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Chemical Name:
Ketorolac
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CAS No.:
74103-06-3
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Synonyms: Acular LS;RS37619;Sprix;Tor... |
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Brief introduction:
Ketorolac(RS37619), a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug.
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Chemical Name:
Naratriptan
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CAS No.:
121679-13-8
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Synonyms: N-Methyl-2-[3-(1-methylpipe... |
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Brief introduction:
Naratriptan is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.
Target: 5-HT1 Receptor
Naratriptan is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches.
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Chemical Name:
Ketorolac (tromethamine salt)
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CAS No.:
74103-07-4
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Purity: |
Appearances: white Solid |
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Synonyms: Ketorolac tris salt;Toradol... |
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Brief introduction:
Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor with strong analgesic activity.
Target: COX
Ketorolac or ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic.
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Chemical Name:
Stavudine
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CAS No.:
3056-17-5
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: 2',3'-Didehydro-3'-deoxythy... |
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Brief introduction:
Stavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Target: HIV RT; NRTIs
Stavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
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Chemical Name:
Naratriptan (hydrochloride)
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CAS No.:
143388-64-1
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: N-Methyl-3-(1-methylpiperid... |
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Brief introduction:
Naratriptan hydrochloride is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.
Target: 5-HT1 Receptor
Naratriptan is a triptan drug marketed by GlaxoSmithKline and is used for the treatment of migraine headaches.
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Chemical Name:
Delafloxacin
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CAS No.:
189279-58-1
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Synonyms: Delafloxacinum;RX-3341;WQ-3... |
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Brief introduction:
Delafloxacin (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent.
IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1]
Target: Antibacterial
ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to th...
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Chemical Name:
CP-547632
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CAS No.:
252003-65-9
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Synonyms: 3-((4-bromo-2,6-difluoroben... |
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Brief introduction:
CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively).
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Chemical Name:
CHIR-98014
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CAS No.:
252935-94-7
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: CHIR98014;CHIR 98014; N2-(2... |
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Brief introduction:
CHIR-98014 is a selective GSK3 inhibitor with IC50s of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
IC50 value: 0.65 nM/0.58 nM (GSK-3α/GSK-3β) [1]
Target: GSK-3α/GSK-3β
Exposure of insulin receptor–expressing CHO-IR cells or primary rat hepatocyt...
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Chemical Name:
RepSox
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CAS No.:
446859-33-2
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: E-616452;SJN 2511;E616452;S... |
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Brief introduction:
RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
IC50 Value: 23 nM
Target: ALK5
in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction...
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Chemical Name:
LDN193189
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CAS No.:
1062368-24-4
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: LDN 193189; LDN-193189; DM-... |
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Brief introduction:
LDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
IC50 value: 5 nM/30 nM (ALK2/ALK3) [1]
Target: ALK2/3
in vitro: LDN193189 potently inhibits BMP4-med...
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Chemical Name:
Telatinib
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CAS No.:
332012-40-5
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Purity: |
Appearances: Light yellow to yellow Solid |
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Synonyms: Bay 57-9352 |
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Brief introduction:
Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of <b>VEGFR2</b>, <b> VEGFR3</b>, <b>PDGFα</b>, and <b>c-Kit</b> with <b>IC<sub>50</sub></b>s of 6, 4, 15 and 1 nM, respectively.
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Chemical Name:
BI-D1870
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CAS No.:
501437-28-1
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Purity: |
Appearances: White to off-white solid |
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Synonyms: BI-D 1870; 2-((3,5-difluoro... |
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Brief introduction:
BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
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Chemical Name:
LY2109761
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CAS No.:
700874-71-1
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Purity: |
Appearances: White to off-white solid |
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Synonyms: LY 2109761;LY-2109761; 4-(2... |
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Brief introduction:
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
IC50 value: 38 nM/300 nM(Ki, TβRI/II) [1]
Target: TGF-β receptor type I/II
in vitro: LY2109761 treatment induces a dose-dependent low-anchorage growth in...
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Chemical Name:
AMG 900
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CAS No.:
945595-80-2
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Purity: |
Appearances: Light yellow to yellow solid |
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Synonyms: AMG-900;AMG900; N-(4-((3-(2... |
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Brief introduction:
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.
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Chemical Name:
PHA-680632
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CAS No.:
398493-79-3
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Synonyms: PHA680632;PHA 680632; N-(2,... |
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Brief introduction:
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.
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Chemical Name:
Alisertib
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CAS No.:
1028486-01-2
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Purity: |
Appearances: Pink to red Solid |
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Synonyms: MLN 8237;MLN8237;MLN-8237; ... |
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Brief introduction:
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM; has >200-fold higher selectivity for Aurora A than Aurora B.
IC50 Value: 1.2 nM (Aurora A)
Target: Aurora A
in vitro: MLN8237 (0.5 μM) treatment inhibits the phosphorylation of Aurora A in MM1.S and OPM1 cells, without affecting the Aurora B mediated histone ...
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Chemical Name:
Selumetinib
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CAS No.:
606143-52-6
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: AZD6244; Array142886; ARRY-... |
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Brief introduction:
Selumetinib (AZD6244; ARRY-142886) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc.
IC50 value: 14 nM [1]
Target: MEK1
in vitro: ZD6244 is not competitive with ATP and inactivates the ERK1/2 phosphoryl...
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Chemical Name:
Navitoclax
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CAS No.:
923564-51-6
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Purity: |
Appearances: White to off-white Solid |
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Synonyms: ABT-263;ABT 263;ABT263; (R)... |
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Brief introduction:
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM.
IC50 Value: ≤ 0.5 nM(Ki for Bcl-xL); ≤1 nM(Ki for Bcl-2); ≤1 nM(Ki for Bcl-w)
Target: Bcl-2 Family
in vitro: ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, r...
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Chemical Name:
1,3,6,8-Tetrabromopyrene
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CAS No.:
128-63-2
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Synonyms: 1,3,6,8-tetrabromopyrene |
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Brief introduction:
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