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Ambrisentan

(CAS: 177036-94-1)

Suppliers of Ambrisentan

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Beijing Hony Biopharma Technology Co., Ltd. [email protected] +86 (10) 6125-2983 / 6125-2985 / +86 13611224507 China

Fax: +86 (10) 6125-2196Purity: Brand:

Beijing Mesochem Technology Co., Ltd. [email protected],[email protected] +86 (10) 6540-5760 / 6737-4028 / +86 13366977697 China

Fax: +86 (10) 6571-2882Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/10mg (In stock) USD220/10mM/1mLIn DMSO (In stock) USD570/50mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD72/10mg ()

Shanghai Longschem Co., Ltd. [email protected] +86 (21) 3635-6756 China

Fax: +86 (21) 3656-6757Purity: Brand:

Shanghai Taiheng Industry Co., Ltd. [email protected] +86 (21) 6469-9426 China

Fax: +86 (21) 6469-9429Purity: Brand:

Shanghai Tingychem Co., Ltd. [email protected] +86 (21) 3393-8511 China

Fax: Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD48/5mg () USD82/10mg () USD133/25mg ()

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Background Information of Ambrisentan

Ambrisentan(BSF 208075; LU 208075) is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor.

Solubility of Ambrisentan

Solubility Sources
DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 76 mg/mL (200.83 mM); Ethanol22 mg/mL (58.13 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Ambrisentan

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Endothelin Receptor
Research Area Cardiovascular Disease
Indications Congenital heart defect Pulmonary hypertension Scleroderma Cardiac failure

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ambrisentan Washington University in St Louis Congenital heart defect 2012/8/31 2015/1/31 Phase 4 Clinical
Ambrisentan University of Alabama at Birmingham Pulmonary hypertension 2011/5/31 2013/7/31 Phase 4 Clinical
Ambrisentan University of California Los Angeles Pulmonary hypertension 2009/3/31 2010/12/31 Phase 4 Clinical
Ambrisentan University of California Los Angeles Scleroderma 2009/3/31 2010/12/31 Phase 4 Clinical
Ambrisentan University of Texas Southwestern Medical Center Cardiac failure 2009/1/31 2012/6/30 Phase 4 Clinical
Ambrisentan University of Texas Southwestern Medical Center Pulmonary hypertension 2009/1/31 2012/6/30 Phase 4 Clinical
Ambrisentan - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
378.42 C22H22N2O4 177036-94-1 2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid; 2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid

Structure Information of Ambrisentan

Smiles O=C(O)C(OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3
InChI InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)

Related Products

Other Form Products of Ambrisentan

Name CAS Formula Suppliers

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sitaxsentan 184036-34-8 C18H15ClN2O6S2 7
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Endothelin 1 117399-94-7 C109H159N25O32S5 8
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Macitentan (n-butyl analogue) 556797-16-1 C20H21Br2N5O4S 5

Recommended Products in the Same Indication

Name CAS Formula Suppliers
sitaxsentan 184036-34-8 C18H15ClN2O6S2 7
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Tadalafil 171596-29-5 C22H19N3O4 29
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 24
Cinaciguat 329773-35-5 C36H39NO5 8
Milrinone 78415-72-2 C12H9N3O 27
Istaroxime (hydrochloride) 374559-48-5 C21H33ClN2O3 11
Riociguat 625115-55-1 C20H19FN8O2 11
Sildenafil 139755-83-2 C22H30N6O4S 19
Tolvaptan 150683-30-0 C26H25ClN2O3 16
Istaroxime 203737-93-3 C21H32N2O3 8
Sitaxsentan (sodium) 210421-74-2 C18H14ClN2NaO6S2 16
Bosentan 147536-97-8 C27H29N5O6S 19
Clevidipine 167221-71-8 C21H23Cl2NO6 19
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 23
AHU-377 (hemicalcium salt) 1369773-39-6 C24H28NO5- 11

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:>150°C (dec.)
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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