Chem-Cook Chemicals Ltd.

Ropinirole hydrochloride(SKF101468 hydrochloride) a selective dopamine D2 receptor inhibitor with IC50 of 29 nM. Target: Dopamine D2 Receptor Ropinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice.

Formestane(CGP-32349; 4-OHA) is a selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer. Target: Aromatase Formestane (Lentaron) is a type I, steroidal aromatase inhibitor.

Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent; as a reducing or "deprotecting" agent for thiolated DNA.

Methylcobalamin a cobalamin, is a form of vitamin B12. Target: Others Methylcobalamin is a cobalamin, a form of vitamin B12.

Carbazochrome(AC-17) is an antihemorrhagic agent. Target: Others Carbazochrome is an antihemorrhagic agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.

Modafinil(CRL 40476, CEP 1538) is a central nervous system vigilance promoting agent, which posseses neuroprotective properties. IC50 value: Target: in vitro: Modafinil was found to inhibit K(Ca)3.1 currents in a concentration-dependent manner, and the half-maximal inhibition (IC(50)) of modafinil for the current inhibition was 6.8...

Telmisartan(BIBR 277) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. IC50 Value: 9.2 nM [1] Target: Angiotensin Receptor in vitro: In intact RVSMC cells and in membrane preparations, telmisartan inhibits the binding of 125I-AngII to AT1 receptors in a concentratio...

Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid. Target: Proton Pump Lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been studied in healthy adults given oral lansoprazole 30 mg once daily for 11 days.

Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi) [1] Target: M3 receptor in vitro: Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced concentration-dependent contract...

Temozolomide, an alkylating agent, is a DNA damage inducer. IC50 Value: Target: DNA alkylator Temozolomide is a DNA methylating, chemotherapeutic agent.

Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).

Rifaximin(Xifaxan) is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. IC50 Value: Target: RNA polymerase; antibacterial Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that very little of the drug will pass the gastrointestinal wall ...

Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. IC50 Value: N/A Target: DNA/RNA Synthesis in vitro: Fludarabine Phosphate is converted to F-ara-ATP in cells and then incorporated into DNA in a self-limiting manner.