Ark Pharm, Inc.

Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. IC50 value: 26 nM [1] Target: DPP4 in vitro: Saxagliptin has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than either vildagliptin or sitagliptin (another two DPP4 inhibitors) with...

(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. IC50 value: Target: PDE4 in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 ...

Oxybenzone(Eusolex 4360; Escalol 567) is an organic compound used in sunscreens; provides broad-spectrum ultraviolet coverage, including UVB and short-wave UVA rays.

Tolazoline(NSC35110; Imidaline) is a non-selective competitive α-adrenergic receptor antagonist. IC50 value: Target: α-adrenoceptor antagonist Tolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product.

γ-GT(63699-78-5) is a substrate for γ-glutamyl transferase in biochemical test.

DTE (Dithioerythritol) is a sulfur containing sugar derived from the corresponding 4-carbon monosaccharide erythrose; is an epimer of dithiothreitol(DTT).

CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU).

BCA is 2,2-Biquinoline-4,4-dicarboxylic acid disodium salt; Determination of Cu and protein assay.

ABTS diammonium salt is a chemical compound used to observe the reaction kinetics of specific enzymes; A common use for it is in the enzyme-linked immunosorbent assay (ELISA) to detect for binding of molecules to each other.

Itraconazole is a triazole antifungal agent. IC50 Value: N/A Target: antifungal in vitro: Itraconazole is pharmacologically distinct from other azole antifungal agents in that it is the only inhibitor in this class that has been shown to inhibit both the hedgehog signaling pathway and angiogenesis[1, 2].

ABT-333 is an NS5B non-nucleoside polymerase inhibitor. IC50 value: Target: HCV NS5B in vitro: in vivo: All patients received ABT-333 (400 mg twice daily) and ribavirin (1000 to 1200 mg per day) and one of two daily doses of ABT-450/r.

Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease. Target: HMGCR Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA...

Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. IC50 value: Target: Btk From PCT Int.