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Sitaxsentan (sodium)

(CAS: 210421-74-2)

Suppliers of Sitaxsentan (sodium)

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD15/1mg ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD240/10mg () USD816/50mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD240/10mg () USD816/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

Melone Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (411) 8259-3920 China

Fax: +86 (411) 8259-3613Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD210/5mg (In stock) USD270/10mg (In stock) USD400/10mM/1mLIn DMSO (In stock) USD970/50mg (In stock) USD1270/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai DND Pharm-Technology Co., Inc. [email protected],[email protected] +86 (21) 5878-3620 / 5878-3570 ex 8011 China

Fax: +86 (21) 5878-3595 ex 8003Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD240/10mg () USD816/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD152/10mg () USD488/100mg ()

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Background Information of Sitaxsentan (sodium)

Sitaxsentan sodium (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist.

Solubility of Sitaxsentan (sodium)

Solubility Sources
DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 40 mg/mL (83.87 mM); Ethanol20 mg/mL (41.93 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Sitaxsentan (sodium)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Endothelin Receptor
Research Area Cardiovascular Disease
Indications Pulmonary hypertension Pulmonary artery hypertension

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Sitaxsentan (sodium) - Withdrawn
Sitaxsentan (sodium) Pfizer Inc Pulmonary hypertension 2009/12/31 2011/3/31 Phase 4 Clinical
Sitaxsentan (sodium) Pfizer Japan Inc Pulmonary artery hypertension 2010/11/30 2010/12/01 Phase 3 Clinical
Sitaxsentan (sodium) Pfizer Inc Pulmonary artery hypertension 2010/8/31 2010/11/01 Phase 3 Clinical
Sitaxsentan (sodium) Pfizer Inc Pulmonary hypertension 2003/3/31 2011/7/01 Phase 3 Clinical
Sitaxsentan (sodium) Pfizer Inc Pulmonary hypertension 2009/5/31 2011/4/01 Phase 3 Clinical
Sitaxsentan (sodium) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
476.89 C18H14ClN2NaO6S2 210421-74-2 THELIN ; TBC11251 sodium salt; TBC11251; sodium (4-chloro-3-methylisoxazol-5-yl)((2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophen-3-yl)sulfonyl)amide

Structure Information of Sitaxsentan (sodium)

Smiles O=S([N-]C1=C(C(C)=NO1)Cl)(C2=C(SC=C2)C(CC3=C(C=C4OCOC4=C3)C)=O)=O.[Na+]
InChI InChI=1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1

Related Products

Other Form Products of Sitaxsentan (sodium)

Name CAS Formula Suppliers
Sitaxsentan (phosphate) 215501-46-5 C18H17ClN2O10PS2- 1
sitaxsentan 184036-34-8 C18H15ClN2O6S2 4

Recommended Products in Same Target

Name CAS Formula Suppliers
ACT-132577 1103522-45-7 C16H14Br2N6O4S 5
BQ-788 (sodium salt) 156161-89-6 C34H50N5NaO7 10
Sulfisoxazole 127-69-5 C11H13N3O3S 10
Atrasentan (hydrochloride) 195733-43-8 C29H39ClN2O6 7
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 15
SPI-1620 142569-99-1 C83H112N19O25 7
Atrasentan 173937-91-2 C29H38N2O6 9
Sitaxsentan (phosphate) 215501-46-5 C18H17ClN2O10PS2- 1
Macitentan 441798-33-0 C19H20Br2N6O4S 9
Avosentan 290815-26-8 C23H21N5O5S 4
Zibotentan 186497-07-4 C19H16N6O4S 8
Ambrisentan 177036-94-1 C22H22N2O4 11
sitaxsentan 184036-34-8 C18H15ClN2O6S2 4
Bosentan 147536-97-8 C27H29N5O6S 12
Endothelin 1 117399-94-7 C109H159N25O32S5 7
BQ-123 136553-81-6 C31H42N6O7 11
Aminaftone 14748-94-8 C18H15NO4 4
Ro 46-2005 150725-87-4 C23H27N3O6S 5
ZD-1611 186497-38-1 C22H24N4O5S 3
Macitentan (n-butyl analogue) 556797-16-1 C20H21Br2N5O4S 4

Recommended Products in the Same Indication

Name CAS Formula Suppliers
sitaxsentan 184036-34-8 C18H15ClN2O6S2 4
Tadalafil 171596-29-5 C22H19N3O4 20
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 16
Milrinone 78415-72-2 C12H9N3O 17
Macitentan 441798-33-0 C19H20Br2N6O4S 9
Riociguat 625115-55-1 C20H19FN8O2 8
Sildenafil 139755-83-2 C22H30N6O4S 13
Bosentan 147536-97-8 C27H29N5O6S 12
Ambrisentan 177036-94-1 C22H22N2O4 11
Clevidipine 167221-71-8 C21H23Cl2NO6 13
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 15

Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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