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BMS-599626

(CAS: 714971-09-2)

Suppliers of BMS-599626

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD27/1mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD150/10mg (Get quote) USD450/50mg (Get quote)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD150/10mg (Get quote) USD450/50mg (Get quote)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/5mg (In stock) USD390/10mM/1mLIn DMSO (In stock) USD570/25mg (In stock) USD1270/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD150/10mg (Get quote) USD450/50mg (Get quote)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .988 Brand: TargetMol

Price and Availability: USD49/1mg () USD123/5mg () USD174/10mg () USD298/25mg () USD539/50mg ()

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Background Information of BMS-599626

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. IC50 value: 20 nM (HER1); 30 nM (HER2) [1] Target: HER1/HER2 in vitro: BMS-599626 inhibited HER1 and HER2 with IC50 of 20 and 30 nmol/L, respectively, and was highly selective when tested against a broad panel of diverse protein kinases.

Solubility of BMS-599626

Solubility Sources
DMSO 113 mg/ml; Water <1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 113 mg/mL (212.98 mM); Ethanol20 mg/mL (37.69 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC

Storage Condition of BMS-599626

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications Advanced solid tumor Glioma Solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
BMS-599626 Bristol-Myers Squibb Co Advanced solid tumor 2004/3/31 2006/5/01 Phase 1 Clinical
BMS-599626 Duke University Glioma 2009/11/30 2013/3/31 Phase 1 Clinical
BMS-599626 Bristol-Myers Squibb Co Advanced solid tumor 2004/5/31 Phase 1 Clinical
BMS-599626 Jonsson Comprehensive Cancer Center Solid tumor 2004/8/31 Phase 1 Clinical
BMS-599626 - Discontinued
BMS-599626 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
530.55 C27H27FN8O3 714971-09-2 BMS599626;AC480;BMS 599626;AC-480;AC 480; (S)-morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate

Structure Information of BMS-599626

Smiles O=C(NC1=CN2C(C(NC3=CC4=C(N(CC5=CC=CC(F)=C5)N=C4)C=C3)=NC=N2)=C1C)OC[[email protected]]6NCCOC6
InChI InChI=1S/C27H27FN8O3/c1-17-23(34-27(37)39-15-22-14-38-8-7-29-22)13-36-25(17)26(30-16-32-36)33-21-5-6-24-19(10-21)11-31-35(24)12-18-3-2-4-20(28)9-18/h2-6,9-11,13,16,22,29H,7-8,12,14-15H2,1H3,(H,34,37)(H,30,32,33)/t22-/m0/s1

Related Products

Other Form Products of BMS-599626

Name CAS Formula Suppliers
BMS-599626 (Hydrochloride) 873837-23-1 C27H28ClFN8O3 4

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Chemical and Physical Properties

Appearance: Melting point:
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