Apexbio Technology LLC

NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice.

LY2857785 is a type I reversible and competitive ATP kinase inhibitor against <b>CDK9</b> (<b>IC₅₀</b> 11 nM) and other transcription kinases <b>CDK8</b> (<b>IC₅₀</b> 16 nM), and <b>CDK7</b> (<b>IC₅₀</b> 246 nM).

(R)-(+)-Etomoxir (sodium salt) is a potent inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC₅₀</b> of 53 nM, and also enhances Wnt signalling.

Description

kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).

A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).

HG6-64-1 is a potent and selective <b>B-Raf</b> inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1); has a <b>IC₅₀</b> of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi. IC50 value: Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a min...

Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.

Defactinib is a novel <b>FAK</b> inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

Ozanimod is a potent and selective <b>S1P₁</b> and <b>S1P₅ receptor</b> agonist with <b>EC₅₀</b>s of 410±160 pM and 11±4.3 nM in [³⁵S]-GTPγS binding, respectively.

Description

Description

MLN1117 is a selective <b>p110α</b> inhibitor with an <b>IC₅₀</b> of 15 nM.

NVP-QAV-680 is a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. A highly selective compound, it has low nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro.

Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Ca...

GNE-9605 is a highly potent and selective <b>leucine-rich repeat kinase 2 (LRRK2)</b> inhibitor with <b>K_i</b> and <b>IC50</b> of 2 nM and 19 nM, respectively.

THZ2 is a potent and selective <b>CDK7</b> inhibitor with <b>IC₅₀</b> of 13.9 nM.

THZ2 is a potent and selective <b>CDK7</b> inhibitor with <b>IC₅₀</b> of 13.9 nM.