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(CAS: 301836-41-9)

Suppliers of SB-431542

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD17/1mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Price and Availability: USD198/50mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD96/10mg () USD360/50mg ()

Chemfuture Pharma Tech (Jiangsu) Ltd. [email protected],[email protected] +86 (510) 8538-6188 / 8538-6988 China

Fax: +86 (510) 8522-0778Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD96/10mg () USD360/50mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Quality Control & MSDS Files: CoA HNMR HPLC MS MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 97% Brand:

Price and Availability: USD65/10mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD110/10mg (In stock) USD143/10mM/1mLIn DMSO (In stock) USD470/50mg (In stock) USD1270/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/10mg () USD360/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD80/10mg () USD266/50mg () USD475/100mg ()

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Background Information of SB-431542

SB-431542 is potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM) and its relatives ALK4 and ALK7.

Solubility of SB-431542

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
DMSO ≥75mg/mL Water <1.2mg/mL Ethanol ≥42mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
DMSO 77 mg/mL (200 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol 3 mg/mL (7 mM) Selleck Chemicals LLC

Storage Condition of SB-431542

Storage Condition Sources
Store at RT Apexbio Technology LLC
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [MS] MedKoo Biosciences, Inc.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SB-431542 - Not Found
SB-431542 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
384.39 C22H16N4O3 301836-41-9 SB 431542; SB431542; 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

Structure Information of SB-431542

Smiles O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
InChI InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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