Chongqing Yifutech Co., Ltd.

Ropinirole hydrochloride(SKF101468 hydrochloride) a selective dopamine D2 receptor inhibitor with IC50 of 29 nM. Target: Dopamine D2 Receptor Ropinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice.

Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. Target: Glucocorticoid Receptor Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1].

Bendamustine Hcl(SDX105; EP-3101) is a DNA-damaging agent with IC50 of 50 μM. Target: Others Approved: March 2008 Treatment with Bendamustine results in a 60% to 80% down-regulation of the mRNA expression of all three of these genes [polo-like kinase 1 (PLK-1), Aurora Kinase A, and cyclin B1] in SU-DHL-9 cells.

Budesonide is a glucocorticoid used in the management of asthma. Target: Glucocorticoid Receptor Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis.

Milrinone(Win 47203) is a PDE3 inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation. IC50 Value: 2 mM( inhibiting human platelet aggregation) [3] Target: PDE3 in vitro: Milrinone inhibited PDE4 in addition to PDE3 activity.

Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at the 5HT2A and 5-HT2B receptors.

Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). IC50 Value: Target: 5-HT Receptor Palonosetron is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course ...