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Chemical Name:
Secoisolariciresinol diglucoside
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CAS No.:
158932-33-3
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Synonyms: SDG |
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Brief introduction:
Secoisolariciresinol diglucoside is a plant lignan isolated from flaxseed, an antagonist of <b>platelet activating factor-receptor</b>, and used as an antioxidant.
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Chemical Name:
Ramosetron (Hydrochloride)
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CAS No.:
132907-72-3
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Appearances: White to off-white Solid |
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Synonyms: (1-Methylindol-3-yl)-[(5R)-... |
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Brief introduction:
Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.
Target: 5-HT3 Receptor
Ramosetron hydrochloride selectively blocks serotonin receptors (5-HT3).
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Chemical Name:
10-Hydroxycamptothecine
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CAS No.:
67656-30-8
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Synonyms: 9-Hydroxycamptothecin; 9-Hy... |
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Chemical Name:
Diosmin
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CAS No.:
520-27-4
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Synonyms: 3',5,7-Trihydroxy-4'-methox... |
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Brief introduction:
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the <b>aryl hydrocarbon receptor</b> (<b>AhR</b>).
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Chemical Name:
Hyodeoxycholic acid
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CAS No.:
83-49-8
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Synonyms: 3alpha,6alpha-Dihydroxy-5be... |
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Brief introduction:
Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein (HDL) function, reduces farnesoid X receptor antagonist bile acids and the gene expression levels of sterol regulatory element binding protein 1c, acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1, and induces...
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Chemical Name:
Puerarin
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CAS No.:
3681-99-0
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Synonyms: 8-(beta-D-Glucopyranosyl-7-... |
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Brief introduction:
Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist.
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Chemical Name:
Tanshinone IIA
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CAS No.:
568-72-9
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Synonyms: 1,6,6-trimethyl-6,7,8,9-tet... |
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Brief introduction:
Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of <b>VEGF</b>/<b>VEGFR2</b>.
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Chemical Name:
Topotecan (Hydrochloride)
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CAS No.:
119413-54-6
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: (S)-10-[(Dimethylamino)meth... |
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Brief introduction:
Topotecan Hcl (SKF 104864A; NSC 609669) is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
IC50 Value: 37-280 uM (Human glioma cell lines) [1]
Target: Topoisomerase I
in vitro: Human glioma cell lines (U87, U138 and U373) displayed different sensitivities to topotecan (IC50range: 0.0...
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Chemical Name:
SN-38
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CAS No.:
86639-52-3
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Appearances: Light yellow to yellow Solid |
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Synonyms: SN 38; SN38;NK-012;NK012;NK... |
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Brief introduction:
SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
IC50 Value:
Target: topoisomerase I
in vitro: Among TIs, SN-38 had the highest cytotoxicity towards OSCC cell lines, with a tumor specificity index of 1321 compared to mesenchymal cells and 22 co...
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Chemical Name:
Irinotecan (hydrochloride)
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CAS No.:
100286-90-6
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Appearances: Light yellow to yellow Solid |
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Synonyms: CPT-11 hydrochloride;CPT 11... |
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Brief introduction:
Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.
Target: Topoisomerase I
Irinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I.
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Chemical Name:
Daidzein
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CAS No.:
486-66-8
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Appearances: White to off-white Solid |
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Synonyms: 4',7-Dihydroxyisoflavone; 7... |
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Brief introduction:
Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor activator.
Target: Tyrosine Kinase; Estrogen Receptor
Daidzein, one of the major soy phytoestrogens, had biphasic effects on osteogenesis and adipogenesis.
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Chemical Name:
Irinotecan (hydrochloride trihydrate)
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CAS No.:
136572-09-3
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Appearances: Light yellow to yellow Solid |
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Synonyms: (S)-[1,4'-Bipiperidine]-1'-... |
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Brief introduction:
Irinotecan Hcl-trihydrate prevents DNA from unwinding by inhibition of topoisomerase 1.
IC50 Value: 15.8 μM(LoVo cells); 5.17 μM(HT-29 cells)
Target: Topoisomerase I
in vitro: Irinotecan is activated to SN-38 by carboxylesterases to become able to interact with its target, topoisomerase I.
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Chemical Name:
(±)Campathecin
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CAS No.:
31456-25-4
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Purity: |
Appearances: Light yellow to yellow solid |
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Synonyms: (±)-Camptothecine;20(RS)-Ca... |
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Chemical Name:
Genistein
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CAS No.:
446-72-0
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: 4',5,7-Trihydroxyisoflavone... |
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Brief introduction:
Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
IC50 Value:
It has been shown that genistein inhibits many type of cancers including prostat...
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Chemical Name:
Levosimendan
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CAS No.:
141505-33-1
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Appearances: Light yellow to yellow Solid |
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Synonyms: OR1259;Simdax;OR-1259;OR 12... |
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Brief introduction:
Levosimendan(OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
Target: Others
Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
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Chemical Name:
Chenodeoxycholic Acid
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CAS No.:
474-25-9
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Appearances: White to off-white Solid |
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Synonyms: 3alpha,7alpha-Dihydroxy-5be... |
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Brief introduction:
Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.
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Chemical Name:
Sodium cholate
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CAS No.:
361-09-1
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Synonyms: Cholic acid sodium salt; So... |
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Chemical Name:
3-Phenyl-4H-chromen-4-one
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CAS No.:
574-12-9
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Chemical Name:
3-Benzoylacrylic acid
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CAS No.:
583-06-2
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Synonyms: 4-Oxo-4-phenyl-2-butenoic a... |
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Chemical Name:
4,5-Dichloro-3(2H)-pyridazinone
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CAS No.:
932-22-9
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Synonyms: 4,5-Dichloro-3-pyridazinol;... |
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