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Plerixafor (octahydrochloride)

(CAS: 155148-31-5)

Suppliers of Plerixafor (octahydrochloride)

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD76/10mg () USD199/50mg ()

China Jintai Biocompound Company [email protected] +86 (755) 8526-9922 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD76/10mg () USD199/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Taizhou Crene Biotechnology Co., Ltd. [email protected] +86 (576) 8881-3233 / 8820-5808 / +86 13396860566 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of Plerixafor (octahydrochloride)

Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. IC50 value: 44 nM (CXCR4); 5.7 nM (CXCL12-mediated chemotaxis) Target: CXCR4 in vitro: Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4.

Solubility of Plerixafor (octahydrochloride)

Solubility Sources
DMSO <1 mg/mL Water 100 mg/mL Ethanol <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro Water 100 mg/mL (125.87 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo Saline30 mg/mL Selleck Chemicals LLC
Soluble to 100 mM in water Tocris Bioscience Inc.

Storage Condition of Plerixafor (octahydrochloride)

Storage Condition Sources
Desiccate at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target CXCR
Research Area Inflammation/Immunology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Plerixafor (octahydrochloride) - No Development Reported
Plerixafor (octahydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
794.47 C28H62Cl8N8 155148-31-5 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]; AMD 3100; 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride

Structure Information of Plerixafor (octahydrochloride)

InChI InChI=1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H

Related Products

Other Form Products of Plerixafor (octahydrochloride)

Name CAS Formula Suppliers
Plerixafor 110078-46-1 C28H54N8 19

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Water,100 mg/mL(125.87 mM);In vitro:DMSO,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):SalineFor best results, use promptly after mixing.,30 mg/
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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