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Everolimus

(CAS: 159351-69-6)

Suppliers of Everolimus

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

Price and Availability: USD11/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >99 % Brand:

Price and Availability: USD1550/500mg (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD198/100mg (In stock)

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Dimysh ( ShangHai ) Trading Co., Ltd. [email protected],[email protected] +86 (21) 5109-7611 China

Fax: +86 (21) 5109-7633Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: Brand:

Price and Availability: USD43/5mg (In stock) USD72/10mg (In stock) USD129/25mg (In stock) USD194/50mg (In stock) USD298/100mg (In stock) USD665/250mg (In stock) USD755/300mg (In stock) USD1130/500mg (In stock) USD1960/1g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS NP-HPLC HNMR HNMR LCMS LCMS LCMS LCMS NP-HPLC HNMR HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

ProbeChem [email protected] 86-21-80183644

Fax: 86-21-68860190Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD110/10mg (In stock) USD210/25mg (In stock) USD220/10mM/1mLIn DMSO (In stock) USD670/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()

Suzhou Unite Pharmtech Co., Ltd. [email protected],[email protected] +86 (512) 8766-6020 / +86 13222993784 China

Fax: +86 (512) 8217-7310Purity: Brand:

Taizhou Crene Biotechnology Co., Ltd. [email protected] +86 (576) 8881-3233 / 8820-5808 / +86 13396860566 China

Fax: +86 (576) 8822-9589Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD33/5mg () USD55/10mg () USD88/20mg () USD203/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Xingcheng Chempharm Co., Ltd. [email protected] +86 (576) 8855-1200 / 8852-5005 / 8888-0039 China

Fax: +86 (576) 8822-5056Purity: Brand:

ZHIYU Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 6279-1916 / +86 18912796596 China

Fax: +86 (512) 6279-1915Purity: Brand:

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Background Information of Everolimus

Everolimus (RAD001) is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. IC50 value: 1.6-2.4 nM [1] Target: mTOR (FKBP12) in vitro: Everolimus exhibits the immunosuppressive activity which is comparable to that of rapamycin.

Solubility of Everolimus

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 100 mg/mL; soluble in ethanol at 100 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
Soluble in DMSO and ethanol, up to about 25 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 30 mg/mL (31.3 mM); Ethanol7 mg/mL (7.3 mM); Water<1 mg/mL (<1 mM); In vivo 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O5mg/mL Selleck Chemicals LLC

Storage Condition of Everolimus

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR
Target mTOR
Research Area Cancer
Indications Metastatic breast cancer Coronary artery disease Kidney transplantation Restenosis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Everolimus - Launched
Everolimus Novartis AG Metastatic breast cancer 2013/1/31 2014/12/31 Phase 4 Clinical
Everolimus Abbott Vascular Coronary artery disease 2008/7/31 2011/3/31 Phase 4 Clinical
Everolimus Kyoto University Coronary artery disease 2010/2/28 2014/5/31 Phase 4 Clinical
Everolimus Yonsei University Kidney transplantation 2009/6/30 2013/2/28 Phase 4 Clinical
Everolimus Seoul National University Hospital Restenosis 2010/3/24 Phase 4 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
958.22 C53H83NO14 159351-69-6 Afinitor®;Certican;NVP-RAD001;RAD001

Structure Information of Everolimus

Smiles O=C(C([[email protected]]([[email protected]](C)CC1)(O)O[[email protected]@H]1C[[email protected]](OC)/C(C)=C/C=C/C=C/[[email protected]@H](C)C[[email protected]@H](C)C2=O)=O)N(CCCC3)[[email protected]@H]3C(O[[email protected]@H](CC([[email protected]](C)/C=C(C)/[[email protected]@H](O)[[email protected]]2OC)=O)[[email protected]](C)C[[email protected]]4C[[email protected]@H](OC)[[email protected]](OCCO)CC4)=O
InChI InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

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Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 22

Safety Data of Everolimus

Hazard Symbols:T,Xn,F Risk Statements:48/25-36-20/21/22-11 Safety Statements:45-36/37-26-16
Transport Information: HS Code: RTECS:
WGK Germany:2

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:NA
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(104.36 mM);In vitro:Ethanol,7 mg/mL(7.3 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% Propylene glycol (dissolve first)+5% Tween 80+d
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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