• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

M-I

(CAS: )

Suppliers of M-I

Company Name Email Tel Country
AMEDCHEM [email protected] +862168061059 CHINA

Fax: Purity: Brand:

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of M-I

M-I is a metabolism of TAK-875. TAK-875 is a G protein-coupled receptor 40 agonist.

Solubility of M-I

Solubility Sources

Storage Condition of M-I

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase

Chemical Information

M.Wt Formula CAS No. Synonyms
362.44 C19H22O5S

Structure Information of M-I

Smiles C1(C2=C(C)C=C(OCCCS(C)(=O)=O)C=C2C)=CC=CC(C(O)=O)=C1
InChI InChI=1S/C19H22O5S/c1-13-10-17(24-8-5-9-25(3,22)23)11-14(2)18(13)15-6-4-7-16(12-15)19(20)21/h4,6-7,10-12H,5,8-9H2,1-3H3,(H,20,21)

Related Products

Other Form Products of M-I

Name CAS Formula Suppliers

Recommended Products in Same Target

Name CAS Formula Suppliers
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 9
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 6
GPR40 Activator 1 1309435-60-6 C31H31NO3S 6
AMG 837 865231-46-5 C26H21F3O3 12
TUG-770 1402601-82-4 C19H14FNO2 13
GW9508 885101-89-3 C22H21NO3 22
TAK-875 1000413-72-8 C29H32O7S 16
GW-1100 306974-70-9 C27H25FN4O4S 9
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 6
DC260126 346692-04-4 C32H31N5O 7
T-1676427 1000414-39-0 C29H32O8S 0
JTT-851 C23H28O3 0
Astellas C27H30N4O4 0
MK-2305 905723-46-8 C19H13ClF3NO4S 0
Mochida 1469495-84-8 C30H35NO6S 0
BMS-986118 1610562-74-7 C25H28ClF3N4O4 2
AM-6226 C32H36F2O4 0
GPR40 agonist 1 1312788-44-5 C24H20O3 0
GPR40 agonist 2 C25H22O3 0
GPR40 agonist 3 C23H18O3 0

Recommended Products in the Same Indication

Name CAS Formula Suppliers

Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Kogame A, et al. Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica. 2018 Mar 20:1-41.
1. The absorption, distribution, metabolism and excretion of fasiglifam were investigated in rats, dogs, and humans. 2. The absolute oral bioavailability of fasiglifam was high in all species (> 76.0%). 3. After oral administration of [14C]fasiglifam, the administered radioactivity was quantitatively recovered and the major route of excretion of radioactivity was via feces in all species. 4. Fasiglifam was a major component in the plasma and feces in all species. Its oxidative metabolite (M-I) was observed as a minor metabolite in rat and human plasma (< 10% of plasma radioactivity). In human plasma, hydroxylated fasiglifam (T-1676427), the glucuronide of fasiglifam (fasiglifam-G), and the glucuronide of M-I were detected as additional minor metabolites (< 2% of plasma radioactivity). None of these metabolites were specific to humans. Fasiglifam-G was the major components in the rat and dog bile. 5. In vitro cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) reaction phenotyping indicated that oxidation (to form M-I and T-1676427) and glucuronidation of fasiglifam are mainly mediated by CYP3A4/5 and UGT1A3, respectively. 6. Fasiglifam and fasiglifam-G are substrates of BCRP and Mrp2/MRP2, respectively. 7. Glucuronidation of fasiglifam-G was found to be the predominant elimination pathway of fasiglifam in all species tested, including humans.

Tags: buy M-I | M-I IC50 | M-I price | M-I cost | M-I solubility | M-I purchase | M-I manufacturer | M-I research buy | M-I order | M-I MSDS | M-I chemical structure | M-I Storage condition | M-I molecular weight | M-I mw | M-I datasheet | M-I supplier | M-I cell line | M-I NMR | M-I MS | M-I IR | M-I solubility | M-I Safe information | M-I Qc and Spectral Information | M-I Clinical Information | M-I Clinical Trial | M-I Route of Synthesis | M-I storage condition | M-I diseases and conditions | M-I flash point | M-I boiling point | M-I melting point | M-I storage condition | M-I brand