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Carbosynth Limited

594

Basic Information

Company Name:Carbosynth Limited

Business Type:Chemical manufacturer

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Introduction of Carbosynth Limited

Carbosynth offers over 4500 carbohydrates and nucleosides. This range includes monosaccharides, enzyme substrates, D- and L- sugars, oligosaccharides, detergents and nucleosides. Our catalogue offers quantities for R&D, but many are produced in bulk. For example 2-deoxy-D-glucose, IPTG, methyl-a-D-glucopyranoside, n-octyl-b-D-glucopyranoside, 3,4,6-Tri-O-acetyl-D-galactal, gulonic acid-gamma-lactone, diacetone-D-mannose and 2-nitrophenyl-b-D-galactopyranoside are produced in 10’s-1000’s of kilos. Carbosynth Carbohdrates ProductsCarbosynth Nucleosides ProductsCarbosynth Fine Chemicals Products. At Carbosynth we also offer a range of allied fine chemicals. Many of which are versatile building blocks or have specialist applications ranging from biochemical reagents to natural antioxidants. Included in this product range are coupling agents, such as EDAC, or activators in peptide and oligonucleotide synthesis. Custom synthesis is one of Carbosynths fastest growing business sectors. We are

Web: www.carbosynth.com TEL:+44 (1635) 578-444 Fax:+44 (1635) 579-444 Email:[email protected]

Products of Carbosynth Limited

  • Chemical Name: Pimecrolimus
    CAS No.: 137071-32-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: ASM 981 Quality Control & MSDS Files:
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    Brief introduction:

    Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12. Target: Others Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function [1].

  • Chemical Name: Pemetrexed (disodium)
    CAS No.: 150399-23-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N-[4-[2-(2-amino-4,7-dihydr... Quality Control & MSDS Files:
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    Brief introduction:

    Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. IC50 Value: 1.3nM(Ki for TS); 7.2nM(DHFR); 65nM(GARFT) Target: Antifolate in vitro: The Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibition against TS, DHFR, and GARFT,...

  • Chemical Name: Oleandrin
    CAS No.: 465-16-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Corrigen; Foliandrin; Folin... Quality Control & MSDS Files:
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    Brief introduction:

    Oleandrin, also known as PBI-05204 , is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and ...

  • Chemical Name: Noscapine
    CAS No.: 128-62-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Noscapine; (S)-6,7-dimethox... Quality Control & MSDS Files:
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    Brief introduction:

    Noscapine is a naturally occurring opium alkaloid that is a centrally acting antitussive agent. Noscapine is discontinued.

  • Chemical Name: Mometasone furoate
    CAS No.: 83919-23-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 9-Chloro-17-(2-chloroacetyl... Quality Control & MSDS Files:
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    Brief introduction:

    Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. IC50 value: Target: glucocorticosteroid receptor Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma [1].

  • Chemical Name: PJ34 (hydrochloride)
    CAS No.: 344458-15-7 Purity: Appearances: White to gray Solid
    Brand: Synonyms: PJ-34 hydrochloride;PJ 34 h... Quality Control & MSDS Files:
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    Brief introduction:

    PJ34 hydrochloride is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.

  • Chemical Name: Bosentan (hydrate)
    CAS No.: 157212-55-0 Purity: Appearances: White to off-white solid
    Brand: Synonyms: 4-(1,1-Dimethylethyl)-N-(6-... Quality Control & MSDS Files:
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    Brief introduction:

    Bosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. IC50 value: Target: ETA/ETB receptor Under normal conditions, endothelin-1 binding of ET-A or ET-B receptors causes constriction of the pulmonary blood vessels.

  • Chemical Name: Guanfacine (hydrochloride)
    CAS No.: 29110-48-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Guanfacine;Tenex;Intuniv; N... Quality Control & MSDS Files:
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    Brief introduction:

    Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.

  • Chemical Name: Miltefosine
    CAS No.: 58066-85-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: HePC;Impavido;Miltex;Hexade... Quality Control & MSDS Files:
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    Brief introduction:

    Miltefosine is an alkylphosphocholine drug. Target: Antiparasitic Miltefosine is an alkylphosphocholine drug with demonstrated activity against various parasite species and cancer cells as well as some pathogenic bacteria and fungi.

  • Chemical Name: Mifepristone
    CAS No.: 84371-65-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 11b-[p-(Dimethylamino)pheny... Quality Control & MSDS Files:
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    Brief introduction:

    Mifepristone(RU-38486; RU486) is a progesterone receptor antagonist(IC50= 0.2 nM) used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. IC50 Value: 0.2 nM (Progesterone receptor); 2.6 nM (Glucocorticoid receptor) [1] Target: Progesterone receptor Mifepristone is a synthetic st...

  • Chemical Name: Meropenem
    CAS No.: 96036-03-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Quality Control & MSDS Files:
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  • Chemical Name: 6-Mercaptopurine
    CAS No.: 50-44-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 1,7-Dihydro-6H-purine-6-thi... Quality Control & MSDS Files:
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    Brief introduction:

    Mercaptopurine (6-mercaptopurine; 6-MP) is an immunosuppressive drug; is a thiopurine. IC50 Value: 149.5±124.9 nM (PBMC blastogenesis) [1] Target: Nucleoside antimetabolite in vitro: Both AZ and 6-MP dose-dependently suppressed PBMC blastogenesis.

  • Chemical Name: Megestrol (Acetate)
    CAS No.: 595-33-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 17alpha-Acetoxy-6-methylpre... Quality Control & MSDS Files:
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    Brief introduction:

    Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2. Target: Progesterone Receptor Megestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylat...

  • Chemical Name: Levoleucovorin (Calcium)
    CAS No.: 80433-71-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: Calcium levofolinate;Elvori... Quality Control & MSDS Files:
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    Brief introduction:

    Levoleucovorin calcium is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid. IC50 value: Target: Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

  • Chemical Name: Levamisole (hydrochloride)
    CAS No.: 16595-80-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (-)-Tetramisole hydrochlori... Quality Control & MSDS Files:
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    Brief introduction:

    Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis.

  • Chemical Name: Leuprolide (Acetate)
    CAS No.: 74381-53-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Leuprorelin acetate;Lupron;... Quality Control & MSDS Files:
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    Brief introduction:

    Leuprolide acetate (Leuprorelin) is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors. IC50 Value: Target: GnRH receptor By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) a...

  • Chemical Name: (-)-Epigallocatechin Gallate
    CAS No.: 989-51-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (2R,3R)-2-(3,4,5-Trihydroxy... Quality Control & MSDS Files:
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    Brief introduction:

    Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase.

  • Chemical Name: RG108
    CAS No.: 48208-26-0 Purity: Appearances: light yellow to green yellow solid
    Brand: Synonyms: (S)-3-(Indol-3-yl)-2-(1,3-d... Quality Control & MSDS Files:
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    Brief introduction:

    RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM. IC50 Value: 115 nM Target: DNMT in vitro: RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines.

  • Chemical Name: Ganciclovir
    CAS No.: 82410-32-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-Amino-1,9-dihydro-9-((2-h... Quality Control & MSDS Files:
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    Brief introduction:

    Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. IC50 value: 5.2 uM [1] Target: feline herpesvirus type-1 (FHV-1) in vitro: In vitro efficacy of idoxuridine and ganciclovir against FHV-1 was approximately equivalent and about twice that of cidofovir and penciclovir [1].

  • Chemical Name: Fulvestrant
    CAS No.: 129453-61-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (7a,17b)-7-[9-[(4,4,5,5,5-P... Quality Control & MSDS Files:
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    Brief introduction:

    Fulvestrant(ZM 182780; ICI 182780 ) is a representative pure antiestrogen and a Selective Estrogen Receptor Down-regulator (SERD). IC50 Value: 94 uM Target: Estrogen Receptor In contrast to the Selective Estrogen Receptor Modulators (SERMs) such as 4-hydroxytamoxifen that bind to estrogen receptor α (ERα) as antagonists or partial a...

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