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TAK-700

(CAS: 426219-18-3)

Suppliers of TAK-700

Company Name Email Tel Country
Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD147/5mg (In stock) USD330/10mM/1mLIn DMSO (In stock) USD997/50mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD110/5mg (Get quote) USD165/10mg (Get quote) USD715/50mg (Get quote)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD71/2mg () USD96/5mg () USD168/10mg () USD318/25mg () USD568/50mg ()

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Background Information of TAK-700

TAK-700 is an oral, selective, non-steroidal androgen synthesis inhibitor of the 17,20 lyase, which is a key enzyme in the production of steroidal hormones. IC50 value: Target: 17,20 lyase In preclinical studies, TAK-700 has been shown to bind to and inhibit the enzyme 17,20 lygase in both the testes and adrenal glands.

Solubility of TAK-700

Solubility Sources
(25°C) * In vitro DMSO 61 mg/mL (198.47 mM); Ethanol8 mg/mL (26.02 mM); Water<1 mg/mL (<1 mM); In vivo 0.5% methylcellulose30 mg/mL Selleck Chemicals LLC

Storage Condition of TAK-700

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HPLC] [HNMR] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TAK-700 SWOG Metastatic prostate cancer 2013/3/31 2020/7/01 Phase 3 Clinical
TAK-700 Schweizerische Arbeitsgruppe fuer angewandte Krebsforschung; Swiss Group for Clinical Cancer Research Hormone refractory prostate cancer 2012/9/30 2020/12/31 Phase 3 Clinical
TAK-700 Radiation Therapy Oncology Group Hormone dependent prostate cancer 2012/5/31 2014/10/01 Phase 3 Clinical
TAK-700 Millennium Pharmaceuticals Inc; PPD Development (S) Pte Ltd; Takeda Bio Development Center Ltd Hormone refractory prostate cancer 2010/11/30 2013/7/31 Phase 3 Clinical
TAK-700 Millennium Pharmaceuticals Inc Hormone refractory prostate cancer 2010/10/31 2013/6/30 Phase 3 Clinical
TAK-700 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
307.35 C18H17N3O2 426219-18-3 TAK 700; TAK700; 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide

Structure Information of TAK-700

Smiles O=C(C1=CC=C2C=C(C3(O)CCN4C=NC=C43)C=CC2=C1)NC
InChI InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)

Related Products

Other Form Products of TAK-700

Name CAS Formula Suppliers
TAK-700 (R-form) 752243-39-3 C18H17N3O2 1
TAK-700 (salt) 426219-53-6 C28H28N4O7 1

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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