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A-1155463

(CAS: 1235034-55-5)

Suppliers of A-1155463

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD140/5mg (In stock) USD210/10mg (In stock) USD700/50mg (In stock) USD1150/100mg (In stock)
Quality Control & MSDS Files: LCMS HNMR MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand: ChemExpress

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Background Information of A-1155463

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM). IC50 value: <0.01 nM (Ki) [1] Target: BCL-XL in vitro: A-1155463 represents an excellent tool molecule for studying BCL-XL biology as well as a productive lead structure for further optimization.

Solubility of A-1155463

Solubility Sources
DMSO: 31mg/ml CHEMSCENE, LLC
DMSO: 31mg/ml MedChemexpress Co., Ltd.

Storage Condition of A-1155463

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Apoptosis
Target Bcl-2 Family
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A-1155463 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
669.79 C35H32FN5O4S2 1235034-55-5 A1155463;A 1155463; 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid

Structure Information of A-1155463

Smiles O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
InChI InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)

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Chemical and Physical Properties

Appearance:light yellow to khaki Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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