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EGF816

(CAS: 1508250-71-2)

Suppliers of EGF816

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()
Quality Control & MSDS Files: LCMS NP-HPLC NP-HPLC NP-HPLC NP-HPLC HNMR MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

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Background Information of EGF816

EGF816 is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC.

Solubility of EGF816

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of EGF816

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications NSCLC Non Small Cell Lung Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
EGF816 Novartis Pharmaceuticals NSCLC 2014/4/07 Phase 2
EGF816 Novartis Pharmaceuticals Non Small Cell Lung Cancer 2014/12/18 Phase 2
EGF816 - Phase 2 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
495.02 C26H31ClN6O2 1508250-71-2 EGF-816;Nazartinib; (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide

Structure Information of EGF816

Smiles O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[[email protected]]4CN(C(/C=C/CN(C)C)=O)CCCC4
InChI InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

Related Products

Other Form Products of EGF816

Name CAS Formula Suppliers
EGF816 (S-enantiomer) 1508256-20-9 C26H31ClN6O2 3
EGF816 (mesylate) 1508250-72-3 C27H35ClN6O5S 5

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Recommended Products in the Same Indication

Name CAS Formula Suppliers
EGF816 (mesylate) 1508250-72-3 C27H35ClN6O5S 5
AZD-9291 1421373-65-0 C28H33N7O2 18

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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