Ganyu Unitechemical Co., Ltd.

Lonidamine is an orally administered small molecule hexokinase inactivator. Target: Others Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells.

Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent. Target: Others Hydralazine (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. IC50 Value: 1mM (in MCF-7 and MDA-MB231 cell lines, at 48 hr) [1] Target: DNA alkylating agent Ifosfamide (IF) is a prodrug requiring metabolic activation to produce 4-hydroxyifosfamide (4-OHIF), which breaks down to form isophosphoramide mustard.

2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide. IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in P...

Oxaliplatin inhibits DNA synthesis by conforming DNA adducts. IC50 Value: Target: DNA crosslinker in vitro: The main mechanism of action of Oxaliplatin is mediated through the formation of DNA–adducts.

Milrinone(Win 47203) is a PDE3 inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation. IC50 Value: 2 mM( inhibiting human platelet aggregation) [3] Target: PDE3 in vitro: Milrinone inhibited PDE4 in addition to PDE3 activity.

Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. IC50 value: Target: Anti-mitotic Vinorelbine (Navelbine) is the first 5′NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM.

Yellow needles. Free soluble in alcohol.

A colorless to light yellow liquid with an aromatic odor. Slightly less dense than water and slightly soluble in water. Flash point approximately 140°F. Corrosive to skin, eyes and mucous membranes. Slightly toxic by ingestion, skin absorption and inhalation. Used in the manufacture of adhesives and other chemicals.