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Nilotinib

(CAS: 641571-10-0)

Suppliers of Nilotinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD6/1mg ()

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >99% Brand:

Price and Availability: USD985/1g (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()

Haikou Hengkangda Chemical Co., Ltd. [email protected] +86 (898) 3198-9500 China

Fax: +86 (898) 3198-9501Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD48/100mg (In stock) USD72/250mg (In stock) USD81/300mg (In stock) USD128/500mg (In stock) USD207/1g (In stock) USD382/2g (In stock) USD825/5g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Nanjing Ange Pharmaceutical Co., Ltd. [email protected] +86 (25) 8621-5454 China

Fax: +86 (25) 8650-1191Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD70/25mg (In stock) USD91/10mM/1mLIn DMSO (In stock) USD210/100mg (In stock) USD470/300mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()

Shanghai Twisun Bio-pharm Co., Ltd. [email protected],[email protected] +86 (21) 3728-5587 China

Fax: +86 (21) 3728-5115Purity: Brand:

Suzhou Howsine Biological Technology Co., Ltd. [email protected],[email protected] +86 (512) 6812-8052 China

Fax: +86 (512) 6812-8051Purity: Brand:

Taizhou Taifeng Chemical Co., Ltd. [email protected] +86 (576) 8885-0501 China

Fax: +86 (576) 8885-0502Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD25/5mg () USD75/25mg () USD168/100mg ()

Zhangjiagang Sunrise Fine Chemical Co., Ltd. [email protected] +86 (574) 8797-0832 China

Fax: +86 (574) 8770-1738Purity: Brand:

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Nilotinib

Nilotinib (AMN-107) is a Bcr-Abl inhibitor with IC50 less than 30 nM. IC50 value: < 30 nM [1] Target: Bcr-Abl in vitro: Nilotinib (AMN107) is significantly more potent against BCR-ABL than imatinib, and is active against many imatinib-resistant BCR-ABL mutants [1].

Solubility of Nilotinib

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 50 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO ≥10mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 27 mg/mL (50.98 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O3mg/mL Selleck Chemicals LLC

Storage Condition of Nilotinib

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK Autophagy
Target Bcr-Abl Autophagy
Research Area Cancer
Indications Chronic myelocytic leukemia

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Nilotinib Novartis AG Chronic myelocytic leukemia 2008/12/31 Phase 4 Clinical
Nilotinib Novartis AG Chronic myelocytic leukemia 2010/11/30 2017/12/31 Phase 4 Clinical
Nilotinib Novartis AG Chronic myelocytic leukemia 2012/4/30 2014/3/31 Phase 4 Clinical
Nilotinib Novartis AG Chronic myelocytic leukemia 2009/2/28 2013/6/30 Phase 4 Clinical
Nilotinib Novartis AG Chronic myelocytic leukemia 2010/3/31 2011/8/31 Phase 4 Clinical
Nilotinib - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
529.52 C28H22F3N7O 641571-10-0 AMN-107; Tasigna; AMN107; 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Structure Information of Nilotinib

Smiles O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3
InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)

Related Products

Other Form Products of Nilotinib

Name CAS Formula Suppliers
Nilotinib (monohydrochloride monohydrate) 923288-90-8 C28H25ClF3N7O2 7
Nilotinib (D6) 1268356-17-7 C28H16D6F3N7O 2
(±)-IP-66 58013-09-5 C20H27N3O2 1
PD-159020 177904-00-6 C32H25NO8 3
NVX-207 745020-66-0 C36H59NO6 3
Ethyl dirazepate 23980-14-5 C18H14Cl2N2O3 3
RPH-2823 96558-24-6 C17H22N8O2 3
Tulopafant 116289-53-3 C25H19N3O2S 4
Fibracillin 51154-48-4 C26H28ClN3O6S 3
4-[3-(4-Fluorophenyl)-2-hydroxy-1-(1H-1,2,4-triazol-1-yl)propyl]benzonitrile 204714-56-7 C18H15FN4O 1
Piridocaine (monohydrochloride) 69780-83-2 C14H21ClN2O2 1
Symetine 15599-45-8 C30H48N2O2 3

Recommended Products in Same Target

Name CAS Formula Suppliers
XL228 898280-07-4 C22H31N9O 11
Dasatinib (hydrochloride) 854001-07-3 C22H27Cl2N7O2S 6
GNF-5 778277-15-9 C20H17F3N4O3 13
Radotinib 926037-48-1 C27H21F3N8O 4
Flumatinib (mesylate) 895519-91-2 C30H33F3N8O4S 7
Flumatinib 895519-90-1 C29H29F3N8O 4
GZD824 1257628-77-5 C29H27F3N6O 8
ZM 306416 690206-97-4 C16H13ClFN3O2 9
Nocodazole 31430-18-9 C14H11N3O3S 19
Nilotinib (monohydrochloride monohydrate) 923288-90-8 C28H25ClF3N7O2 7
Imatinib (Mesylate) 220127-57-1 C30H35N7O4S 20
AST 487 630124-46-8 C26H30F3N7O2 6
DCC-2036 1020172-07-9 C30H28FN7O3 9
Bafetinib 859212-16-1 C30H31F3N8O 17
GNF-7 839706-07-9 C28H24F3N7O2 9
PD173955 260415-63-2 C21H16Cl2N4OS 7
WP1130 856243-80-6 C19H18BrN3O 9
DPH 484049-04-9 C18H13FN4O2 4
Ponatinib 943319-70-8 C29H27F3N6O 13
Lyn-IN-1 887650-05-7 C30H31F3N8O 6

Recommended Products in the Same Indication

Name CAS Formula Suppliers
Panobinostat 404950-80-7 C21H23N3O2 15
Imatinib (hydrochloride) 862366-25-4 C29H32ClN7O 1
Imatinib (Mesylate) 220127-57-1 C30H35N7O4S 21
Dasatinib (hydrochloride) 854001-07-3 C22H27Cl2N7O2S 6
Danusertib 827318-97-8 C26H30N6O3 10
Bosutinib 380843-75-4 C26H29Cl2N5O3 12
Lonafarnib 193275-84-2 C27H31Br2ClN4O2 15
PHA-680632 398493-79-3 C28H35N7O2 8
Dasatinib 302962-49-8 C22H26ClN7O2S 19
Imatinib (Mesylate) 220127-57-1 C30H35N7O4S 20
BMS-833923 1059734-66-5 C30H27N5O 12
DCC-2036 1020172-07-9 C30H28FN7O3 9
Nilotinib (monohydrochloride monohydrate) 923288-90-8 C28H25ClF3N7O2 7
Ponatinib 943319-70-8 C29H27F3N6O 13

Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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