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AZD-5438

(CAS: 602306-29-6)

Suppliers of AZD-5438

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >98% Brand:

Price and Availability: USD995/100mg (In stock) USD1550/250mg (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BLD Pharmatech [email protected] +86-21-61629022

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD72/10mg () USD216/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Excenen Pharmatech Co., Ltd. [email protected] +86 (20) 8565-3352 China

Fax: +86 (20) 8565-3397Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/10mg () USD216/50mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD150/10mg (In stock) USD195/10mM/1mLIn DMSO (In stock) USD570/50mg (In stock) USD1670/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/10mg () USD216/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .987 Brand: TargetMol

Price and Availability: USD114/10mg () USD198/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of AZD-5438

AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM.

Solubility of AZD-5438

Solubility Sources
DMSO ≥71 mg/mL Water <1.2 mg/mL Ethanol ≥71 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 74 mg/mL (199.21 mM); Ethanol74 mg/mL (199.21 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of AZD-5438

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Desiccate at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AZD-5438 - Discontinued
AZD-5438 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
371.46 C18H21N5O2S 602306-29-6 AZD 5438;AZD5438; 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine

Structure Information of AZD-5438

Smiles O=S(C1=CC=C(NC2=NC(C3=CN=C(N3C(C)C)C)=CC=N2)C=C1)(C)=O
InChI InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)

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Other Form Products of AZD-5438

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JNJ-17203212 821768-06-3 C17H15F6N5O 11
DM1-SMe 138148-68-2 C36H50ClN3O10S2 6
ML247 1222374-44-8 C18H24N4O3S 1
Tubercidin 69-33-0 C11H14N4O4 14
Timegadine 71079-19-1 C20H23N5S 3
Bamaluzole 87034-87-5 C14H12ClN3O 3
Cholest-4-en-3-one, oxime, (3E)- 66538-08-7 C27H45NO 1
Bevenopran 676500-67-7 C20H26N4O4 6
Vibunazole 80456-55-9 C15H20ClN3O2 6
Pparδ agonist 2 870884-12-1 C20H18F3N3O3S 3

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Purvalanol B 212844-54-7 C20H25ClN6O3 22

Recommended Products in the Same Indication

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,74 mg/mL(199.21 mM);In vitro:Ethanol,74 mg/mL(199.21 mM);In vitro:Water,Insoluble;
Density:1.31 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Camidge, D. Ross; Pemberton, Mike; Growcott, Jim; A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers. Cancer Chemotherapy and Pharmacology (2007), 60(4), 479-488.

[2].Camidge, D. Ross; Smethurst, Dominic; A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers. Cancer Chemotherapy and Pharmacology (2007), 60(3), 391-398.

[3].Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D.AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells.Int J Radiat Oncol Biol Phys. 2012 Jul 12.

[4].Boss DS, Schwartz GK, Middleton MR, Amakye DD, Swaisland H, Midgley RS, Ranson M, Danson S, Calvert H, Plummer R, Morris C, Carvajal RD, Chirieac LR, Schellens JH, Shapiro GI.Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours.Ann Oncol. 2010 Apr;21(4):884-94. Epub 2009 Oct 13.

[5].Byth KF, Thomas A, Hughes G, Forder C, McGregor A, Geh C, Oakes S, Green C, Walker M, Newcombe N, Green S, Growcott J, Barker A, Wilkinson RW.AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.Mol Cancer Ther. 2009 Jul;8(7):1856-66. Epub 2009 Jun 9.

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