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Silodosin

(CAS: 160970-54-7)

Suppliers of Silodosin

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

Beijing Hony Biopharma Technology Co., Ltd. [email protected] +86 (10) 6125-2983 / 6125-2985 / +86 13611224507 China

Fax: +86 (10) 6125-2196Purity: Brand:

Beijing Lang Rebone Technology Co., Ltd. [email protected] +86 (10) 5979-9429 / +86 18612220856 China

Fax: +86 (10) 8895-6459Purity: Brand:

Beijing Mesochem Technology Co., Ltd. [email protected],[email protected] +86 (10) 6540-5760 / 6737-4028 / +86 13366977697 China

Fax: +86 (10) 6571-2882Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/10mg () USD108/50mg ()

Chengdu Entry Scientific and Technological Development Co., Ltd [email protected] 86-28-85480141 85480145 CHINA

Fax: 86-28-85480147Purity: Brand:

Haimen HaoYuan Pharmaceutical Technology Co., Ltd. [email protected],[email protected] +86 (513) 6890-6390 / +86 15051292525 China

Fax: +86 (513) 6890-6239Purity: Brand:

Hangzhou Holypharm Biotech Co., Ltd. [email protected],[email protected] +86 (571) 8717-6852 / +86 18205813359 China

Fax: +86 (571) 8735-7695Purity: Brand:

Hangzhou Ledun Technology Co., Ltd. [email protected] +86 18667132977 China

Fax: Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/10mg () USD108/50mg ()
Quality Control & MSDS Files: HNMR NP-HPLC MSDS

Reco Tech Limited [email protected] +86 (10) 6060-5164 China

Fax: +86 (10) 6060-5164Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/5mg (In stock) USD320/10mg (In stock) USD340/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/10mg () USD108/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .985 Brand: TargetMol

Price and Availability: USD20/2mg () USD63/10mg () USD98/25mg ()

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Background Information of Silodosin

Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high uroselectivity; In treatment of dysuria. IC50 Value: Target: Adrenergic Receptor in vitro: Silodosin potently inhibited 2-[2-(4-hydroxy-3-[125I]iodophenyl)ethylaminomethyl]-alpha-tetralone binding to the cloned human alpha 1a-AR, with a Ki value of 0.036 nM, but had 583- and 56-fold lower potency at the alpha 1b- and alpha 1d-ARs, respectively.

Solubility of Silodosin

Solubility Sources
DMSO 100 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 99 mg/mL (199.78 mM); Ethanol99 mg/mL (199.78 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Silodosin

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Adrenergic Receptor
Research Area Endocrinology
Indications Prostate hyperplasia Urolithiasis Dysuria

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Silodosin Recordati SpA Prostate hyperplasia 2011/5/31 2013/8/31 Phase 4 Clinical
Silodosin JW Pharmaceutical Corp Urolithiasis 2011/10/31 2012/8/31 Phase 4 Clinical
Silodosin JW Pharmaceutical Corp Prostate hyperplasia 2010/10/31 2011/10/01 Phase 4 Clinical
Silodosin JW Pharmaceutical Corp Prostate hyperplasia 2010/12/31 2011/9/30 Phase 4 Clinical
Silodosin JW Pharmaceutical Corp Dysuria 2011/4/30 2012/1/31 Phase 4 Clinical
Silodosin - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
495.53 C25H32F3N3O4 160970-54-7 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-dihydro-1H-indole-7-carboxamide; KAD 3213; KMD 3213; Urief; (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide

Structure Information of Silodosin

Smiles NC(C1=C(N(CCCO)CC2)C2=CC(C[[email protected]@H](C)NCCOC3=C(OCC(F)(F)F)C=CC=C3)=C1)=O
InChI InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

Related Products

Other Form Products of Silodosin

Name CAS Formula Suppliers
(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide 160970-64-9 C25H32F3N3O4 11
PSB-12054 1407632-07-8 C20H19N5Na2O6 2
(+/-)-THREO-3-METHYLGLUTAMIC ACID 63088-04-0 C6H11NO4 3
RMI-61140 24140-98-5 C23H23ClN2O5 3
MSOP 66515-29-5 C4H10NO6P 2
(2R,3S)-Chlorpheg 140924-23-8 C11H12ClNO4 3
DIPPA (hydrochloride) 155512-52-0 C22H24Cl3N3OS 3
8 Hydroxy PIPAT (oxalate) 1451210-48-2 C18H24INO5 3
Cysteamine (bitartrate) 27761-19-9 C6H13NO6S 3
SB-203186 (hydrochloride) 207572-69-8 C16H21ClN2O2 1
N-MPPP (hydrochloride) 207452-97-9 C21H27ClN2O 2

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Recommended Products in the Same Indication

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Dutasteride 164656-23-9 C27H30F6N2O2 26

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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