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Palonosetron (Hydrochloride)

(CAS: 135729-62-3)

Suppliers of Palonosetron (Hydrochloride)

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD72/50mg () USD108/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chem-Cook Chemicals Ltd. [email protected] +86 (23) 6253-9363 / +86 13657620624 China

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Chengdu Sino-Strong Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (28) 8278-3659 China

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Chongqing Yifutech Co., Ltd. [email protected] +86 (23) 6842-1858 / +86 13983604463 / 13068320173 China

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Datang (Hangzhou) Pharmachem Co., Ltd. [email protected] +86 (571) 8731-1096 China

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Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

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Hangzhou Rongda Pharm & Chem Co., Ltd. [email protected] +86 (571) 2828-1880 / 2828-1885 China

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Heta Pharm & Chem Co., Ltd. [email protected],[email protected] +86 (571) 8829-8691 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD72/50mg () USD108/100mg ()

Nanjing Chalf-pharm Technology Co., Ltd. [email protected] +86 (25) 5701-8978 China

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD170/10mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD72/50mg () USD108/100mg ()

Shenzhen Axitec Co., Ltd [email protected] +86-755-26491310 CHINA

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Simcere Pharmaceutical Group [email protected] +86 (25) 8556-6666 ex 8851 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD80/5mg () USD133/10mg () USD256/50mg ()

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Background Information of Palonosetron (Hydrochloride)

Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). IC50 Value: Target: 5-HT Receptor Palonosetron is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy.

Solubility of Palonosetron (Hydrochloride)

Solubility Sources
(25°C) * In vitro Water 67 mg/mL (201.27 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Palonosetron (Hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target 5-HT Receptor
Research Area Cardiovascular Disease
Indications Chemotherapy-induced emesis Emesis Nausea

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Palonosetron (Hydrochloride) Shanghai Changzheng Hospital Chemotherapy-induced emesis 2011/7/31 2012/8/01 Phase 4 Clinical
Palonosetron (Hydrochloride) Spanish Breast Cancer Research Group Chemotherapy-induced emesis 2011/5/31 2013/6/30 Phase 4 Clinical
Palonosetron (Hydrochloride) PETHEMA Foundation Chemotherapy-induced emesis 2006/11/30 2009/9/30 Phase 4 Clinical
Palonosetron (Hydrochloride) Schering-Plough Corp Emesis 2007/4/30 2008/2/29 Phase 4 Clinical
Palonosetron (Hydrochloride) Schering-Plough Corp Nausea 2007/4/30 2008/2/29 Phase 4 Clinical
Palonosetron (Hydrochloride) Merck & Co Inc Chemotherapy-induced emesis 2006/10/31 2008/9/30 Phase 4 Clinical
Palonosetron (Hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
332.87 C19H25ClN2O 135729-62-3 (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride; (S)-2-((1R,3S,4R)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride

Structure Information of Palonosetron (Hydrochloride)

Smiles O=C(C1=C2C3=CC=C1)N(C[[email protected]@]2([H])CCC3)[[email protected]@H]4C[[email protected]]5CC[[email protected]]4([H])CC5.Cl
InChI InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1

Related Products

Other Form Products of Palonosetron (Hydrochloride)

Name CAS Formula Suppliers
Palonosetron 135729-61-2 C19H24N2O 7

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Granisetron (Hydrochloride) 107007-99-8 C18H25ClN4O 23
Granisetron 109889-09-0 C18H24N4O 12

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:>290°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Water,67 mg/mL(201.27 mM);In vitro:DMSO,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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