ABX Advanced Biochemical Compounds

Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia. Target: GABA Receptor Etomidate is a potent inhibitor of the adrenal response to surgery.

Rolipram(SB95952; ZK62711) is a selective inhibitor of phosphodiesterases PDE 4, especially of the subtype PDE 4B (IC50=130nM), IC50 for PDE4D is 240 nM.

WIN35428 is a novel allosteric modulators of the dopamine transporter (DAT).

Alovudine is a reverse transcriptase inhibitor potentially for the treatment of HIV infection. A 4-week randomized, double-blind, placebo-controlled dose-ranging study concluded that alovudine 2 mg/day provided a modest but significant viral load reduction in patients harbouring viruses.

Metaraminol tartrate is an α1-adrenergic receptor agonist，is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia.

A highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors. Activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000-, 25000- and 140000-fold selective ...