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ChemieTek

17

Basic Information

Company Name:ChemieTek

Business Type:Chemical manufacturer

Total NO.Employees:

Country/Region:USA

Certificates:

Year Established:

Introduction of ChemieTek

WELCOME TO CHEMIETEK ChemieTek is a chemistry company. Our company's specialties encompass the following: Custom synthesis and contract research in the fields of organic and medicinal chemistry. Manufacture and sale of chemical and biochemical products. Research and development of chemical entities of medicinal use Based in Indianapolis, Indiana - the crossroads of America - ChemieTek's expert staff is headed by Dr. W. Willie Yuan, who has spent more than ten years of product research and development in the pharmaceutical and biotech industry in the United States.

Web: www.chemietek.com TEL:+1 (317) 598-0828 Fax:+1 (317) 598-0835 Email:[email protected]

Products of ChemieTek

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Brief introduction:

    Defactinib is a novel <b>FAK</b> inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

  • Chemical Name: Palbociclib (isethionate)
    CAS No.: 827022-33-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PD0332991 isethionate;PD-03... Quality Control & MSDS Files:
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    Brief introduction:

    Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

  • Chemical Name: PF-06463922
    CAS No.: 1454846-35-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PF 06463922;PF 06463922; Quality Control & MSDS Files:
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    Brief introduction:

    PF-06463922 is a potent, dual <b>ALK/ROS1</b> inhibitor, with <b>K<sub>i</sub></b> of < 0.02 nM, < 0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

  • Chemical Name: GSK2141795
    CAS No.: 1047634-65-0 Purity: Appearances: White to off-white solid
    Brand: Synonyms: GSK 2141795;GSK-2141795; N-... Quality Control & MSDS Files:
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    Brief introduction:

    GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1). IC50 value: 180/328/38 nM (Akt1/2/3) Target: pan-Akt inhibitor KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with lit...

  • Chemical Name: Eprosartan (mesylate)
    CAS No.: 144143-96-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-[[2-Butyl-5-(2-carboxy-3-... Quality Control & MSDS Files:
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    Brief introduction:

    Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively.

  • Chemical Name: NMS-1286937
    CAS No.: 1034616-18-6 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: NMS-P937;NMS1286937;NMS 128... Quality Control & MSDS Files:
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    Brief introduction:

    NMS-1286937(NMS-P937) is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor(IC50=2 nM) with potential antineoplastic activity; no inhibition on PLK2 and PLK3. IC50 value: 2 nM [1] Target: PLK1 in vitro: NMS-P937 potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibit...

  • Chemical Name: LEE011
    CAS No.: 1211441-98-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: LEE 011;LEE-011; 7-cyclopen... Quality Control & MSDS Files:
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    Brief introduction:

    LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

  • Chemical Name: AZD-9291
    CAS No.: 1421373-65-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: EGFR inhibitor;AZD9291;AZD ... Quality Control & MSDS Files:
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    Brief introduction:

    AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).

  • Chemical Name: GSK1324726A
    CAS No.: 1300031-52-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: I-BET726;GSK 1324726A;GSK-1... Quality Control & MSDS Files:
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    Brief introduction:

    GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM). IC50 Value: 41 nM (BRD2); 31 nM (BRD3); 22 nM (BRD4) [1] Target: BET protein in vitro: I-BET726 is a novel small molecule inhibitor that binds to the...

  • Chemical Name: MS436
    CAS No.: 1395084-25-9 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: MS-436;MS 436; (E)-4-((2-am... Quality Control & MSDS Files:
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    Brief introduction:

    MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM. IC50 Value: 30-50 nM (Ki) [1] Target: BRD4 bromodomain MS436 exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference for the first bromodomain over the second.

  • Chemical Name: TAK-632
    CAS No.: 1228591-30-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: TAK 632;TAK632; N-(7-cyano-... Quality Control & MSDS Files:
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    Brief introduction:

    TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; > 60 fold selectivity over VEGFR. IC50 Value: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR) [1] Target: B-Raf; C-Raf In vitro: TAK-632 inhibited phosphorylation of MEK (pMEK) in melanoma A375 cells (BRAFV600E) with an IC50 valu...

  • Chemical Name: Debio 0932
    CAS No.: 1061318-81-7 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Debio 0932 ,CUDC-305; 2-((6... Quality Control & MSDS Files:
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    Brief introduction:

    Debio 0932 is an orally active <b>HSP90</b> inhibitor, with <b>IC<sub>50</sub></b>s of 100 and 103 nM for HSP90α and HSP90β, respectively.

  • Chemical Name: AZD5363
    CAS No.: 1143532-39-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AZD-5363;AZD 5363; (S)-4-am... Quality Control & MSDS Files:
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    Brief introduction:

    AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM). IC50 Value: <10 nM(Akt1/2/3) Target: pan-Akt AZD5363 has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent, and has potential for personalized medicine based on the genetic status of PIK3CA, ...

  • Chemical Name: Ruxolitinib
    CAS No.: 941678-49-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: INCB 018424;INCB018424;INCB... Quality Control & MSDS Files:
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    Brief introduction:

    Ruxolitinib(INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

  • Chemical Name: Motesanib (Diphosphate)
    CAS No.: 857876-30-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AMG-706; Motesanib;AMG706; ... Quality Control & MSDS Files:
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    Brief introduction:

    Motesanib diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. IC50 value: 2 nM/3 nM/6 nM/8 nM(VEGFR1/2/3/c-Kit) [1] Target: pan-VEGFR; Kit in vitro: Motesanib Diphosphate has broad act...

  • Chemical Name: Alisertib
    CAS No.: 1028486-01-2 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: MLN 8237;MLN8237;MLN-8237; ... Quality Control & MSDS Files:
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    Brief introduction:

    Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM; has >200-fold higher selectivity for Aurora A than Aurora B. IC50 Value: 1.2 nM (Aurora A) Target: Aurora A in vitro: MLN8237 (0.5 μM) treatment inhibits the phosphorylation of Aurora A in MM1.S and OPM1 cells, without affecting the Aurora B mediated histone ...