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ITD-1

(CAS: 1099644-42-4)

Suppliers of ITD-1

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD21/1mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD90/5mg (In stock) USD120/10mg (In stock) USD440/50mg (In stock) USD650/100mg (In stock)
Quality Control & MSDS Files: LCMS HNMR MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand: ChemExpress

Tocris Bioscience Inc. [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #98 % Brand: Tocris

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Background Information of ITD-1

ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50 = 0.85 μM). IC50 value: 0.85 μM Target: TGFβ in vitro: ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells.

Solubility of ITD-1

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming Tocris Bioscience Inc.

Storage Condition of ITD-1

Storage Condition Sources
4°C MedChemexpress Co., Ltd.
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
ITD-1 - Not Found
ITD-1 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
415.52 C27H29NO3 1099644-42-4 ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Structure Information of ITD-1

Smiles O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC
InChI InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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