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Erlotinib (Hydrochloride)

(CAS: 183319-69-9)

Suppliers of Erlotinib (Hydrochloride)

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD9/1mg ()

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: ≥98% Brand:

Price and Availability: USD400/100mg (In stock) USD685/500mg (In stock)
Quality Control & MSDS Files: CoA MSDS

AnHui HaiKang Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (579) 8764-5148 / +86 13335996519 China

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

Beijing Huikang Boyuan Chemical Tech Co., Ltd. [email protected],[email protected] +86 (10) 6886-2197 / 6886-7502 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD50/100mg (In stock) USD75/500mg (In stock)

Haikou Hengkangda Chemical Co., Ltd. [email protected] +86 (898) 3198-9500 China

Fax: +86 (898) 3198-9501Purity: Brand:

Hangzhou Hexo Chemtech Co., Ltd. [email protected],[email protected] +86 (571) 5663-8036 China

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Hunan OUYA Biological Co., Ltd. [email protected] +86 (592) 578-9921 China

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Janlon Biopharma Co., Ltd. [email protected] +86 (512) 6790-9115 China

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD37/500mg (In stock) USD55/1g (In stock) USD85/2g (In stock) USD160/5g (In stock) USD260/10g (In stock) USD590/25g (In stock) USD1840/100g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD50/100mg (In stock) USD75/500mg (In stock)
Quality Control & MSDS Files: HNMR LCMS MSDS

Nanjing Ange Pharmaceutical Co., Ltd. [email protected] +86 (25) 8621-5454 China

Fax: +86 (25) 8650-1191Purity: Brand:

Nanjing Pharmaluxury Co., Ltd. [email protected] +86 (25) 8178-7427 China

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 97% Brand:

Price and Availability: USD55/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD147/100mg (In stock) USD191/10mM/1mLIn DMSO (In stock) USD370/500mg (In stock)
Quality Control & MSDS Files: HNMR HPLC

Shanghai Amadis Bio-Technology Co., Ltd [email protected] (852)-2815 8172 CHINA

Fax: +86-21-36162076Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD55/100mg (In stock) USD165/500mg (In stock)

Suzhou Howsine Biological Technology Co., Ltd. [email protected],[email protected] +86 (512) 6812-8052 China

Fax: +86 (512) 6812-8051Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD20/10mg () USD74/50mg () USD132/100mg ()

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Background Information of Erlotinib (Hydrochloride)

Erlotinib Hcl(NSC 718781; OSI-774; CP-358774) is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM. IC50 Value: 2 nM [1] in vitro: CP-358,774 inhibits the proliferation of DiFi human colon tumor cells at submicromolar concentrations in cell culture and blocks cell cycle progression at the G1 phase.

Solubility of Erlotinib (Hydrochloride)

Solubility Sources
Limited solubility Apexbio Technology LLC
Soluble in DMSO at 18 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO ≥2.8mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 3 mg/mL (6.97 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 15% Captisol16 mg/mL warmed Selleck Chemicals LLC

Storage Condition of Erlotinib (Hydrochloride)

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Erlotinib (Hydrochloride) Roche Holding AG Metastatic non small cell lung cancer 2010/6/30 2013/7/31 Phase 4 Clinical
Erlotinib (Hydrochloride) Roche Holding AG Non-small-cell lung cancer 2008/4/30 2012/8/31 Phase 4 Clinical
Erlotinib (Hydrochloride) Roche Holding AG Non-small-cell lung cancer 2009/4/30 2010/12/31 Phase 4 Clinical
Erlotinib (Hydrochloride) Roche Holding AG Metastatic non small cell lung cancer 2004/11/30 2011/8/31 Phase 4 Clinical
Erlotinib (Hydrochloride) Roche Holding AG Metastatic non small cell lung cancer 2012/1/31 2014/12/31 Phase 3 Clinical
Erlotinib (Hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
429.9 C22H24ClN3O4 183319-69-9 N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride; 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride; Tarceva; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride

Structure Information of Erlotinib (Hydrochloride)

Smiles C#CC1=CC(NC2=NC=NC3=C2C=C(OCCOC)C(OCCOC)=C3)=CC=C1.Cl
InChI InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

Related Products

Other Form Products of Erlotinib (Hydrochloride)

Name CAS Formula Suppliers
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 4
Erlotinib impurity B 183321-83-7 C21H20ClN3O3 2
Erlotinib impurity A 183321-85-9 C21H20ClN3O3 2
Erlotinib 183321-74-6 C22H16D8ClN3O4 15
Erlotinib (D6 hydrochloride) 1189953-78-3 C22H18D6ClN3O4 1

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Name CAS Formula Suppliers
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AT-101 90141-22-3 C30H30O8 13
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Retaspimycin 857402-23-4 C31H45N3O8 4
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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:223-225°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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