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Chemical Name:
Dansyl chloride
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CAS No.:
605-65-2
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Purity: |
Appearances: yellow to orange |
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Synonyms: 5-(Dimethylamino)naphthalen... |
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Chemical Name:
AG 825
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CAS No.:
149092-50-2
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Synonyms: Tyrphostin AG 825; (E)-3-(3... |
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Brief introduction:
Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
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Chemical Name:
PSI-7976
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CAS No.:
1190308-01-0
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: PSI7976;PSI 7976; (S)-isopr... |
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Brief introduction:
PSI-7976, the isomer of PSI-7977(HY-15005), is an inhibitor of HCV RNA replication in the HCV replicon assay (EC50=1.07 uM).
IC50 value: 1.07 uM (inhibit HCV RNA replication in clone A replicon cells) [1]
Target: HCV; HCV NS5B RNA polymerase
PSI-7851 contains a chiral phosphorous atom and therefore is a mixture of two diastereomers,...
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Chemical Name:
Ellipticine
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CAS No.:
519-23-3
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Synonyms: Ellipticine; 5,11-dimethyl-... |
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Brief introduction:
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits <b>DNA topoisomerase II</b> activities.
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Chemical Name:
NS-398
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CAS No.:
123653-11-2
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: N-(2-Cyclohexyloxy-4-nitrop... |
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Brief introduction:
NS-398 is a selective inhibitor of <b>cyclooxygenase-2 (COX-2)</b>. The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively.
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Chemical Name:
PD168393
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CAS No.:
194423-15-9
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Purity: |
Appearances: Light yellow to khaki Solid |
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Synonyms: PD168393; PD 168393; PD-168... |
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Brief introduction:
PD168393 is an irreversible <b>EGFR</b> inhibitor with <b>IC50</b> of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.
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Chemical Name:
Cantharidin
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CAS No.:
56-25-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Dimethyl-3,6-epoxyperhydrop... |
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Brief introduction:
Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.
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Chemical Name:
Epoxomicin
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CAS No.:
134381-21-8
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: BU 4061T; (2S,3S)-N-((2S,3R... |
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Brief introduction:
Epoxomicin is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate.
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Chemical Name:
Magnolol
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CAS No.:
528-43-8
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 5,5'-Diallyl-2,2'-biphenyld... |
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Brief introduction:
Magnolol, a natural lignan isolated from the stem bark of <i>Magnolia officinalis</i>, is a dual agonist of both <b>RXRα</b> and <b>PPARγ</b>, with <b>EC<sub>50</sub></b> values of 10.4 µM and 17.7 µM, respectively.
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Chemical Name:
AS-252424
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CAS No.:
900515-16-4
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: AS 252424;AS252424; (Z)-5-(... |
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Brief introduction:
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
IC50 value: 33±10 nM [1]
Target: PI3Kγ inhibitor
in vitro: Compound 26 (AS-252424), a potent and selective small-molecule PI3Kγ inhibitor emerging from these efforts, was further profiled in three different cellula...
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Chemical Name:
Sirtinol
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CAS No.:
410536-97-9
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: (E)-2-(((2-hydroxynaphthale... |
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Brief introduction:
Sirtinol is a <b>sirtuin</b> inhibitor, with <b>IC<sub>50</sub></b>s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
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Chemical Name:
Vanoxerine (dihydrochloride)
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CAS No.:
67469-78-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: GBR-12909 dihydrochloride; ... |
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Brief introduction:
Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).
IC50 value:
Target: Dopamine reuptake inhibitor
At a cellular level, vanoxerine acts to block cardiac ion channels.
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Chemical Name:
AS601245
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CAS No.:
345987-15-7
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: 2-(benzo[d]thiazol-2-yl)-2-... |
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Brief introduction:
AS601245 is a <b>JNK</b> Inhibitor with <b>IC<sub>50</sub></b>s of 150, 220, and 70 nM for three JNK human isoforms (<b>hJNK1</b>, <b>hJNK2</b>, and <b>hJNK3</b>), respectively.
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Chemical Name:
Wortmannin
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CAS No.:
19545-26-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: (+)-Wortmannin; KY 1242; [1... |
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Brief introduction:
Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 0.17 μM and 3 nM, respectively.
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Chemical Name:
WIN 55,212-2 (Mesylate)
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CAS No.:
131543-23-2
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Purity: |
Appearances: Light green to green Solid |
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Synonyms: (R)-(+)-[2,3-Dihydro-5-meth... |
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Brief introduction:
(+)WIN 55212-2 mesylate is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
IC50 value: 62.3/3.3 nM (Ki,CB1/CB2)
Target: Cannabinoid receptor
In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM)...
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Chemical Name:
SB 202190
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CAS No.:
152121-30-7
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Purity: |
Appearances: White to off-white solid |
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Synonyms: 4-(4-Fluorophenyl)-2-(4-hyd... |
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Brief introduction:
SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38α and p38β respectively; also showed slightly weaker activity for BRD4 (Kd=3.4 uM).
IC50 value: 50 nM (p38α); 100 nM (p38β) [1]
in vitro: SB202190 binds within the ATP pocket of the active kinase (Kd = 38...
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Chemical Name:
SB 216763
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CAS No.:
280744-09-4
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Purity: |
Appearances: Pink to red solid |
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Synonyms: SB-216763;SB216763; 3-(2,4-... |
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Brief introduction:
SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM); competes with ATP.
IC50 value: 9 nM (Ki)
Target: GSK-3α
SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M).
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Chemical Name:
Metyrapone
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CAS No.:
54-36-4
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Purity: |
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Synonyms: 2-methyl-1,2-di(pyridin-3-y... |
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Brief introduction:
Cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.
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Chemical Name:
Desipramine hydrochloride
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CAS No.:
58-28-6
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Purity: |
Appearances: white to off-white |
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Synonyms: Desmethylimipramine, Norimi... |
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Brief introduction:
Desipramine hydrochloride is an inhibitor of <b>norepinephrine transporter</b> (<b>NET</b>), <b>5-HT transporter</b> (<b>SERT</b>) and <b>dopamine transporter</b> (<b>DAT</b>) with <b>K<sub>i</sub></b>s of 4, 61 and 78,720 nM, respectively.
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Chemical Name:
Cycloheximide
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CAS No.:
66-81-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Naramycin A;Actidione |
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Brief introduction:
Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with <b>IC<sub>50</sub></b> of 532.5 nM and 2880 nM for <b>protein synthesis</b> and <b>RNA synthesis</b> in vivo, respectively.
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