2/3/6 with <b>IC<sub>50</sub></b>s of 1.8/1.1/34.4/6.3 nM; less potent against ALK4/5, with IC<sub>50</sub>s of 302 nM and 321 nM.

  • Chemical Name: AZ191
    CAS No.: 1594092-37-1 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: AZ 191; N-(2-methoxy-4-(4-m... Quality Control & MSDS Files:
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    Brief introduction:

    AZ191 is a potent and selective <b>DYRK1B</b> inhibitor with <b>IC50</b> of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

  • Chemical Name: AK-7
    CAS No.: 420831-40-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AK 7;AK7; 3-(azepan-1-ylsul... Quality Control & MSDS Files:
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    Brief introduction:

    AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models. IC50 value: Target: SIRT2 AK-7 treated R6/2 mice performed significantly better than vehicle treated littermates on the accelerating rotarod at 8 and 11 weeks of age.

  • Chemical Name: VU 0240551
    CAS No.: 893990-34-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VU0240551;VU-0240551; N-(4-... Quality Control & MSDS Files:
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    Brief introduction:

    VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). IC50 value: 560 nM [1] Target: K-Cl cotransporter(KCC2) VU 0240551 exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl.

  • Chemical Name: ML347
    CAS No.: 1062368-49-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ML 347;ML-347;LDN-193719;LD... Quality Control & MSDS Files:
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    Brief introduction:

    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs.

  • Chemical Name: Oxybenzone
    CAS No.: 131-57-7 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 2-Hydroxy-4-methoxybenzophe... Quality Control & MSDS Files:
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    Brief introduction:

    Oxybenzone(Eusolex 4360; Escalol 567) is an organic compound used in sunscreens; provides broad-spectrum ultraviolet coverage, including UVB and short-wave UVA rays.

  • Chemical Name: Dafadine-A
    CAS No.: 1065506-69-5 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Dafadine A; (5-((2,6-dimeth... Quality Control & MSDS Files:
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    Brief introduction:

    Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).

  • Chemical Name: Tyrphostin A1
    CAS No.: 2826-26-8 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Tyrphostin 1;AG9; 2-(4-meth... Quality Control & MSDS Files:
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    Brief introduction:

    Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value: Target: IL-12 production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM.

  • Chemical Name: Tolazoline
    CAS No.: 59-98-3 Purity: Appearances:
    Brand: Synonyms: 2-Benzylimidazoline; 2-Benz... Quality Control & MSDS Files:
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    Brief introduction:

    Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist. IC50 value: Target: α-adrenoceptor antagonist Tolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product.

  • Chemical Name: HLM006474
    CAS No.: 353519-63-8 Purity: Appearances:
    Brand: Synonyms: HLM 006474;HLM-006474; 7-((... Quality Control & MSDS Files:
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    Brief introduction:

    HLM006474 is a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system; interferes with E2F activity. IC50 value: 29.8 μM(EC50 in vivo) Target: E2F inhibitor in vivo: HLM006474 is not specific to E2F4 and appears to inhibit binding by all E2F complexes.

  • Chemical Name: SJ-172550
    CAS No.: 431979-47-4 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: SJ172550;SJ 172550; (E)-met... Quality Control & MSDS Files:
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    Brief introduction:

    SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. IC50 value: 0.84 uM(EC50) [1] Target: MDMX inhibitor in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX prot...

  • Chemical Name: ITX3
    CAS No.: 347323-96-0 Purity: Appearances:
    Brand: Synonyms: ITX 3;ITX-3; (E)-2-((2,5-di... Quality Control & MSDS Files:
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    Brief introduction:

    ITX3 is a specific and nontoxic inhibitor of the TrioN (N-terminal GEF domain of the multidomain Trio protein) with IC50 of 76 uM; inhibits TrioN-stimulated RhoG exchange in vitro. IC50 value: 76 uM [1] Target: TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation w...

  • Chemical Name: DMH-1
    CAS No.: 1206711-16-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: DMH1;DMH 1; 4-(6-(4-isoprop... Quality Control & MSDS Files:
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    Brief introduction:

    DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2. IC50 value: 27/107.9/<5 nM(ALK1/2/3) [1] Target: ALK inhibitor DMH-1 shows the most selectivity within these three compounds(LDN-193189, DMH-1 and dorsomorphin) [1].

  • Chemical Name: Oncrasin-1
    CAS No.: 75629-57-1 Purity: Appearances: Light yellow to earth yellow Solid
    Brand: Synonyms: Oncrasin 1;Oncrasin1; 1-(4-... Quality Control & MSDS Files:
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    Brief introduction:

    Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1] Target: human lung can...

  • Chemical Name: EHT 1864
    CAS No.: 754240-09-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: EHT1864;EHT-1864; 2-(morpho... Quality Control & MSDS Files:
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    Brief introduction:

    EHT 1864 is a small molecule inhibitor of Rac1 signaling; modulate γ-Secretase-mediated APP processing. IC50 value: Target: Rac1 inhibitor in vitro: EHT 1864 blocks Aβ 40 and Aβ 42 production but does not impact sAPPα levels and does not inhibit γ-secretase.