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Chemical Name:
IM-12
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CAS No.:
1129669-05-1
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: IM 12;IM12; 3-((4-fluorophe... |
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Brief introduction:
IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC<sub>50</sub></b> of 53 nM, and also enhances Wnt signalling.
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Chemical Name:
(R)-(-)-Rolipram
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CAS No.:
85416-75-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: (R)-Rolipram;(-)-Rolipram; ... |
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Brief introduction:
(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.
IC50 value:
Target: PDE4
in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 ...
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Chemical Name:
MI 2
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CAS No.:
1047953-91-2
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: MALT1 inhibitor |
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Brief introduction:
MI 2 (MALT1 inhibitor) is an irreversible <b>MALT1</b> protease inhibitor with an <b>IC<sub>50</sub></b> of 5.84 μM.
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Chemical Name:
AK-7
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CAS No.:
420831-40-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: AK 7;AK7; 3-(azepan-1-ylsul... |
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Brief introduction:
AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models.
IC50 value:
Target: SIRT2
AK-7 treated R6/2 mice performed significantly better than vehicle treated littermates on the accelerating rotarod at 8 and 11 weeks of age.
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Chemical Name:
FR 180204
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CAS No.:
865362-74-9
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: FR 180204;FR-180204; 5-(2-p... |
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Brief introduction:
FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
IC50 value: 0.31 uM/0.14 uM(Ki for ERK1/ERK2); 0.51uM/0.33 μM(ERK1/ERK2) [1] [2]
Target: ERK1/2 inhibitor
in vi...
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Chemical Name:
iCRT 14
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CAS No.:
677331-12-3
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: iCRT14;iCRT-14; (Z)-5-((2,5... |
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Brief introduction:
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).
IC50 value: 40.3 nM [1]
Target: Wnt inhibitor
Thought to directly influence the interaction between β-catenin and TCF4.
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Chemical Name:
SJ-172550
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CAS No.:
431979-47-4
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Purity: |
Appearances: Pink to red Solid |
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Synonyms: SJ172550;SJ 172550; (E)-met... |
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Brief introduction:
SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
IC50 value: 0.84 uM(EC50) [1]
Target: MDMX inhibitor
in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX prot...
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Chemical Name:
Eluxadoline
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CAS No.:
864821-90-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: JNJ 27018966;JNJ27018966;JN... |
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Brief introduction:
Eluxadoline is a mixed <b>μ-</b> and <b>κ-opioid receptor</b> agonist and <b>δ-opioid receptor</b> antagonist.
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Chemical Name:
GW311616 (hydrochloride)
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CAS No.:
197890-44-1
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Purity: |
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Synonyms: GW-311616 hydrochloride;GW ... |
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Brief introduction:
GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM.
IC50 value: 22 nM [1]
Target: neutrophil elastase
The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin...
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Chemical Name:
Palbociclib (isethionate)
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CAS No.:
827022-33-3
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: PD0332991 isethionate;PD-03... |
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Brief introduction:
Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1]
Target: Cdk4/Cdk6
in vitro: ATP competitive inhibitor of Cdk4.
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Chemical Name:
CID755673
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CAS No.:
521937-07-5
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: CID 755673;CID-755673; 7-hy... |
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Brief introduction:
CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms.
IC50 value: 182 nM [1]
Target: PKD
in vitro: In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activatio...
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Chemical Name:
RTA-408
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CAS No.:
1474034-05-3
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Omaveloxolone |
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Brief introduction:
RTA-408 is an antioxidant inflammation modulator (AIM), which activates <b>Nrf2</b> and suppresses nitric oxide (NO).
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Chemical Name:
Difluprednate
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CAS No.:
23674-86-4
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: Durezol; (6S,8S,9R,10S,11S,... |
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Brief introduction:
Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain.
IC50 value:
Target:
Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a U.S.
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Chemical Name:
PS48
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CAS No.:
1180676-32-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: PS 48;PS-48; (Z)-5-(4-chlor... |
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Brief introduction:
PS48 is an activator of <b>PDK1</b> with an <b>AC<sub>50</sub></b> of 8 μM.
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Chemical Name:
AZD1981
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CAS No.:
802904-66-1
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: AZD 1981;AZD-1981; 2-(4-ace... |
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Brief introduction:
AZD1981 is a potent, selective <b>CRTh2 (DP2) receptor</b> antagonist with <b>IC50</b> of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.
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Chemical Name:
SB-334867 (free base)
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CAS No.:
792173-99-0
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: SB334867A free base;SB33486... |
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Brief introduction:
SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.
IC50 value: 7.2 (pKb) [1]
Target: orexin OX1 receptor
in vitro: SB-334867-A inhibited the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses (pK(B)=7.27+/-0.04 and 7.23+/-0.03 respectively, n=8), but had no effect on...
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Chemical Name:
DBeQ
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CAS No.:
177355-84-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: JRF 12;JRF12;JRF-12; N2,N4-... |
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Brief introduction:
DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
IC50 value: 1.5 uM
Target: p97
in vitro: DBeQ blocks UbG76V-GFP, ODD-Luc and Luc-ODC degradation with IC50 of 2.6 μM, 56 μM and 45 μM in HeLa cells.
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Chemical Name:
(R,R)-reboxetine (mesylate)
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CAS No.:
105017-39-8
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: |
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Brief introduction:
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Chemical Name:
DMOG
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CAS No.:
89464-63-1
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Purity: |
Appearances: Light yellow to yellow Oil |
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Synonyms: Dimethyloxallyl Glycine; me... |
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Brief introduction:
Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1α prolyl hydroxylase).
IC50 value:
Target: HIF-1α prolyl hydroxylase
The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-...
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Chemical Name:
C-7280948
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CAS No.:
587850-67-7
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: C 7280948 |
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Brief introduction:
C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM.
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