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Biochem Tek(Shanghai) Co., ltd.

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Basic Information

Company Name:Biochem Tek(Shanghai) Co., ltd.

Business Type:Chemical manufacturer

Total NO.Employees:

Country/Region:China

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Year Established:

Introduction of Biochem Tek(Shanghai) Co., ltd.

Web: www.biochemtek.com TEL:+86 (21) 5199-1287 Fax: Email:[email protected]

Products of Biochem Tek(Shanghai) Co., ltd.

  • Chemical Name: Harpagoside
    CAS No.: 19210-12-9 Purity: Appearances:
    Brand: Synonyms: [(1S,4aS,5R,7S,7aS)-4a,5-Di... Quality Control & MSDS Files:
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    Brief introduction:

    Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (DevilÂ’s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degra...

  • Chemical Name: (+)-Bicuculline
    CAS No.: 485-49-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (R-(R*,S*))-6-(5,6,7,8-Tetr... Quality Control & MSDS Files:
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    Brief introduction:

    (+)-Bicuculline is a competitive antagonist of <b>GABA<sub>A</sub></b> receptors with <b>IC50</b> of 2 μM, also blocks Ca(2+)-activated potassium channels.

  • Chemical Name: Teniposide
    CAS No.: 29767-20-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Vumon;VM-26;VM26;VM 26; (5R... Quality Control & MSDS Files:
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    Brief introduction:

    Teniposide(VM-26) is a semisynthetic derivative of podophyllotoxin and are increasingly used in cancer medicine; causing breaks in DNA via an interaction with DNA topoisomerase II. IC50 value: Target: Topo II Teniposide is a phase-specific cytotoxic drug acting in the late S and early G2 phases of the cell cycle.

  • Chemical Name: Valspodar
    CAS No.: 121584-18-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Cyclo[[(2S,4R,6E)-4-methyl-... Quality Control & MSDS Files:
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    Brief introduction:

    Valspodar(PSC833) is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR).

  • Chemical Name: Varespladib
    CAS No.: 172732-68-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: [[3-(Aminooxoacetyl)-2-ethy... Quality Control & MSDS Files:
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    Brief introduction:

    LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM. IC50 value: 7 nM Target: sPLA2 in vitro: LY315920 exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50 of 8.1...

  • Chemical Name: LY404039
    CAS No.: 635318-11-5 Purity: Appearances: White to gray solid
    Brand: Synonyms: LY 404039;LY-404039; (1R,4S... Quality Control & MSDS Files:
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    Brief introduction:

    LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor. IC50 Value:149 nM(Ki for mGlu2); 92 nM(Ki for mGlu3)[1] Target: mGluR1; mGluR2 Metabotropic glutamate (mGlu) receptors have been shown to mediate a number of behaviors including emotionality and responsivity to stress as d...

  • Chemical Name: Dalcetrapib
    CAS No.: 211513-37-0 Purity: Appearances: White to off-white solid
    Brand: Synonyms: JTT-705;RO-4607381;JTT705;J... Quality Control & MSDS Files:
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    Brief introduction:

    Dalcetrapib (JTT-705; RO-4607381) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol.

  • Chemical Name: Dapagliflozin
    CAS No.: 461432-26-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: BMS-512148;BMS512148;BMS 51... Quality Control & MSDS Files:
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    Brief introduction:

    Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).

  • Chemical Name: Saquinavir (Mesylate)
    CAS No.: 149845-06-7 Purity: Appearances: White to off-white solid
    Brand: Synonyms: (S)-N1-((2S,3R)-4-((3S,4aS,... Quality Control & MSDS Files:
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    Brief introduction:

    Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

  • Chemical Name: Entinostat
    CAS No.: 209783-80-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: MS-275; SNDX-275; MS 275; S... Quality Control & MSDS Files:
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    Brief introduction:

    Entinostat (MS-275; SNDX 275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM. IC50 Value: 0.51 μM(HDAC1); 1.7 μM(HDAC3) Target: HDAC1/3 in vitro: MS-275 shows inhibitory to HDACs by 2'-amino group.

  • Chemical Name: XAV-939
    CAS No.: 284028-89-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: XAV939; NVP-XAV 939; 2-(4-(... Quality Control & MSDS Files:
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    Brief introduction:

    XAV939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively. IC50 Value: 11 nM(TNKS1); 4 nM(TNKS2) Target: TMKS1/2; β-catenin in vitro: XAV-939 specifically inhibits tankyr...

  • Chemical Name: Semagacestat
    CAS No.: 425386-60-3 Purity: Appearances: White to off-white solid
    Brand: Synonyms: LY450139;LY-450139;LY 45013... Quality Control & MSDS Files:
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    Brief introduction:

    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. IC50 value: 10.9/12.1/12.0 nM (Aβ42/Aβ40/Aβ38); 14.1 nM (Notch signaling) [1] in vitro: Semagacestat reduces the secretion of Aβ42, Aβ40 and Aβ38 from H4 human glioma ...

  • Chemical Name: Vismodegib
    CAS No.: 879085-55-9 Purity: Appearances: White to off-white solid
    Brand: Synonyms: GDC-0449;GDC 0449;GDC0449; ... Quality Control & MSDS Files:
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    Brief introduction:

    Vismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM. IC50 value: 3 nM (hedgehog); 3.0 uM (P-gp) [1] Target: hedgehog in vitro: GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cel...

  • Chemical Name: GDC-0879
    CAS No.: 905281-76-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GDC0879;GDC 0879; (E)-5-(1-... Quality Control & MSDS Files:
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    Brief introduction:

    GDC-0879 is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well; no inhibition known to other protein kinases. IC50 value: 0.13 nM [1] Target: B-Raf in vitro: GDC-0879 also inhibits cellular pERK with IC50 of 63 nM.

  • Chemical Name: Abiraterone
    CAS No.: 154229-19-3 Purity: Appearances: White to off-white solid
    Brand: Synonyms: 17-(3-Pyridyl)androsta-5,16... Quality Control & MSDS Files:
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    Brief introduction:

    Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM.

  • Chemical Name: TW-37
    CAS No.: 877877-35-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: TW 37;TW37; N-(4-((2-(tert-... Quality Control & MSDS Files:
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    Brief introduction:

    TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. IC50 Value: 0.29 μM (Ki for Bcl-2) Target: Bcl-2 Family in vitro: TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primar...

  • Chemical Name: Vatalanib (dihydrochloride)
    CAS No.: 212141-51-0 Purity: Appearances: Off-white to pink Solid
    Brand: Synonyms: PTK787 dihydrochloride;PTK/... Quality Control & MSDS Files:
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    Brief introduction:

    Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of <b>VEGFR2/KDR</b> with <b>IC<sub>50</sub></b> of 37 nM.

  • Chemical Name: BEZ235
    CAS No.: 915019-65-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: NVP-BEZ 235;BEZ-235;BEZ 235... Quality Control & MSDS Files:
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    Brief introduction:

    BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM/5 nM/7 nM/75 nM/6 nM, respectively; inhibits ATR with IC50 of 21 nM; shown to be poor inhibitory to Akt and PDK1. IC50 value: 4 nM/5 nM/7 nM/75 nM/6 nM(p110α/γ/δ/β/mTOR) [1] Target: PI3K/mTOR in vitro: BEZ235 sign...

  • Chemical Name: Motesanib
    CAS No.: 453562-69-1 Purity: Appearances: White to off-white solid
    Brand: Synonyms: AMG 706; AMG-706; N-(3,3-di... Quality Control & MSDS Files:
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    Brief introduction:

    Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. IC50 value: 2 nM/3 nM/6 nM/8 nM(VEGFR1/2/3/c-Kit) [1] Target: pan-VEGFR; Kit in vitro: Motesanib Diphosphate has broad activity agains...

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