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Chemical Name:
AMG 837 calcium hydrate
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CAS No.:
1259389-38-2
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Appearances: White to off-white Solid |
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Synonyms: AMG-837 calcium hydrate;AMG... |
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Brief introduction:
AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
IC50 value: 13 nM (EC50) [1]
Target: GPR40 agonist
AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the rac...
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Chemical Name:
AMG 837 sodium salt
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CAS No.:
865231-45-4
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Synonyms: AMG-837 sodium salt;AMG837 ... |
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Brief introduction:
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
IC50 value: 13 nM (EC50) [1]
Target: GPR40 agonist
AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic...
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Chemical Name:
PEAQX
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CAS No.:
459836-30-7
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Synonyms: NVP-AAM077 |
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Brief introduction:
NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice.
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Chemical Name:
LY2857785
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CAS No.:
1619903-54-6
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: LY 2857785;LY-2857785; (1r,... |
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Brief introduction:
LY2857785 is a type I reversible and competitive ATP kinase inhibitor against <b>CDK9</b> (<b>IC<sub>50</sub></b> 11 nM) and other transcription kinases <b>CDK8</b> (<b>IC<sub>50</sub></b> 16 nM), and <b>CDK7</b> (<b>IC<sub>50</sub></b> 246 nM).
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Chemical Name:
(R)-(+)-Etomoxir sodium salt
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CAS No.:
828934-41-4
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: (+)-Etomoxir sodium salt; s... |
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Brief introduction:
(R)-(+)-Etomoxir (sodium salt) is a potent inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.
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Chemical Name:
IM-12
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CAS No.:
1129669-05-1
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: IM 12;IM12; 3-((4-fluorophe... |
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Brief introduction:
IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC<sub>50</sub></b> of 53 nM, and also enhances Wnt signalling.
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Chemical Name:
Nexturastat A
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CAS No.:
1403783-31-2
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 4-((1-butyl-3-phenylureido)... |
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Brief introduction:
Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.
IC50 value: 5 nM [1]
Target: HDAC6 inhibitor
Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6.
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Chemical Name:
kb-NB77-78
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CAS No.:
1350622-33-1
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: 9-((tert-butyldimethylsilyl... |
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Brief introduction:
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).
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Chemical Name:
MMAD hydrochloride
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CAS No.:
173441-26-4
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Purity: |
Appearances: White to off-white solid |
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Synonyms: Demethyldolastatin 10 hydro... |
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Brief introduction:
A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).
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Chemical Name:
3,4-Diethoxybenzonitrile
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CAS No.:
60758-87-4
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Synonyms: 3,4-diethoxybenzonitrile |
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Chemical Name:
Boc-Phe-OH
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CAS No.:
13734-34-4
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Synonyms: BOC-L-Phenylalanine;N-(tert... |
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Chemical Name:
HG6-64-1
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CAS No.:
1315329-43-1
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: HG-6-64-1;HG 6-64-1; (E)-N-... |
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Brief introduction:
HG6-64-1 is a potent and selective <b>B-Raf</b> inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a <b>IC<sub>50</sub></b> of 0.09 μM on B-raf V600E transformed Ba/F3 cells.
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Chemical Name:
4SC-202 free base
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CAS No.:
910462-43-0
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 4SC 202 free base;4SC202 fr... |
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Brief introduction:
4SC-202 free base is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs.
IC50 value:
Target: HDAC1/2/3
The novel HDACi 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes.
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Chemical Name:
Dictamnine
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CAS No.:
484-29-7
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: 4-Methoxyfuro[2,3-b]quinoli... |
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Brief introduction:
Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.
IC50 value:
Target:
Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a min...
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Chemical Name:
Arg-Gly-Asp-Ser
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CAS No.:
91037-65-9
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: RGDS peptide;Fibronectin In... |
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Brief introduction:
Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.
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Chemical Name:
Defactinib
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CAS No.:
1073154-85-4
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: VS-6063;VS6063;VS 6063; N-m... |
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Brief introduction:
Defactinib is a novel <b>FAK</b> inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
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