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Temsirolimus

(CAS: 162635-04-3)

Suppliers of Temsirolimus

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >99 % Brand:

Price and Availability: USD760/250mg (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Dimysh ( ShangHai ) Trading Co., Ltd. [email protected],[email protected] +86 (21) 5109-7611 China

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Guangzhou Medcan Pharmatech Ltd. [email protected] +86 (20) 6130-2895 China

Fax: +86 (20) 6130-2895Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD47/10mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD134/10mM/1mLIn DMSO (In stock) USD147/10mg (In stock) USD270/25mg (In stock) USD370/50mg (In stock) USD870/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

Taizhou Crene Biotechnology Co., Ltd. [email protected] +86 (576) 8881-3233 / 8820-5808 / +86 13396860566 China

Fax: +86 (576) 8822-9589Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD78/10mg () USD133/25mg () USD209/50mg () USD343/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of Temsirolimus

Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. IC50 value: 1.76 uM [1] Target: mTOR in vitro: In the absence of FKBP12, Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM.

Solubility of Temsirolimus

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 200 mg/mL; soluble in ethanol at 200 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
(25°C) * In vitro DMSO 75 mg/mL (72.79 mM); Ethanol75 mg/mL (72.79 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol10 mg/mL Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Temsirolimus

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies
Store at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
Affix Scientific

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR
Target mTOR
Research Area Cancer
Indications Renal cell carcinoma Mantle cell lymphoma

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Temsirolimus Pfizer Inc Renal cell carcinoma 2013/6/30 2015/2/28 Phase 4 Clinical
Temsirolimus Pfizer Inc Renal cell carcinoma 2011/9/30 2015/8/31 Phase 4 Clinical
Temsirolimus Pfizer Inc Renal cell carcinoma 2010/10/31 2018/10/31 Phase 4 Clinical
Temsirolimus Pfizer Inc Mantle cell lymphoma 2011/3/31 2015/4/30 Phase 4 Clinical
Temsirolimus Pfizer Inc Renal cell carcinoma 2008/4/30 2013/12/31 Phase 3 Clinical
Temsirolimus - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
1030.29 C56H87NO16 162635-04-3 Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate;

Structure Information of Temsirolimus

Smiles O=C(C([[email protected]]([[email protected]](C)CC1)(O)O[[email protected]@H]1C[[email protected]](OC)/C(C)=C/C=C/C=C/[[email protected]@H](C)C[[email protected]@H](C)C2=O)=O)N(CCCC3)[[email protected]@H]3C(O[[email protected]@H](CC([[email protected]](C)/C=C(C)/[[email protected]@H](O)[[email protected]]2OC)=O)[[email protected]](C)C[[email protected]]4C[[email protected]@H](OC)[[email protected]](OC(C(CO)(C)CO)=O)CC4)=O
InChI InChI=1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:99-101°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Ethanol,75 mg/mL(72.79 mM);In vitro:DMSO,67 mg/mL(65.03 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+30% PEG 300 +2% Tween 80+ddH2OFor best res
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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