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Combretastatin A4

(CAS: 117048-59-6)

Suppliers of Combretastatin A4

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing Tianjia Chemical Science & Technology Co., Ltd. [email protected] +86 (550) 702-1925 China

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD96/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Great Forest Biomedical Ltd. [email protected],[email protected] +86 (571) 2831-3180 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD96/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD96/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD83/10mg () USD165/25mg () USD312/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of Combretastatin A4

Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

Solubility of Combretastatin A4

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.
Soluble to 100 mM in ethanol and to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Combretastatin A4

Storage Condition Sources
Desiccate at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Cytoskeleton
Target Microtubule/Tubulin
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Combretastatin A4 - Phase 3 Clinical
Combretastatin A4 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
316.35 C18H20O5 117048-59-6 (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol; (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenol

Structure Information of Combretastatin A4

Smiles COC1=C(OC)C=C(/C=CC2=CC(O)=C(OC)C=C2)C=C1OC
InChI InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-

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Safety Data of Combretastatin A4

Hazard Symbols:T Risk Statements:R23/24/25;R41 Safety Statements:S26;S36/37;S39;S45
Transport Information:UN 2811 HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance: Melting point:84.5-85.5°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,63 mg/mL(199.14 mM);In vitro:Ethanol,34 mg/mLwarmed(107.47 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+50% PEG 300+ddH2OFor best results,
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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