AGN 195183
(CAS: 367273-07-2)
Background Information of AGN 195183
AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.
IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.)
Target: RARα agonist
Compound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation.
Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580.
Storage Condition of AGN 195183
Quality Control and Spectral Data
Mechanism and Indications
Clinical Information
| Product Name |
Sponsor & Collaborators |
Indications |
Start Date |
End Date |
Phase |
|
AGN 195183
|
- |
|
|
|
Phase 2 Clinical |
|
AGN 195183
|
- |
|
|
|
No Development Reported |
Chemical Information
| M.Wt |
Formula |
CAS No. |
Synonyms |
| 437.86 |
C22H22ClF2NO4 |
367273-07-2 |
AGN195183;AGN-195183; 4-(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)-2,6-difluorobenzoic acid |
Structure Information of AGN 195183
| Smiles |
O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F |
| InChI |
InChI=1S/C22H22ClF2NO4/c1-21(2)5-6-22(3,4)16-12(21)9-11(18(27)17(16)23)19(28)26-10-7-13(24)15(20(29)30)14(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30) |
Related Products
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CAS |
Formula |
Suppliers |
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Safety Data of AGN 195183
Chemical and Physical Properties
| Appearance:White to off-white Solid |
Melting point: |
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| Water Solubility: |
Solubility:Soluble in DMSO, not in water |
| Density: |
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EINECS: |
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