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AdooQ BioScience, LLC

477

Basic Information

Company Name:AdooQ BioScience, LLC

Business Type:Chemical manufacturer since 2006

Total NO.Employees:

Country/Region:USA

Certificates:

Year Established: 2006

Introduction of AdooQ BioScience, LLC

AdooQ BioScience is a supplier of biochemicals located in irvine, CA since 2006. In past five years, we have been a renowned name engaged in manufacturing and supplying small molecule inhibitors including kinase inhibitors on kinds of signal pathway, such as PI3K, AKT, HDAC, MARP etc.

Web: www.adooq.com TEL:855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) Fax:866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada) Email:[email protected]

Products of AdooQ BioScience, LLC

  • Chemical Name: AMG 837 (calcium hydrate)
    CAS No.: 1259389-38-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AMG-837 calcium hydrate;AMG... Quality Control & MSDS Files:
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    Brief introduction:

    AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the rac...

  • Chemical Name: AMG 837 (sodium salt)
    CAS No.: 865231-45-4 Purity: Appearances:
    Brand: Synonyms: AMG-837 sodium salt;AMG837 ... Quality Control & MSDS Files:
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    Brief introduction:

    AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic...

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC<sub>50</sub></b> of 53 nM, and also enhances Wnt signalling.

  • Chemical Name: Nexturastat A
    CAS No.: 1403783-31-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-((1-butyl-3-phenylureido)... Quality Control & MSDS Files:
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    Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms. IC50 value: 5 nM [1] Target: HDAC6 inhibitor Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6.

  • Chemical Name: 4SC-202 (free base)
    CAS No.: 910462-43-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4SC 202 free base;4SC202 fr... Quality Control & MSDS Files:
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    4SC-202 free base is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs. IC50 value: Target: HDAC1/2/3 The novel HDACi 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes.

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Defactinib is a novel <b>FAK</b> inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

  • Chemical Name: YH239-EE
    CAS No.: 1364488-67-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: YH 239-EE;YH 239 EE; ethyl ... Quality Control & MSDS Files:
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    YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction.

  • Chemical Name: PI-1840
    CAS No.: 1401223-22-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PI 1840;PI1840; N-isopropyl... Quality Control & MSDS Files:
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  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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  • Chemical Name: GNE-9605
    CAS No.: 1536200-31-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GNE 9605;GNE9605;N2-(5-chlo... Quality Control & MSDS Files:
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  • Chemical Name: Pirarubicin (Hydrochloride)
    CAS No.: 95343-20-7 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: THP Hydrochloride; (8S,10S)... Quality Control & MSDS Files:
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    Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. Target: Topoisomerase Pirarubicin is an anthracycline drug.

  • Chemical Name: AZ191
    CAS No.: 1594092-37-1 Purity: Appearances: light yellow to khaki Solid
    Brand: Synonyms: AZ 191; N-(2-methoxy-4-(4-m... Quality Control & MSDS Files:
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  • Chemical Name: FR 180204
    CAS No.: 865362-74-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: FR 180204;FR-180204; 5-(2-p... Quality Control & MSDS Files:
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    Brief introduction:

    FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively. IC50 value: 0.31 uM/0.14 uM(Ki for ERK1/ERK2); 0.51uM/0.33 μM(ERK1/ERK2) [1] [2] Target: ERK1/2 inhibitor in vi...

  • Chemical Name: ML347
    CAS No.: 1062368-49-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ML 347;ML-347;LDN-193719;LD... Quality Control & MSDS Files:
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    Brief introduction:

    ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs.

  • Chemical Name: CFTR(inh)-172
    CAS No.: 307510-92-5 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: CFTR Inhibitor-172;CFTRinh-... Quality Control & MSDS Files:
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    CFTR(inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki approximately 300 nM.

  • Chemical Name: DMH-1
    CAS No.: 1206711-16-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: DMH1;DMH 1; 4-(6-(4-isoprop... Quality Control & MSDS Files:
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    DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2. IC50 value: 27/107.9/<5 nM(ALK1/2/3) [1] Target: ALK inhibitor DMH-1 shows the most selectivity within these three compounds(LDN-193189, DMH-1 and dorsomorphin) [1].

  • Chemical Name: T-5224
    CAS No.: 530141-72-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: T5224;T 5224; 3-(5-(4-(cycl... Quality Control & MSDS Files:
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    Brief introduction:

    T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1, attenuates lipopolysaccharide-induced liver injury in mice. IC50 value: Target: c-Fos/AP1 inhibitor in vitro: T-5224 was converted to its acyl O-glucuronide (G2) by UGT1A1 and UGT1A3 and to its hydroxyl O-glucuronide (G3) by several UGTs, but it was not metabolized b...

  • Chemical Name: CB-839
    CAS No.: 1439399-58-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-(pyridin-2-yl)-N-(5-(4-(6... Quality Control & MSDS Files:
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    Brief introduction:

    CB-839 is a potent and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC), and with <b>IC<sub>50</sub></b>s of 23 nM and 28 nM in kidney and brain, respectively.

  • Chemical Name: EHT 1864
    CAS No.: 754240-09-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: EHT1864;EHT-1864; 2-(morpho... Quality Control & MSDS Files:
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    Brief introduction:

    EHT 1864 is a small molecule inhibitor of Rac1 signaling; modulate γ-Secretase-mediated APP processing. IC50 value: Target: Rac1 inhibitor in vitro: EHT 1864 blocks Aβ 40 and Aβ 42 production but does not impact sAPPα levels and does not inhibit γ-secretase.

  • Chemical Name: Z-VAD(OMe)-FMK
    CAS No.: 187389-52-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Z-Val-Ala-Asp(OMe)-FMK Quality Control & MSDS Files:
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    Brief introduction:

    Z-VAD(OMe)-FMK is a cell-permeable, <b>pan-caspase</b> inhibitor.