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Chemical Name:
Polaprezinc
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CAS No.:
107667-60-7
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Synonyms: Polaprezinc; Z 103. |
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Brief introduction:
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
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Chemical Name:
Zofenopril (calcium)
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CAS No.:
81938-43-4
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: SQ26991;Zoprace; |
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Brief introduction:
Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.
Target: ACE
Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1].
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Chemical Name:
Fasudil
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CAS No.:
103745-39-7
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Appearances: white |
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Synonyms: AT-877;HA-1077;AT877;HA1077... |
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Brief introduction:
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
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Chemical Name:
Lornoxicam
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CAS No.:
70374-39-9
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: Chlortenoxicam;Xefo;Ro 13-9... |
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Brief introduction:
Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).
Target: COX
Lornoxicam showed a balanced inhibition of COX-1/-2 exhibiting the lowest IC50 (0.005 microM/0.008 microM) of the large panel of NSAIDs tested.
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Chemical Name:
Parecoxib (Sodium)
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CAS No.:
198470-85-8
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Dynastat;Rayzon;SC 69124A; ... |
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Brief introduction:
Parecoxib is a potent and selective COX-2 inhibitor.
IC50 value:
Target: COX-2
in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].
in vivo: Adult male Sprague-Dawley rats were administered pa...
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Chemical Name:
Rocuronium (Bromide)
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CAS No.:
119302-91-9
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Appearances: White to off-white Solid |
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Synonyms: [3-Hydroxy-10,13-dimethyl-2... |
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Brief introduction:
Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.
IC50 Value:
in vitro: Rocuronium reduced the indirectly elicited twitch tensions in normal...
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Chemical Name:
Iloperidone
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CAS No.:
133454-47-4
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 1-[4-[3-[4-(6-Fluoro-1,2-be... |
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Brief introduction:
Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
IC50 value:
Target: 5-HT receptor; D2 receptor
Iloperidone (HP 873) is a compound currently in clinical trials for the treatment of schizophrenia.
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Chemical Name:
Tofacitinib (citrate)
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CAS No.:
540737-29-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Tasocitinib citrate;CP-6905... |
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Brief introduction:
Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.
IC50 value: 1 nM [1]
Target: JAK3
in vitro: CP-690550 is a specific, orally inhibitor of JAK3, it is 20- to 100-fold less potent for JAK2 and JAK1 with IC50 of 20 nM and 112 nM, respectively.
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Chemical Name:
Pramipexole (dihydrochloride)
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CAS No.:
104632-25-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: (S)-N6-propyl-4,5,6,7-tetra... |
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Brief introduction:
Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
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Chemical Name:
Agomelatine
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CAS No.:
138112-76-2
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: N-(2-(7-Methoxynaphth-1-yl)... |
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Brief introduction:
Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).
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Chemical Name:
Linezolid
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CAS No.:
165800-03-3
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Purity: |
Appearances: White to off-white solid |
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Synonyms: (S)-N-[[3-(3-Fluoro-4-morph... |
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Brief introduction:
Linezolid(Zyvoxid) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.
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Chemical Name:
Granisetron (Hydrochloride)
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CAS No.:
107007-99-8
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: BRL 43694A;Kytril; 1-methyl... |
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Brief introduction:
Granisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]
Target: 5-HT3 receptor
in vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM.
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