Ascent Scientific

Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin; potent TRPV1 receptor antagonist with 562 nM.

AM630 is a selectivity CB2 antagonist with Ki of 31.2 nM; > 150 fold selectivity over CB1 receptor. IC50 Value: 31.2 nM Target: CB2 receptor AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 uM and 31.2 nM, respectively.

SB203580(RWJ 64809) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 uM.

SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM); competes with ATP. IC50 value: 9 nM (Ki) Target: GSK-3α SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M).

Diazoxide is an ATP-sensitive <b>potassium channel</b> activator ; can be used to treat hyperinsulinism.

Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.

Pirenzepine dihydrochloride (LS519) is a selective <b>M1</b> muscarinic receptor antagonist.

Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).