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Calcipotriol

(CAS: 112965-21-6)

Suppliers of Calcipotriol

Company Name Email Tel Country
Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >98% Brand:

Price and Availability: USD1295/100mg (In stock)
Quality Control & MSDS Files: CoA MSDS

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Hydragon Pharma Co., Ltd. [email protected] +86 (21) 5021-5258 / 5021-8972 China

Fax: +86 (21) 5021-5756Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: NP-HPLC NP-HPLC NP-HPLC HNMR HNMR HNMR HNMR HNMR NP-HPLC NP-HPLC NP-HPLC NP-HPLC NP-HPLC HNMR HNMR NP-HPLC NP-HPLC NP-HPLC NP-HPLC NP-HPLC MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 90% Brand:

Price and Availability: USD103/5mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Tianjin Weijie Technology Co., Ltd. [email protected] +86 (22) 8789-3923 / 8789-4931 China

Fax: +86 (22) 8789-2482Purity: Brand:

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #98 % Brand: Tocris

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Calcipotriol

Calcipotriol, a 1,25-Dihydroxyvitamin D3 analogue, is used as topical treatment for psoriasis. IC50 value: Target: Vitamin D3 analogue in vitro: Calcipotriol increased hCAP18 mRNA expression in IL-17/IL-22-stimulated keratinocytes.

Solubility of Calcipotriol

Solubility Sources
Soluble to 100 mM in DMSO and to 100 mM in ethanol MedChemexpress Co., Ltd.
Soluble to 100 mM in DMSO and to 100 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Calcipotriol

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Desiccate at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[NP-HPLC] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Others
Target VD/VDR
Research Area Inflammation/Immunology
Indications Psoriasis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Calcipotriol University of Pittsburgh Psoriasis 2013/1/31 2014/1/31 Phase 4 Clinical
Calcipotriol Derm Research, PLLC Psoriasis 2013/1/31 2014/1/01 Phase 4 Clinical
Calcipotriol University of California San Francisco Psoriasis 2009/6/30 2009/12/31 Phase 4 Clinical
Calcipotriol Hoffmann-La Roche Inc Psoriasis 2007/2/28 2009/8/31 Phase 4 Clinical
Calcipotriol LEO Pharma A/S Psoriasis 2005/10/31 2006/2/28 Phase 4 Clinical
Calcipotriol - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
412.6 C27H40O3 112965-21-6 (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol; (1S,3S,E)-5-((E)-2-((1R,3aR,7aR)-1-((2S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

Structure Information of Calcipotriol

Smiles O[[email protected]@H]1C[[email protected]](O)C(/C(C1)=C/C=C2[[email protected]@]3([H])CC[[email protected]]([[email protected]](/C=C/C(C4CC4)O)C)[[email protected]@]3(C)CCC/2)=C
InChI InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10+/t17-,22-,23+,24+,25?,26-,27+/m0/s1

Related Products

Other Form Products of Calcipotriol

Name CAS Formula Suppliers
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 7
Rogaratinib 1443530-05-9 C23H26N6O3S 3
BAY1125976 1402608-02-9 C23H21N5O 3
BAY-876 1799753-84-6 C24H16F4N6O2 3
AZD0156 1821428-35-6 C26H31N5O3 5
Mivebresib 1445993-26-9 C22H19F2N3O4S 5
KDM5A-IN-1 1905481-36-8 C15H22N4O2 4
CBR-5884 681159-27-3 C14H12N2O4S2 4
SR-3029 1454585-06-8 C23H19F3N8O 4
Sulfathiourea 515-49-1 C7H9N3O2S2 2
(1S,2S)-2-PCCA 1609624-97-6 C30H37N3O 1
(1R,2R)-2-PCCA 1287205-42-8 C30H37N3O 1

Recommended Products in Same Target

Name CAS Formula Suppliers
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 5
(24R)-MC 976 112828-09-8 C27H42O3 6
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 6
Calcitriol Impurities D 103656-40-2 C28H46O3 4
Calcifediol (monohydrate) 63283-36-3 C27H44O2 10
Cholecalciferol 67-97-0 C27H44O 15
(24S)-MC 976 112849-14-6 C27H42O3 7
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 5
VD3-D6 118584-54-6 C27H38D6O 5
VD2-D3 1217448-46-8 C28H41D3O 8
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 9
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 8
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 7
Cholecalciferol 67-97-0 C27H44O 7
Calcitriol Impurities A 73837-24-8 C27H44O3 5
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 4
Paricalcitol 131918-61-1 C27H44O3 14
MC 976 129831-99-8 C27H42O3 5
24R-Calcipotriol 112827-99-3 C27H40O3 6
MC 1046 126860-83-1 C27H38O3 6

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Dimethyl fumarate 624-49-7 C6H8O4 17
VX-765 273404-37-8 C24H33ClN4O6 15
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(3R,4S)-Tofacitinib 1092578-46-5 C16H20N6O 6
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(3S,4R)-Tofacitinib 1092578-48-7 C16H20N6O 6
BMS-582949 (hydrochloride) 912806-16-7 C22H27ClN6O2 5
Seletalisib 1362850-20-1 C23H14ClF3N6O 4
GSK2982772 1622848-92-3 C20H19N5O3 3
Desoximetasone 382-67-2 C22H29FO4 9

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:166-168°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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