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PD153035 (Hydrochloride)

(CAS: 183322-45-4)

Suppliers of PD153035 (Hydrochloride)

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD65/10mg (In stock) USD248/50mg (In stock) USD420/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD50/5mg (In stock) USD65/10mg (In stock) USD248/50mg (In stock) USD420/100mg (In stock)
Quality Control & MSDS Files: MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD90/10mg (In stock) USD370/50mg (In stock) USD970/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD59/10mg (In stock) USD248/50mg (In stock) USD388/100mg (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD75/10mg () USD133/25mg () USD213/50mg ()

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Background Information of PD153035 (Hydrochloride)

PD153035 Hcl (ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src. IC50 value: 5.2/29 pM(Ki/IC50) [1] Target: EGFR in vitro: PD 153035 shows a potent and selective inhibitory effect on tyrosine phosphorylation induced with EGF with IC50 of 15 nM and 14 nM in Swiss 3T3 fibroblast and A-431 human epidermoid carcinoma cells, respectively [1].

Solubility of PD153035 (Hydrochloride)

Solubility Sources
DMSO <1.2mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 0.5 mg/mL (1.26 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL Selleck Chemicals LLC

Storage Condition of PD153035 (Hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PD153035 (Hydrochloride) - Not Found
PD153035 (Hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
396.67 C16H15BrClN3O2 183322-45-4 N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Structure Information of PD153035 (Hydrochloride)

Smiles COC1=CC2=NC=NC(NC3=CC=CC(Br)=C3)=C2C=C1OC.[H]Cl
InChI InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

Related Products

Other Form Products of PD153035 (Hydrochloride)

Name CAS Formula Suppliers
PD153035 153436-54-5 C16H14BrN3O2 6

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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