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Flavopiridol (Hydrochloride)

(CAS: 131740-09-5)

Suppliers of Flavopiridol (Hydrochloride)

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD298/100mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: > 99% Brand:

Price and Availability: USD47/5mg (In stock) USD83/10mg (In stock) USD135/25mg (In stock) USD194/50mg (In stock) USD362/100mg (In stock) USD645/200mg (In stock) USD980/500mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: LCMS LCMS HNMR HNMR HNMR HNMR LCMS LCMS LCMS HNMR MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD100/10mM/1mLIn DMSO (In stock) USD110/10mg (In stock) USD220/25mg (In stock) USD380/50mg (In stock) USD680/100mg (In stock) USD1180/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .9931 Brand: TargetMol

Price and Availability: USD39/2mg () USD60/5mg () USD108/10mg () USD194/25mg () USD345/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #98 % Brand: Tocris

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Background Information of Flavopiridol (Hydrochloride)

Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM.

Solubility of Flavopiridol (Hydrochloride)

Solubility Sources
DMSO ≥85mg/mL Water ≥85mg/mL Ethanol ≥9.3mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 88 mg/mL (200.77 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL Selleck Chemicals LLC
Soluble to 100 mM in water and to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Flavopiridol (Hydrochloride)

Storage Condition Sources
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Autophagy
Target CDK Autophagy
Research Area Cancer
Indications Acute myelogenous leukemia Ovary tumor Testis tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Flavopiridol (Hydrochloride) Sidney Kimmel Comprehensive Cancer Center Acute myelogenous leukemia 2011/5/31 2013/7/31 Phase 2 Clinical
Flavopiridol (Hydrochloride) Sidney Kimmel Comprehensive Cancer Center Acute myelogenous leukemia 2011/4/30 Phase 2 Clinical
Flavopiridol (Hydrochloride) Ovary tumor 2013/5/31 2013/9/30 Phase 2 Clinical
Flavopiridol (Hydrochloride) Testis tumor 2013/5/31 2013/9/30 Phase 2 Clinical
Flavopiridol (Hydrochloride) Eastern Cooperative Oncology Group Acute myelogenous leukemia 2008/10/31 Phase 2 Clinical
Flavopiridol (Hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
438.3 C21H21Cl2NO5 131740-09-5 (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride; 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride

Structure Information of Flavopiridol (Hydrochloride)

Smiles O=C1C2=C(C([[email protected]]3[[email protected]@H](O)CN(C)CC3)=C(O)C=C2O)OC(C(C=CC=C4)=C4Cl)=C1.Cl
InChI InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m1./s1

Related Products

Other Form Products of Flavopiridol (Hydrochloride)

Name CAS Formula Suppliers
2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one C21H20ClNO5 9
2,4-Dibromo-5-nitropyridine 4487-57-4 C5H2Br2N2O2 9
2-Pyridinamine, 3-chloro-N-[3-chloro-2,4-dinitro-6-(trifluoromethyl)phenyl]-5-(trifluoromethyl)- 169327-87-1 C13H4Cl2F6N4O4 1
7-Hydroxyemodin 10228-40-7 C15H10O6 1
Quetiapine N-oxide 1076199-40-0 C21H25N3O3S 2
Fluorenylidenemethane 4425-82-5 C14H10 2
3-Bromo-5-chloropyrazolo[1,5-a]pyrimidine 960613-96-1 C6H3BrClN3 7
4-[(3-Chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol 847949-49-9 C21H22ClFN4O3 5
Benzonitrile, 4-bromo-2-(1,1-dimethylethoxy)- 246219-39-6 C11H12BrNO 1
Dimethylammonium formylmethylide 52334-92-6 C4H9NO 1
2-(3-Bromophenoxy)ethan-1-amine 926211-83-8 C8H10BrNO 6

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Senexin A 1366002-50-7 C17H14N4 8
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Fenretinide 65646-68-6 C26H33NO2 23
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LY2228820 862507-23-1 C26H37FN6O6S2 16
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 8
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Posaconazole 171228-49-2 C37H42F2N8O4 25
Decitabine 2353-33-5 C8H12N4O4 31

Safety Data of Flavopiridol (Hydrochloride)

Hazard Symbols:Xn Risk Statements:R22 Safety Statements:
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:light?yellow?to khaki solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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