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Chemical Name:
Lonidamine
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CAS No.:
50264-69-2
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Appearances: White to off-white Solid |
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Synonyms: 1-(2,4-Dichlorobenzyl)-1H-i... |
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Brief introduction:
Lonidamine is an orally administered small molecule hexokinase inactivator.
Target: Others
Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells.
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Chemical Name:
Hydralazine (hydrochloride)
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CAS No.:
304-20-1
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Appearances: White to off-white Solid |
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Synonyms: 1-Hydrazinophthalazine hydr... |
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Brief introduction:
Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.
Target: Others
Hydralazine (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.
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Chemical Name:
Atracurium (besylate)
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CAS No.:
64228-81-5
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 2,2'-[1,5-Pentanediylbis[ox... |
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Brief introduction:
Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
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Chemical Name:
Ifosfamide
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CAS No.:
3778-73-2
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Purity: |
Appearances: White to off-white solid |
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Synonyms: 3-(2-Chloroethyl)-2-[(2-chl... |
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Brief introduction:
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
IC50 Value: 1mM (in MCF-7 and MDA-MB231 cell lines, at 48 hr) [1]
Target: DNA alkylating agent
Ifosfamide (IF) is a prodrug requiring metabolic activation to produce 4-hydroxyifosfamide (4-OHIF), which breaks down to form isophosphoramide mustard.
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Chemical Name:
Mesna
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CAS No.:
19767-45-4
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Purity: |
Appearances: White to off-white solid |
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Synonyms: Sodium 2-mercaptoethanesulf... |
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Brief introduction:
2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide.
IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in P...
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Chemical Name:
Oxaliplatin
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CAS No.:
61825-94-3
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: trans-L-Diaminocyclohexane ... |
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Brief introduction:
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
IC50 Value:
Target: DNA crosslinker
in vitro: The main mechanism of action of Oxaliplatin is mediated through the formation of DNA–adducts.
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Chemical Name:
Milrinone
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CAS No.:
78415-72-2
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Corotrope;Primacor IV;Win 4... |
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Brief introduction:
Milrinone(Win 47203) is a PDE3 inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
IC50 Value: 2 mM( inhibiting human platelet aggregation) [3]
Target: PDE3
in vitro: Milrinone inhibited PDE4 in addition to PDE3 activity.
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Chemical Name:
Vinorelbine
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CAS No.:
71486-22-1
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Synonyms: Navelbine;Navelbine base;KW... |
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Brief introduction:
Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
IC50 value:
Target: Anti-mitotic
Vinorelbine (Navelbine) is the first 5′NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM.
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Chemical Name:
Hydralazine
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CAS No.:
86-54-4
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Synonyms: Apresoline; |
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Chemical Name:
9-Aminoacridine
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CAS No.:
90-45-9
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: 9AA; Aminacrin; Aminacrine;... |
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Brief introduction:
Yellow needles. Free soluble in alcohol.
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Chemical Name:
N,N-Dimethylbenzylamine
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CAS No.:
103-83-3
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Synonyms: Benzyldimethylamine; BDMA; ... |
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Brief introduction:
A colorless to light yellow liquid with an aromatic odor. Slightly less dense than water and slightly soluble in water. Flash point approximately 140°F. Corrosive to skin, eyes and mucous membranes. Slightly toxic by ingestion, skin absorption and inhalation. Used in the manufacture of adhesives and other chemicals.
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Chemical Name:
Acridin-9(10H)-one
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CAS No.:
578-95-0
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Chemical Name:
2-Mercaptopyridine
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CAS No.:
2637-34-5
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Synonyms: 2-Pyridinethiol; 2-Pyridyl ... |
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Chemical Name:
2,2'-Thiodiethanethiol
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CAS No.:
3570-55-6
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Synonyms: 2-Mercaptoethyl sulfide; Bi... |
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