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LY2157299

(CAS: 700874-72-2)

Suppliers of LY2157299

Company Name Email Tel Country
Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >97% Brand:

Price and Availability: USD3850/1g (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD80/5mg (In stock) USD110/10mg (In stock) USD350/50mg (In stock) USD550/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD80/5mg (In stock) USD110/10mg (In stock) USD350/50mg (In stock) USD550/100mg (In stock) USD850/200mg (In stock) USD1250/500mg (In stock)
Quality Control & MSDS Files: LCMS LCMS HNMR HNMR HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Quality Control & MSDS Files: CoA HNMR HPLC MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 90% Brand:

Price and Availability: USD33/10mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/5mg (In stock) USD270/10mg (In stock) USD272/10mM/1mLIn DMSO (In stock) USD770/50mg (In stock) USD2270/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD99/5mg (In stock) USD135/10mg (In stock) USD405/50mg (In stock) USD750/100mg (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .999 Brand: TargetMol

Price and Availability: USD133/10mg () USD341/50mg ()

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Background Information of LY2157299

LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. IC50 value: 56 nM [1] Target: TGFβ receptor I in vitro: LY2157299 potently inhibits the TGFβ receptor signaling.

Solubility of LY2157299

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
DMSO ≥72mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
DMSO 74 mg/mL (200 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol <1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of LY2157299

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications Glioma Advanced solid tumor Hepatocellular carcinoma

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LY2157299 Eli Lilly & Co Glioma 2011/4/30 2015/1/31 Phase 2 Clinical
LY2157299 Eli Lilly & Co 2013/10/31 2013/11/30 Phase 1 Clinical
LY2157299 Eli Lilly & Co 2013/1/31 2013/2/28 Phase 1 Clinical
LY2157299 Eli Lilly & Co Advanced solid tumor 2012/11/30 2014/4/30 Phase 1 Clinical
LY2157299 Eli Lilly & Co Hepatocellular carcinoma 2011/3/31 2015/5/31 Phase 2 Clinical
LY2157299 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
369.42 C22H19N5O 700874-72-2 LY-2157299;LY 2157299; 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide

Structure Information of LY2157299

Smiles CC1=CC=CC(C2=NN3C(CCC3)=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O)=N1
InChI InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.40 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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