Enzo Life Sciences International Inc.

Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

PSI-7976, the isomer of PSI-7977(HY-15005), is an inhibitor of HCV RNA replication in the HCV replicon assay (EC50=1.07 uM). IC50 value: 1.07 uM (inhibit HCV RNA replication in clone A replicon cells) [1] Target: HCV; HCV NS5B RNA polymerase PSI-7851 contains a chiral phosphorous atom and therefore is a mixture of two diastereomers,...

Ellipticine hydrochloride is a potent antineoplastic agent; inhibits <b>DNA topoisomerase II</b> activities.

NS-398 is a selective inhibitor of <b>cyclooxygenase-2 (COX-2)</b>. The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.

PD168393 is an irreversible <b>EGFR</b> inhibitor with <b>IC50</b> of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.

Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.

Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate.

Magnolol, a natural lignan isolated from the stem bark of <i>Magnolia officinalis</i>, is a dual agonist of both <b>RXRα</b> and <b>PPARγ</b>, with <b>EC₅₀</b> values of 10.4 µM and 17.7 µM, respectively.

AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα. IC50 value: 33±10 nM [1] Target: PI3Kγ inhibitor in vitro: Compound 26 (AS-252424), a potent and selective small-molecule PI3Kγ inhibitor emerging from these efforts, was further profiled in three different cellula...

Sirtinol is a <b>sirtuin</b> inhibitor, with <b>IC₅₀</b>s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.

Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor). IC50 value: Target: Dopamine reuptake inhibitor At a cellular level, vanoxerine acts to block cardiac ion channels.

AS601245 is a <b>JNK</b> Inhibitor with <b>IC₅₀</b>s of 150, 220, and 70 nM for three JNK human isoforms (<b>hJNK1</b>, <b>hJNK2</b>, and <b>hJNK3</b>), respectively.

Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 0.17 μM and 3 nM, respectively.

(+)WIN 55212-2 mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. IC50 value: 62.3/3.3 nM (Ki,CB1/CB2) Target: Cannabinoid receptor In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM)...

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also showed slightly weaker activity for BRD4 (Kd=3.4 uM). IC50 value: 50 nM (p38α); 100 nM (p38β) [1] in vitro: SB202190 binds within the ATP pocket of the active kinase (Kd = 38...

SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM); competes with ATP. IC50 value: 9 nM (Ki) Target: GSK-3α SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M).

Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.

Desipramine hydrochloride is an inhibitor of <b>norepinephrine transporter</b> (<b>NET</b>), <b>5-HT transporter</b> (<b>SERT</b>) and <b>dopamine transporter</b> (<b>DAT</b>) with <b>K_i</b>s of 4, 61 and 78,720 nM, respectively.

Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with <b>IC₅₀</b> of 532.5 nM and 2880 nM for <b>protein synthesis</b> and <b>RNA synthesis</b> in vivo, respectively.