Chengdu Tianyuan Natural Product Co., Ltd.

Secoisolariciresinol diglucoside is a plant lignan isolated from flaxseed, an antagonist of <b>platelet activating factor-receptor</b>, and used as an antioxidant.

Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. Target: 5-HT3 Receptor Ramosetron hydrochloride selectively blocks serotonin receptors (5-HT3).

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the <b>aryl hydrocarbon receptor</b> (<b>AhR</b>).

Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein (HDL) function, reduces farnesoid X receptor antagonist bile acids and the gene expression levels of sterol regulatory element binding protein 1c, acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1, and induces...

Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.

Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of <b>VEGF</b>/<b>VEGFR2</b>.

Topotecan Hcl (SKF 104864A; NSC 609669) is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. IC50 Value: 37-280 uM (Human glioma cell lines) [1] Target: Topoisomerase I in vitro: Human glioma cell lines (U87, U138 and U373) displayed different sensitivities to topotecan (IC50range: 0.0...

SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. IC50 Value: Target: topoisomerase I in vitro: Among TIs, SN-38 had the highest cytotoxicity towards OSCC cell lines, with a tumor specificity index of 1321 compared to mesenchymal cells and 22 co...

Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1. Target: Topoisomerase I Irinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I.

Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator. Target: Tyrosine Kinase; Estrogen Receptor Daidzein, one of the major soy phytoestrogens, had biphasic effects on osteogenesis and adipogenesis.

Irinotecan Hcl-trihydrate prevents DNA from unwinding by inhibition of topoisomerase 1. IC50 Value: 15.8 μM(LoVo cells); 5.17 μM(HT-29 cells) Target: Topoisomerase I in vitro: Irinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I.

Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. IC50 Value: It has been shown that genistein inhibits many type of cancers including prostat...

Levosimendan(OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Target: Others Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.