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Riociguat

(CAS: 625115-55-1)

Suppliers of Riociguat

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD60/5mg (In stock) USD90/10mg (In stock) USD240/50mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD60/5mg (In stock) USD90/10mg (In stock) USD240/50mg (In stock) USD400/100mg (In stock) USD640/200mg (In stock)
Quality Control & MSDS Files: HNMR NP-HPLC LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Quality Control & MSDS Files: CoA HNMR HPLC MS MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 97% Brand:

Price and Availability: USD59/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand: Selleck

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD70/5mg (In stock) USD135/10mg (In stock) USD405/50mg (In stock)

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Background Information of Riociguat

Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase (sGC). IC50 value: Target: sGC stimulator Riociguat (BAY 63-2521; BAY 632521) is a novel drug that is currently in clinical development by Bayer.

Solubility of Riociguat

Solubility Sources
DMSO MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.

Storage Condition of Riociguat

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [MS] MedKoo Biosciences, Inc.

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Riociguat Bayer AG Chronic thromboembolic pulmonary hypertension 2013/2/04 Phase 3 Clinical
Riociguat Bayer AG Pulmonary hypertension 2009/7/31 2014/9/30 Phase 3 Clinical
Riociguat Bayer AG Pulmonary hypertension 2009/3/31 2014/9/30 Phase 3 Clinical
Riociguat Bayer AG Chronic thromboembolic pulmonary hypertension 2009/2/28 2012/6/30 Phase 3 Clinical
Riociguat Bayer AG Pulmonary artery hypertension 2008/12/31 2012/5/31 Phase 3 Clinical
Riociguat - Pre-registration
Riociguat - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
422.42 C20H19FN8O2 625115-55-1 BAY 63-2521; BAY 632521; methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate

Structure Information of Riociguat

Smiles FC1=CC=CC=C1CN2C3=NC=CC=C3C(C4=NC(N)=C(C(N)=N4)N(C)C(OC)=O)=N2
InChI InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.51 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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