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Carbosynth Limited

594

Basic Information

Company Name:Carbosynth Limited

Business Type:Chemical manufacturer

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Introduction of Carbosynth Limited

Carbosynth offers over 4500 carbohydrates and nucleosides. This range includes monosaccharides, enzyme substrates, D- and L- sugars, oligosaccharides, detergents and nucleosides. Our catalogue offers quantities for R&D, but many are produced in bulk. For example 2-deoxy-D-glucose, IPTG, methyl-a-D-glucopyranoside, n-octyl-b-D-glucopyranoside, 3,4,6-Tri-O-acetyl-D-galactal, gulonic acid-gamma-lactone, diacetone-D-mannose and 2-nitrophenyl-b-D-galactopyranoside are produced in 10’s-1000’s of kilos. Carbosynth Carbohdrates ProductsCarbosynth Nucleosides ProductsCarbosynth Fine Chemicals Products. At Carbosynth we also offer a range of allied fine chemicals. Many of which are versatile building blocks or have specialist applications ranging from biochemical reagents to natural antioxidants. Included in this product range are coupling agents, such as EDAC, or activators in peptide and oligonucleotide synthesis. Custom synthesis is one of Carbosynths fastest growing business sectors. We are

Web: www.carbosynth.com TEL:+44 (1635) 578-444 Fax:+44 (1635) 579-444 Email:[email protected]

Products of Carbosynth Limited

  • Chemical Name: SB-505124
    CAS No.: 694433-59-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SB 505124;SB505124; 2-(4-(b... Quality Control & MSDS Files:
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    Brief introduction:

    SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. IC50 Value: 47 ± 5 nM (ALK5); 129 ± 11 nM (ALK4) [1] Target: ALK4/5 in vitro: SB-505124 was identified as a potent inhibitor of the in vitro kinase activity of ALK5 for its...

  • Chemical Name: Nocodazole
    CAS No.: 31430-18-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Oncodazole;R17934; methyl (... Quality Control & MSDS Files:
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    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. IC50 value: 0.21 uM (Abl) [1] Target: microtubule; Abl in vitro: Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphory...

  • Chemical Name: TRAM-34
    CAS No.: 289905-88-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: TRAM34;TRAM 34; 1-((2-chlor... Quality Control & MSDS Files:
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    TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM).

  • Chemical Name: Camostat (mesylate)
    CAS No.: 59721-29-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Camostat mesilate;FOY305;FO... Quality Control & MSDS Files:
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    Camostat Mesylate(FOY305; FOY-S980) is a trypsin-like protease inhibitor Target: Trypsin-like protease Camostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs [1].

  • Chemical Name: M344
    CAS No.: 251456-60-7 Purity: Appearances: White to off-white solid
    Brand: Synonyms: M 344;M-344;D 237;MS 344; 4... Quality Control & MSDS Files:
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    M344 is a potent HDAC inhibitor, which can also induced expression of the pro-apoptotic genes, Puma and Bax, together with the morphological features of apoptosis, in MCF-7 cells.

  • Chemical Name: Mitoxantrone
    CAS No.: 65271-80-9 Purity: Appearances:
    Brand: Synonyms: 1,4-Dihydroxy-5,8-bis[2-(2-... Quality Control & MSDS Files:
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    Mitoxantrone, a type II topoisomerase inhibitor, is an anthracenedione-derived antineoplastic agent. Target: Topoisomerase II Mitoxantrone is an anthracenedione antineoplastic agent.

  • Chemical Name: Limonin
    CAS No.: 1180-71-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Limonoate D-ring-lactone; L... Quality Control & MSDS Files:
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    Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability. IC50 Value: Target: HIV; anticancer Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits.

  • Chemical Name: Iloperidone
    CAS No.: 133454-47-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 1-[4-[3-[4-(6-Fluoro-1,2-be... Quality Control & MSDS Files:
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    Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms. IC50 value: Target: 5-HT receptor; D2 receptor Iloperidone (HP 873) is a compound currently in clinical trials for the treatment of schizophrenia.

  • Chemical Name: Aconitine
    CAS No.: 302-27-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Acetylbenzoylaconine; (3R,4... Quality Control & MSDS Files:
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    Aconitine is a C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.

  • Chemical Name: Daidzin
    CAS No.: 552-66-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 7-(-D-Glucopyranosyloxy)-3-... Quality Control & MSDS Files:
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    Daidzin, a natural organic compound in the class of phytochemicals known as isoflavones, is a potent and selective inhibitor of <b>human mitochondrial aldehyde dehydrogenase</b> and inhibits ALDH-I selectively (Ki=20 nM); at least 500 times less effective against ALDH-Ⅱ, the cytosolic isozyme (Ki=10 μM).

  • Chemical Name: Bergenin
    CAS No.: 477-90-7 Purity: Appearances:
    Brand: Synonyms: Cuscutin Quality Control & MSDS Files:
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    Bergenin alias Cuscutin is trihydroxybenzoic acid glycoside. It is the C-glycoside of 4-O-methyl gallic acid. It possesses an O-demethylated derivative called norbergenin. These are chemical compounds and drugs of Ayurveda, commonly known as Paashaanbhed. It shows a potent immunomodulatory effect. Bergenin can be isolated from Bergenia...

  • Chemical Name: Glycitein
    CAS No.: 40957-83-3 Purity: Appearances:
    Brand: Synonyms: 4',7-Dihydroxy-6-methoxyiso... Quality Control & MSDS Files:
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    Brief introduction:

    Glycitein is found in soy and red clover. It exhibits a variety of biological activities, including increasing Nrf2-related antioxidative signaling, preventing invasion in glioma cells destabilizing amyloid-β aggregates and preventing fibril assembly, and inhibiting osteoclast generation.

  • Chemical Name: Glycitin
    CAS No.: 40246-10-4 Purity: Appearances:
    Brand: Synonyms: 3-(4-Hydroxyphenyl)-6-metho... Quality Control & MSDS Files:
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    Brief introduction:

    Glycitin, a natural isoflavone isolated from legumes, has antibacterial, antiviral and estrogenic activities and may exerts preventative effects on alcoholism, cardiovascular and cerebrovascular diseases and some types of cancer.

  • Chemical Name: Podophyllotoxin
    CAS No.: 518-28-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Podophyllinic acid lactone;... Quality Control & MSDS Files:
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    Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II. IC50 Value: Target: Topoisomerase II; Microtubule/Tubulin Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells.

  • Chemical Name: Cortodoxone
    CAS No.: 152-58-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 11-Deoxycortisol;cortexolon... Quality Control & MSDS Files:
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    Brief introduction:

    Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone); exhibits corticosteroid binding characteristics, including DNA binding; 11-deoxycortisol is regulated by the hypothalamus-pituitary axis and responded to acute stress; impedes GABAergic neurotransmission and induces drug-resistant statu...

  • Chemical Name: Naphthalene, 1-isocyanato-
    CAS No.: 86-84-0 Purity: Appearances:
    Brand: Synonyms: 1-Isocyanatonaphthalene; al... Quality Control & MSDS Files:
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  • Chemical Name: Nisoldipine
    CAS No.: 63675-72-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 1,4-Dihydro-2,6-dimethyl-4-... Quality Control & MSDS Files:
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    Brief introduction:

    Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

  • Chemical Name: Retigabine (dihydrochloride)
    CAS No.: 150812-13-8 Purity: Appearances: White to off-white solid
    Brand: Synonyms: N-(2-Amino-4-(4-fluorobenzy... Quality Control & MSDS Files:
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    Brief introduction:

    Retigabine 2Hcl (Ezogabine; D23129) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. IC50 value: Target: Kv7.2-7.5 Retigabine (D-23129) is a novel antiepileptic compound with broad spectrum and potent anticonvulsant properties, both in vitro and in vivo.

  • Chemical Name: Tegafur
    CAS No.: 17902-23-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 5-Fluoro-1-(tetrahydro-2-fu... Quality Control & MSDS Files:
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    Brief introduction:

    Tegafur (also known as Ftorafur) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.

  • Chemical Name: Racecadotril
    CAS No.: 81110-73-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Acetorphan; benzyl 2-(3-(ac... Quality Control & MSDS Files:
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    Brief introduction:

    Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation.

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