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KU-55933

(CAS: 587871-26-9)

Suppliers of KU-55933

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD84/10mg () USD264/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chemdea [email protected] (201) 690-4091 USA

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Exclusive Chemistry Ltd. [email protected] +7 499 346-68-31 Russia

Fax: +7 (484) 396-4302Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: Brand:

Price and Availability: USD52/5mg (In stock) USD69/10mg (In stock) USD145/25mg (In stock) USD221/50mg (In stock) USD392/100mg (In stock) USD645/200mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD66/5mg () USD84/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Quality Control & MSDS Files: CoA HNMR HPLC LCMS MSDS

ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD66/5mg () USD84/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .983 Brand: TargetMol

Price and Availability: USD65/5mg () USD115/10mg () USD205/25mg () USD325/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of KU-55933

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively; highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. IC50 Value: 13 nM Target: ATM in vitro: KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively.

Solubility of KU-55933

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 25 mg/mL with warming; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 μM; buffers, serum, or other additives may increase or decrease the aque. LC Laboratoies
DMSO ≥48mg/mL Water <1.2mg/mL Ethanol ≥11mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
Soluble to 100 mM in DMSO and to 50 mM in ethanol Tocris Bioscience Inc.

Storage Condition of KU-55933

Storage Condition Sources
Desiccate at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.
Desiccate at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [LCMS] MedKoo Biosciences, Inc.

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR Cell Cycle/DNA Damage Autophagy
Target Autophagy ATM/ATR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
KU-55933 - Discovery
KU-55933 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
395.49 C21H17NO3S2 587871-26-9 KU 55933;KU55933; 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

Structure Information of KU-55933

Smiles O=C1C=C(OC(C2=C3SC4=C(SC3=CC=C2)C=CC=C4)=C1)N5CCOCC5
InChI InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,33 mg/mL(83.44 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO and 47.5% PEG300For best results, use promptly afte
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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