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(CAS: 698387-09-6)

Suppliers of Neratinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD15/1mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

Price and Availability: USD75/10mg (In stock) USD140/50mg (In stock) USD220/100mg (In stock)

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD49/5mg (In stock) USD76/10mg (In stock) USD99/25mg (In stock) USD147/50mg (In stock) USD238/100mg (In stock) USD438/200mg (In stock) USD672/500mg (In stock) USD1170/1g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD50/5mg (In stock) USD75/10mg (In stock) USD140/50mg (In stock) USD220/100mg (In stock) USD290/200mg (In stock)
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 97% Brand:

Price and Availability: USD62/100mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD150/5mg (In stock) USD360/10mM/1mLIn DMSO (In stock) USD470/25mg (In stock) USD1270/100mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD143/5mg (In stock) USD440/25mg (In stock) USD1188/100mg (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD96/2mg () USD170/5mg () USD299/10mg () USD850/50mg ()

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Background Information of Neratinib

Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively. IC50 value: 59 nM/92 nM (HER2/EGFR) [1] Target: HER2/EGFR in vitro: Neratinib weakly inhibits tyrosine kinases KDR and Src with IC50 of 0.8 μM and 1.4 μM, respectively, being 14- and 24-fold less active compared with HER2.

Solubility of Neratinib

Solubility Sources
Soluble in DMSO at 2 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO:< 5.6 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 2 mg/mL (3.59 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol5 mg/mL Selleck Chemicals LLC

Storage Condition of Neratinib

Storage Condition Sources
Store at or below -20 oC. LC Laboratoies
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications Metastatic breast cancer Breast tumor Solid tumor Non-small-cell lung cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Neratinib Puma Biotechnology Inc Metastatic breast cancer 2013/3/31 2018/5/31 Phase 3 Clinical
Neratinib Puma Biotechnology Inc Breast tumor 2009/7/31 2013/10/31 Phase 3 Clinical
Neratinib Puma Biotechnology Inc Solid tumor 2013/9/30 2015/12/31 Phase 2 Clinical
Neratinib Puma Biotechnology Inc Non-small-cell lung cancer 2013/5/31 2016/4/30 Phase 2 Clinical
Neratinib Washington University in St Louis Metastatic breast cancer 2012/12/31 2017/11/30 Phase 2 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
557.04 C30H29ClN6O3 698387-09-6 HKI-272;HKI272;HKI 272; (E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

Structure Information of Neratinib

Smiles ClC1=C(OCC2=NC=CC=C2)C=CC(NC3=C(C#N)C=NC4=CC(OCC)=C(NC(/C=C/CN(C)C)=O)C=C43)=C1
InChI InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+

Related Products

Other Form Products of Neratinib

Name CAS Formula Suppliers
Desmethyl Neratinib 915788-27-1 C29H27ClN6O3 1

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Chemical and Physical Properties

Appearance:yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.33 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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