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EAI045

(CAS: 1942114-09-1)

Suppliers of EAI045

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD70/5mg (In stock) USD90/10mg (In stock) USD260/50mg (In stock) USD450/100mg (In stock) USD750/200mg (In stock) USD1300/500mg (In stock)
Quality Control & MSDS Files: LCMS LCMS LCMS HNMR HNMR HNMR HNMR LCMS LCMS LCMS MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand: ChemExpress

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Background Information of EAI045

EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants. target: EGFR [1] In vitro: EAI045 potently inhibit EGFR Y1173 phosphorylation in H1975 cells.

Solubility of EAI045

Solubility Sources
DMSO: ≥ 28 mg/mL CHEMSCENE, LLC
DMSO ≥ 28 mg/mL MedChemexpress Co., Ltd.

Storage Condition of EAI045

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
EAI045 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
383.4 C19H14FN3O3S 1942114-09-1 EAI 045;EAI-045; 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide

Structure Information of EAI045

Smiles O=C(C(C1=C(O)C=CC(F)=C1)N2C(C(C=CC=C3)=C3C2)=O)NC4=NC=CS4
InChI InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
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