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Enzalutamide

(CAS: 915087-33-1)

Suppliers of Enzalutamide

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Astatech, Inc. [email protected] +1 (215) 785-3197 USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing Lang Rebone Technology Co., Ltd. [email protected] +86 (10) 5979-9429 / +86 18612220856 China

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: LCMS NP-HPLC HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Quality Control & MSDS Files: CoA HNMR CNMR HPLC LCMS MSDS

ProbeChem [email protected] 86-21-80183644

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

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Price and Availability: USD26/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD150/5mg (In stock) USD270/10mg (In stock) USD300/10mM/1mLIn DMSO (In stock) USD770/50mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HPLC HPLC

Shanghai Book Chemical Co., Ltd. [email protected] +86 (21) 5137-0658 / +86 15802146997 / +86 15001988657 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Taizhou Crene Biotechnology Co., Ltd. [email protected] +86 (576) 8881-3233 / 8820-5808 / +86 13396860566 China

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Taizhou Taifeng Chemical Co., Ltd. [email protected] +86 (576) 8885-0501 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD59/2mg () USD105/5mg () USD185/10mg () USD330/25mg () USD585/50mg ()

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Background Information of Enzalutamide

Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM. IC50 value: 36 nM [1] Target: androgen-receptor in vitro: Enzalutamide has greater affinity to AR than Bicalutamide does in a competition assay with 16β-[18F]fluoro-5α-DHT (18-FDHT) in castration-resistant LNCaP/AR cells (AR-overexpressing).

Solubility of Enzalutamide

Solubility Sources
DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥15mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 92 mg/mL warming (198.08 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 2% DMSO+30% PEG3005 mg/mL Selleck Chemicals LLC

Storage Condition of Enzalutamide

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.
[CoA] [HNMR] [CNMR] [HPLC] [LCMS] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Autophagy Others
Target Androgen Receptor Autophagy
Research Area Cancer
Indications Hormone refractory prostate cancer Metastatic prostate cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Enzalutamide Astellas Pharma Global Development Inc Hormone refractory prostate cancer 2013/9/30 2018/6/30 Phase 4 Clinical
Enzalutamide Alliance for Clinical Trials in Oncology Hormone refractory prostate cancer 2013/12/31 2019/12/01 Phase 3 Clinical
Enzalutamide Medivation Inc; Novotech Clinical Research (M) Sdn. Bhd Hormone refractory prostate cancer 2010/9/30 Phase 3 Clinical
Enzalutamide Medivation Inc Hormone refractory prostate cancer 2009/9/30 2012/11/30 Phase 3 Clinical
Enzalutamide Dendreon Corp Metastatic prostate cancer 2013/9/30 Phase 2 Clinical
Enzalutamide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
464.44 C21H16F4N4O2S 915087-33-1 MDV3100;MDV-3100; MDV 3100; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Structure Information of Enzalutamide

Smiles S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3
InChI InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)

Related Products

Other Form Products of Enzalutamide

Name CAS Formula Suppliers
N-desmethyl Enzalutamide 1242137-16-1 C20H14F4N4O2S 7
Benzoic acid, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro- 1242137-15-0 C20H13F4N3O3S 2
Enzalutamide (D3) 1443331-82-5 C21H13D3F4N4O2S 2

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,92 mg/mLwarmed(198.08 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+1% CMC Na+1% Tween-80For best results, use p
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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