• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

EGF816

(CAS: 1508250-71-2)

Suppliers of EGF816

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD350/5mg (In stock) USD500/10mg (In stock) USD1500/50mg (In stock) USD2100/100mg (In stock)
Quality Control & MSDS Files: LCMS NP-HPLC NP-HPLC NP-HPLC NP-HPLC HNMR MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand: ChemExpress

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of EGF816

EGF816 is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC.

Solubility of EGF816

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of EGF816

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications NSCLC Non Small Cell Lung Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
EGF816 Novartis Pharmaceuticals NSCLC 2014/4/07 Phase 2
EGF816 Novartis Pharmaceuticals Non Small Cell Lung Cancer 2014/12/18 Phase 2
EGF816 - Phase 2 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
495.02 C26H31ClN6O2 1508250-71-2 EGF-816;Nazartinib; (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide

Structure Information of EGF816

Smiles O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[[email protected]]4CN(C(/C=C/CN(C)C)=O)CCCC4
InChI InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

Related Products

Other Form Products of EGF816

Name CAS Formula Suppliers
EGF816 (S enantiomer) 1508256-20-9 C26H31ClN6O2 3
EGF816 (mesylate) 1508250-72-3 C27H35ClN6O5S 3

Recommended Products in Same Target

Name CAS Formula Suppliers
Ginsenoside Rh2 78214-33-2 C36H62O8 6
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 6
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 4
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 5
AZD-9291 1421373-65-0 C28H33N7O2 16
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 4
WHI-P180 211555-08-7 C16H15N3O3 5
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 6
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 4
BGB-102 807640-87-5 C22H25BrN4O2 4
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 10
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 10
CO-1686 1374640-70-6 C27H28F3N7O3 9
CNX-2006 1375465-09-0 C26H27F4N7O2 8
PD 168393 194423-15-9 C17H13BrN4O 12
AG 18 118409-57-7 C10H6N2O2 14
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 9
Chrysophanic acid 481-74-3 C15H10O4 18
AG-1478 153436-53-4 C16H14ClN3O2 10
Mubritinib 366017-09-6 C25H23F3N4O2 22

Recommended Products in the Same Indication

Name CAS Formula Suppliers
EGF816 (mesylate) 1508250-72-3 C27H35ClN6O5S 3
AZD-9291 1421373-65-0 C28H33N7O2 16

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Tags: buy EGF816 | EGF816 IC50 | EGF816 price | EGF816 cost | EGF816 solubility | EGF816 purchase | EGF816 manufacturer | EGF816 research buy | EGF816 order | EGF816 MSDS | EGF816 chemical structure | EGF816 Storage condition | EGF816 molecular weight | EGF816 mw | EGF816 datasheet | EGF816 supplier | EGF816 cell line | EGF816 NMR | EGF816 MS | EGF816 IR | EGF816 solubility | EGF816 Safe information | EGF816 Qc and Spectral Information | EGF816 Clinical Information | EGF816 Clinical Trial | EGF816 Route of Synthesis | EGF816 storage condition | EGF816 diseases and conditions | EGF816 flash point | EGF816 boiling point | EGF816 melting point | EGF816 storage condition | EGF816 brand