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Linsitinib

(CAS: 867160-71-2)

Suppliers of Linsitinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD9/1mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD48/5mg (IN STOCK) USD57/10mg (IN STOCK) USD113/25mg (IN STOCK) USD157/50mg (IN STOCK) USD234/100mg (IN STOCK) USD377/200mg (IN STOCK) USD492/300mg (IN STOCK) USD740/500mg (IN STOCK)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/5mg (In stock) USD190/10mM/1mLIn DMSO (In stock) USD270/10mg (In stock) USD720/50mg (In stock) USD1670/200mg (In stock)
Quality Control & MSDS Files: HPLC HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Shanghai XingMo Biotechnology Co., Ltd. [email protected] 13524779951 CHINA

Fax: Purity: > 98% Brand: X-MoBio

Price and Availability: USD1200/1g (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD75/2mg () USD125/5mg () USD198/10mg () USD298/25mg () USD486/50mg ()

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Background Information of Linsitinib

Linsitinib(OSI-906) is highly potent, orally efficacious and highly selective, dual ATP-competitive inhibitor of IGF-1R (IC50= 35 nM) and insulin receptor (IC50=75 nM). IC50 value: 35 nM (IGF-1R); 75 nM (InsR) [1] Target: IGF-1R;InsR in vitro: OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM.

Solubility of Linsitinib

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 50 mg/mL; soluble in ethanol at 3 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 2-5 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO ≥81mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 84 mg/mL (199.29 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC

Storage Condition of Linsitinib

Storage Condition Sources
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Linsitinib Astellas Pharma Inc Adrenal cortical carcinoma 2009/9/30 2012/10/31 Phase 3 Clinical
Linsitinib Sarcoma Alliance for Research through Collaboration Gastrointestinal stromal tumor 2012/3/31 2014/3/01 Phase 2 Clinical
Linsitinib National Cancer Institute Small-cell lung cancer 2012/2/29 Phase 2 Clinical
Linsitinib National Cancer Institute Hormone refractory prostate cancer 2012/2/29 Phase 2 Clinical
Linsitinib MD Anderson Cancer Center Head and neck tumor 2013/6/30 2016/6/01 Phase 2 Clinical
Linsitinib - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
421.49 C26H23N5O 867160-71-2 OSI 906; OSI-906; OSI906; (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

Structure Information of Linsitinib

Smiles O[[email protected]@]1(C)C[[email protected]@H](C2=NC(C3=CC=C4C=CC(C5=CC=CC=C5)=NC4=C3)=C6C(N)=NC=CN62)C1
InChI InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+

Related Products

Other Form Products of Linsitinib

Name CAS Formula Suppliers
GSK 525762A 1260907-17-2 C22H22ClN5O2 5
PSEUDOISOCYTIDINE 57100-18-2 C9H13N3O5 2
5-BDBD 768404-03-1 C17H11BrN2O2 2
2-thienylacetyl-Trp1-Phe(4-F)2-Arg3-Pro4-Arg5-Asn6-NH2 1648905-42-3 C47H62FN15O8S 1
DS-1040 (Tosylate) 1335138-89-0 C23H35N3O5S 3
Keratan Sulfate 9056-36-4 N/A 2
Heparan Sulfate 9050-30-0 C12H19NO20S3 (monomer) 3

Recommended Products in Same Target

Name CAS Formula Suppliers
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BMS-536924 468740-43-4 C25H26ClN5O3 9
GSK1904529A 1089283-49-7 C44H47F2N9O5S 12
AZ7550 hydrochloride C27H32ClN7O2 0
IGF-1R inhibitor 1 C27H29ClN8O2 0
IGF-1R inhibitor 3 1421373-42-3 C26H27ClN8O2 0
IGF-1R inhibitor 4 1421373-67-2 C29H32N8O2 0
IGF-1R inhibitor 5 1421373-63-8 C28H32ClN7O2 0
IGF-1R inhibitor 6 1421373-56-9 C29H35N7O2 0

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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